New combo therapy targets Hard-to-Treat rheumatoid arthritis
NCT ID NCT06301373
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group for 12 weeks, then followed for 48 weeks. The main goal is to see if more people in the combo group achieve at least a 20% improvement in symptoms (ACR20).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methotrexate and tofacitinib (a JAK inhibitor)
What this could lead to
If successful, this could show that combining methotrexate with tofacitinib early on works better than methotrexate alone for people with a specific type of rheumatoid arthritis, leading to better disease control.
What could go wrong
This is a small, early-stage study (130 people) with no placebo group, so results may not apply to everyone. Tofacitinib has known risks like infections and blood clots, and the 12-week treatment period is short.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Foshan Hopsital of Traditional Chinese Medicine
RECRUITINGFoshan, Guangdong, 528000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pu Ning Shi Ren Ming Yi Yuan
RECRUITINGJieyang, Guangdong, 515300, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shenshan Medical Central, Memorial Hospital of Sun Yat-sen University
RECRUITINGShantou, Guangdong, 516621, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen Memorial Hospital
RECRUITINGGuangzhou, Guangdong, 510120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Panyu Central Hospital of Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, 511400, China
Contact Phone: •••-•••-•••• Email: •••••@•••••