New hope for tough arthritis cases: experimental drug enters Mid-Stage trial

NCT ID NCT07137598

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo to see if it reduces joint swelling and pain. The goal is to find a new option for controlling this chronic autoimmune disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Show contact details

Study contacts

Contact
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

APRILLUS Asistencia e Investigacion
RECRUITING

Buenos Aires, Ciudad Autonoma Buenos Aires, C1406AGA, Argentina
Accurate Clinical Management
RECRUITING

Houston, Texas, 77089, United States
Accurate Clinical Research Inc.
RECRUITING

Lake Charles, Louisiana, 70605, United States
Altoona Center For Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia
RECRUITING

Reggio Emilia, Emilia-Romagna, 42123, Italy
Barnet Hospital
RECRUITING

Barnet, EN5 3DJ, United Kingdom
Bispebjerg og Frederiksberg Hospital
RECRUITING

Frederiksberg, 2000, Denmark
CEPIC - Centro Paulista de Investigao Clnica e Servios Mdicos
RECRUITING

So Paulo, São Paulo, 04266-010, Brazil
CHU Strasbourg Hpital Hautepierre
RECRUITING

Strasbourg, Bas Rhin, 67091, France
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centro Medico Arsema
RECRUITING

Ciudad Autnoma de Buenos Aires, Buenos Aires, C1427, Argentina
Centro Mineiro de Pesquisa - CMIP
RECRUITING

Juiz de Fora, Minas Gerais, 36010-570, Brazil
Centro Privado de Medicina Familiar - Mind Out Research
RECRUITING

Ciudad Autonoma Buenos Aires, C1417EYH, Argentina
Centro de Estudos em Terapias Inovadoras ? CETI
RECRUITING

Curitiba, Paraná, 80030-110, Brazil
Centro de Investigaciones Medicas Mar Del Plata
RECRUITING

Mar del Plata, Buenos Aires, 7600, Argentina
Centro de Investigaciones Medicas Tucuman
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spó?ka Partne
RECRUITING

Elbl?g, 82-300, Poland
Centrum Medyczne Reuma Park
RECRUITING

Warsaw, 02-665, Poland
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
Doncaster Royal Infirmary
RECRUITING

Doncaster, South Yorkshire, DN2 5LT, United Kingdom
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, Lazio, 00168, Italy
HUB Erasme
RECRUITING

Brussels, 1070, Belgium
Hopital Lapeyronie
RECRUITING

Montpellier, Herault, 34295, France
Hopital Purpan
RECRUITING

Toulouse, Lot Et Garonne, 31059, France
Hopital de la Conception
RECRUITING

Marseille, Bouches-du-Rhne, 13005, France
Hospital Quironsalud Infanta Luisa
RECRUITING

Seville, 41010, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29009, Spain
Hospital So Lucas da PUCRS
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital das Clínicas FMRP-USP
RECRUITING

Ribeirão Preto, São Paulo, 14048-900, Brazil
Hpital Cochin
RECRUITING

Paris, 75014, France
IPC MT Instituto de Pesquisas Clinicas do Mato Grosso
RECRUITING

Cuiab, Mato Grosso, 78020-500, Brazil
Inland Rheumatology Clinical Trials Incorporated
RECRUITING

Upland, California, 91786, United States
Istituto Clinico Humanitas
RECRUITING

Rozzano, Lombardy, 20089, Italy
L2IP ?Instituto de Pesquisas Clínicas Ltda.
RECRUITING

Brasília, Federal District, 70200-730, Brazil
Leicester Royal Infirmary
RECRUITING

Leicester, Leicestershire, LE1 5WW, United Kingdom
Malopolskie Badania Kliniczne
RECRUITING

Krakow, 30-002, Poland
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Eleonory Reicher
RECRUITING

Warsaw, 02-637, Poland
North Tyneside General Hospital
RECRUITING

Newcastle upon Tyne, Tyne & Wear, NE29 8NH, United Kingdom
Nzoz Bif-Med
RECRUITING

Bytom, 41-902, Poland
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43203, United States
Reumatop Spolka Jawna
RECRUITING

Wroclaw, 52-210, Poland
Rheumatic Disease Center
RECRUITING

Glendale, Wisconsin, 53217, United States
Rheumazentrum Ruhrgebiet
RECRUITING

Herne, North Rhine-Westphalia, 44649, Germany
Sjllands Universitetshospital
RECRUITING

Kge, 4600, Denmark
Städtisches Klinik Dresden-Friedrichstadt
RECRUITING

Dresden, Saxony, 01067, Germany
SunValley Arthritis Center Ltd.
RECRUITING

Peoria, Arizona, 85381, United States
Tidewater Clinical Research
RECRUITING

Chesapeake, Virginia, 23320, United States
Twoja Przychodnia NCM
RECRUITING

Nowa Sól, 67-100, Poland
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
West Broward Rheumatology Associates, Inc.
RECRUITING

Tamarac, Florida, 33321, United States
Willow Rheumatology and Wellness PLLC
RECRUITING

Willowbrook, Illinois, 60527, United States
Zespol Poradni Specjalistycznych REUMED
RECRUITING

Lublin, 20-607, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.