RHEUMATOID ARTHRITIS

This early-stage study is testing a new cell therapy called CC-97540 for people with severe autoimmune diseases that haven't responded to multiple treatments. The therapy involves collecting a patient's own immune cells, engineering them to target specific immune cells (B cells),…

This study is testing three different targeted treatment approaches for adults with moderate to severe rheumatoid arthritis who haven't responded well to previous biologic medications. Approximately 180 participants worldwide will receive either one of two experimental drugs alon…

This study is testing an experimental drug called Afimkibart for people with moderate to severe rheumatoid arthritis (RA) who haven't gotten enough relief from common advanced treatments. About 160 participants will receive either the new drug or a placebo to see if it safely red…

This early-stage study is testing a new type of cell therapy called anti-CD19/BCMA universal CAR-T cells in people with severe autoimmune diseases that have not improved with standard treatments. The main goals are to check if the treatment is safe and to see if it can help contr…

This early-stage study is testing the safety and side effects of a new drug called plamotamab in adults with moderate to severe rheumatoid arthritis. About 47 participants who haven't responded well to standard arthritis medications will receive injections of the drug at differen…

This is the first study in people to test a new drug called surovatamig for rheumatoid arthritis and lupus. The main goal is to check its safety and how the body processes it in 48 adults with these conditions. Researchers will give the drug as an injection under the skin at diff…

This study is testing if a personalized, two-drug treatment works better than the standard single drug for people with a severe type of rheumatoid arthritis (RA). Researchers will enroll 130 adults with this specific 'myeloid-stromal' type of RA. One group will receive the standa…

This study is testing whether taking vitamin E supplements for one month can help reduce inflammation and ease symptoms in people with rheumatoid arthritis. Researchers will compare vitamin E against a placebo pill in 46 female participants who have early-stage arthritis and low …

This study is testing whether a medication called baricitinib can help repair existing bone damage in people with active rheumatoid arthritis. Sixty adult patients with active arthritis and visible bone erosion will take either the real drug or a placebo pill daily for 24 weeks. …

This is the first study in humans to test the safety and side effects of a new drug called LY4298445. It will involve both healthy volunteers and people with systemic lupus erythematosus or rheumatoid arthritis. The main goal is to see how the body handles the drug and to find a …

This study is testing an investigational drug called LY3871801 for adults with moderate-to-severe rheumatoid arthritis (RA) who haven't gotten enough relief from standard treatments. About 380 participants will receive either the drug or a placebo to see if it safely reduces dise…

This study is testing whether combining two medications, telitacicept and baricitinib, can help people with rheumatoid arthritis that hasn't improved with other treatments. Researchers will enroll about 30 adults to see if this combination can reduce disease activity and is safe.…

This early-stage study aims to test the safety and side effects of a new drug called GS-0151 in adults with rheumatoid arthritis. Researchers will give different doses to 75 participants to see how their bodies handle the medication and monitor for any problems. The study will al…

This study is testing a new treatment approach for rheumatoid arthritis. It compares two strategies: one group starts with a common arthritis drug for 12 weeks, then switches to a different drug for 36 weeks. The other group stays on the first drug the whole time. The goal is to …

This study is testing an investigational drug called SPY002-072 to see if it can reduce disease activity in adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. It will compare the drug to a placebo in about 285 particip…

This is an early Phase 1 study to test the safety and side effects of a new investigational drug called MK-1045. It will involve a small group of 21 people with either systemic lupus erythematosus or rheumatoid arthritis. The main goal is to find safe dose levels by checking how …

This study is testing whether a new drug called BGB-45035 can help control moderate to severe rheumatoid arthritis in adults. It's for people whose current medications aren't working well enough. Researchers will compare the drug to a placebo (inactive treatment) to see if it red…

This early-stage study is testing a new drug called CND261 in people with rheumatoid arthritis. The main goal is to check if the drug is safe and how it behaves in the body. About 47 participants with moderate to severe arthritis will receive the drug and be monitored for side ef…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing if adding a family doctor to a team of arthritis specialists can help patients with rheumatoid arthritis manage their other health risks. People with this condition have a higher chance of heart problems, bone weakness, and infections. The research will see …

This study is testing whether an experimental drug called CIT-013 can reduce disease activity in adults with moderately active rheumatoid arthritis. 88 participants will receive either the drug or a placebo injection every other week for 6 weeks, with regular clinic checkups to m…

This small pilot study is testing whether a guided, at-home exercise program is practical and safe for people recently diagnosed with rheumatoid arthritis. The goal is to see if patients can stick to the workout plan and if it's well-received, to help design a larger future study…

This is an early-stage safety study testing a new type of personalized cell therapy called AZD0120. It aims to see if this treatment is safe and tolerable for adults with severe autoimmune diseases like systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid…

