Could a simple supplement boost knee injection results for arthritis sufferers?
NCT ID NCT07680101
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help calm nerve-related inflammation. The trial involves 80 adults with knee osteoarthritis or rheumatoid arthritis who will receive either the injections alone or the injections plus the oral supplement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Adelmidrol 2% / Hyaluronic Acid 1% (injection) and micronized/ultramicronized Palmitoylethanolamide (oral supplement)
- What this could lead to
- If successful, this combination could offer a new way to ease knee pain and improve mobility for people with osteoarthritis or rheumatoid arthritis.
- What could go wrong
- This is a small, early-stage study with only 80 participants, so results may not apply to everyone. The supplement may not provide added benefit over the injection alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEGENERATIVE JOINT DISEASE OF KNEE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Azienda Ospedaliera Universitaria Integrata Verona
Verona, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can saving the meniscus save knees from osteoarthritis?
- Can a new shoulder implant restore Pain-Free movement?
- Can a less invasive hip surgery speed up recovery?
- Which hip implant lasts longer? a Head-to-Head trial aims to find out
- Can pregnancy and neurological disease coexist safely? a new registry seeks answers
- Can group learning make biotherapy safer for arthritis patients?