RHEUMATOID ARTHRITIS

This early-stage study tests a single infusion of stem cells from donated umbilical cord tissue in 16 adults with moderate to severe rheumatoid arthritis that hasn't responded well to standard treatments. The main goal is to check safety and side effects over 52 weeks. Researcher…

This study tests whether adding a new drug, natrunix, to the standard treatment methotrexate helps control moderate to severe rheumatoid arthritis better than methotrexate alone. About 108 adults who have not responded well enough to methotrexate will receive weekly injections fo…

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve signals to reduce inflammation. Researchers will track how well the device works, its safety, and ease of use in everyday medical …

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on the person's weight. The goal is to see if the simpler fixed dose works just…

This study tests a new daily pill called ivarmacitinib for people with rheumatoid arthritis (RA) who did not get better with standard first treatments. The goal is to see if it can reduce joint pain and swelling and control the disease. About 100 adults with moderate to severe RA…

This study looks at whether baricitinib, a drug for rheumatoid arthritis, can improve blood clotting and cholesterol levels better than standard treatments. About 100 adults with active rheumatoid arthritis will take baricitinib or continue their usual therapy for 3 months. Resea…

This study tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are also overweight or obese. Twenty adults with active arthritis despite standard treatment will receive either dis…

This early-stage study tests a treatment called GC012F in 9 adults with difficult-to-treat rheumatoid arthritis. The therapy uses a person's own immune cells, modified to target and calm the overactive immune system. The main goal is to check safety and measure how long the cells…

This study tests an experimental injection called GenSci120 in 450 adults with moderate-to-severe rheumatoid arthritis who did not get enough relief from at least one standard medication. The goal is to see if the drug reduces joint swelling and pain better than a placebo or an e…

This early-stage study aims to check the safety and how the body processes a new experimental drug called BMS-986454 in people with rheumatoid arthritis. It will involve 46 participants who have arthritis that didn't fully respond to standard methotrexate treatment. Researchers w…

This study looks at whether combining resistance exercises with an anti-inflammatory diet can reduce pain, improve daily function, and boost quality of life in people with rheumatoid arthritis. One hundred adults with low to moderate disease activity will follow a structured prog…

This study looks at whether adding venlafaxine, a drug usually used for depression, can improve symptoms in people with rheumatoid arthritis (RA). Researchers will give 70 adults with active RA either venlafaxine or a placebo alongside their usual arthritis medications. The goal …

This study will collect medical information and biological samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. The goal is to create a database and biobank to help researchers identify biological markers and un…

This study looks at 72 adults with rheumatoid arthritis to see if certain blood markers and ultrasound images can better track disease activity. Researchers will compare patients taking JAK inhibitors with those on standard treatments. The goal is to find simpler, more accurate w…