This study is checking how well a silicone finger joint implant works and how safe it is for people with arthritis. It will follow 86 adults who get the implant to see if their hand function improves and to monitor the implant's long-term performance. The goal is to provide bette…

This study is testing if a personalized approach to drug dosing works better than standard care for keeping rheumatoid arthritis under control. It will follow 350 adults already taking a common arthritis medication (adalimumab) for 18 months. Researchers will compare two methods:…

This study is testing whether a new support program helps people with rheumatoid arthritis stick to their prescribed medications. The program involves pharmacists and doctors working together, starting support during a hospital stay and continuing it after the patient goes home. …

This study is testing a new computer navigation system designed to help surgeons place the 'cup' part of a hip replacement more accurately. It compares the planned position of the implant before surgery to its actual position after surgery. The goal is to see if this technology l…

This study is testing different schedules to help people with rheumatoid arthritis safely reduce their steroid medication. Researchers want to understand why some people struggle when lowering their dose while others don't. They'll follow 200 participants to see which tapering ap…

This early-stage study is testing a new mRNA-based treatment called HN2301 in people with autoimmune diseases including lupus, scleroderma, and rheumatoid arthritis. The main goal is to check if the treatment is safe and well-tolerated in 30 participants who haven't responded wel…

This early-stage study is testing the safety and how the body processes a new rheumatoid arthritis drug called PIT565. The trial will enroll 57 adults with rheumatoid arthritis who will receive injections of the experimental medication. Researchers will monitor for side effects a…

This is a very early study to check the safety and basic effects of a new drug called LFD-200, given as a weekly injection. It will first test single and multiple doses in healthy volunteers, then test multiple weekly doses in people with moderate to severe rheumatoid arthritis. …

This study is testing whether a medication called pentoxifylline can help control the inflammation and disease activity in people with rheumatoid arthritis. It will involve 50 adults with active rheumatoid arthritis who are already taking standard arthritis medications. Researche…

This early-stage study aims to test the safety and basic effects of a new experimental drug called AZD5492 in adults with lupus, inflammatory muscle diseases, or rheumatoid arthritis. Researchers will give participants one or two doses and closely monitor them for side effects an…

This study is testing whether taking capsules containing processed stool from a healthy donor can help people newly diagnosed with certain inflammatory diseases like rheumatoid arthritis, Crohn's disease, or ulcerative colitis. About 200 participants will receive either these spe…

This study is testing whether adding an anti-inflammatory diet to standard care helps people with rheumatoid arthritis feel better and reduces their disease activity. Researchers will enroll 124 adults whose arthritis is currently stable but active, and randomly assign them to fo…

This study is testing a new drug called AZD1163 for people with moderate-to-severe rheumatoid arthritis (RA). It aims to see if the drug can safely reduce disease activity and inflammation when added to a person's current standard medications. About 320 participants will receive …

This study follows patients for up to 10 years after receiving a Persona brand knee replacement. The goal is to confirm the implant's safety, how well it works, and the benefits it provides for people with severe knee arthritis or deformities. Researchers will track pain levels, …

This study is testing whether an online wellness program can help people with conditions like rheumatoid arthritis and lupus feel less tired and improve their quality of life. Researchers will enroll 200 participants to try a 6-month online course focused on diet, gentle exercise…

This study is looking at whether adding special breathing muscle training to standard breathing exercises helps people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups of 39 patients to see if the extra training improves their ability to e…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This study aims to learn more about people with rheumatoid arthritis (RA) that doesn't respond well to standard treatments, known as 'refractory RA.' Researchers will follow 200 adults with this condition over time to observe their symptoms, immune system patterns, and quality of…

This study is testing a new data platform to collect information from 600 people getting a total knee replacement. Participants will use a sensor and app to track their knee movement and answer surveys about pain and recovery. The goal is to find unknown risks and factors that co…

This study aims to understand how the rheumatoid arthritis drug abatacept (Orencia®) affects the immune system by comparing blood samples from three groups over six months. Researchers will follow 72 people: patients starting abatacept, patients starting a different standard drug…

This study aims to find better ways to predict which advanced arthritis drug will work best for each patient, moving away from the current trial-and-error approach. It will enroll 75 adults with rheumatoid arthritis who need a new medication. Researchers will collect detailed hea…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to collect long-term data on how well shoulder replacement implants work and how safe they are over many years. It will follow up to 20,000 patients who have had or will have shoulder replacement surgery for at least 10 years. Researchers will track patients' pain…

This study aims to understand the challenges people with rheumatoid arthritis face in controlling their high blood pressure, which increases their risk of heart disease. Researchers will work with 25 participants from the Duke Health System to identify barriers and test a support…