New combo therapy targets Hard-to-Treat rheumatoid arthritis

NCT ID NCT06301373

Recruiting now Disease control Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group for 12 weeks, then followed for 48 weeks. The main goal is to see if more people in the combo group achieve at least a 20% improvement in symptoms (ACR20).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: methotrexate and tofacitinib (a JAK inhibitor)
What this could lead to: If successful, this could show that combining methotrexate with tofacitinib early on works better than methotrexate alone for people with a specific type of rheumatoid arthritis, leading to better disease control.
What could go wrong: This is a small, early-stage study (130 people) with no placebo group, so results may not apply to everyone. Tofacitinib has known risks like infections and blood clots, and the 12-week treatment period is short.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

Foshan Hopsital of Traditional Chinese Medicine
RECRUITING

Foshan, Guangdong, 528000, China
Pu Ning Shi Ren Ming Yi Yuan
RECRUITING

Jieyang, Guangdong, 515300, China
Shenshan Medical Central, Memorial Hospital of Sun Yat-sen University
RECRUITING

Shantou, Guangdong, 516621, China
Sun Yat-sen Memorial Hospital
RECRUITING

Guangzhou, Guangdong, 510120, China
The Affiliated Panyu Central Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 511400, China

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