RHEUMATOID ARTHRITIS

This study looks at how well a knee replacement system works for people with arthritis or other knee damage. About 299 patients will receive the implant to see if it reduces pain, improves movement, and lasts a long time. The goal is to show that most patients do well after surge…

This study looks at the T.E.S.S. V3 shoulder implant in 67 people with shoulder problems like arthritis, fractures, or rotator cuff tears. It checks how long the implant lasts and any side effects over 10 years. The goal is to confirm the implant is safe and helps with pain and m…

This study follows 200 people who received a specific shoulder replacement system to see how long it lasts and how well it works. Participants have conditions like arthritis, fractures, or rotator cuff problems. Researchers measure pain and function using standard shoulder assess…

This study is checking how safe and well a new shoulder implant, the Sidus Stem-Free Shoulder, works for people with severe shoulder arthritis. About 152 people who need a shoulder replacement are taking part. The study looks at pain, movement, and quality of life after surgery.

This study looks at how well the cemented TrendHip® hip stem performs and its safety in 119 people who had a hip replacement. It measures pain, function, and quality of life over five years. The goal is to confirm the device works as intended in everyday medical practice.

This early-stage study tests a new drug called CND261 in 47 adults with moderate to severe rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check the drug's safety and how the body handles it. Researchers will also look for signs that it mi…

This study tests whether adding an anti-TNF drug to baricitinib works better than baricitinib alone for people with rheumatoid arthritis who haven't improved with other treatments. About 160 adults aged 18-65 with active RA will be randomly assigned to one of two groups. The main…

This study tests a new treatment called CAR-T cell therapy against a standard drug, rituximab, in people with active rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if CAR-T cells are safe and can reduce harmful antibodies linked to the disease…

This study looked at how well a metal plate (A.L.P.S. Proximal Humerus Plating System) works for fixing broken upper arm bones. It included 135 adults who needed surgery for a fresh fracture. The main goal was to see how many people needed another surgery within a year due to pro…

This study follows 155 adults in France with moderate to severe rheumatoid arthritis who are starting filgotinib. Researchers will track how long people stay on the drug, how well it controls disease activity, and any side effects over two years. The goal is to see how the medici…

This study tests a small device implanted on the vagus nerve in the neck to treat moderate to severe rheumatoid arthritis. About 243 adults who haven't improved with other medications will receive either active or inactive stimulation for 12 weeks, then all will get active stimul…

This study is checking how well a new hip replacement part, the MiniMAX stem, works in 100 people who need a new hip. The main goal is to see how long the stem lasts without needing to be replaced. The study also measures how well patients can move and function after surgery usin…

This study follows 120 adults with arthritis (degenerative, rheumatoid, or post-traumatic) who receive a Zimmer Trabecular Metal Total Ankle implant. Researchers check how long the implant lasts, pain levels, and how well the ankle works over 10 years. The goal is to see if the i…

This study tests an experimental drug called LY3871801 in 164 adults with moderate-to-severe rheumatoid arthritis (RA) who have not responded well to standard treatments. The goal is to see if the drug can reduce joint swelling and pain better than a placebo. Participants will re…

This study looks at how well a new knee replacement system works in people with severe knee pain from arthritis or after a previous knee replacement failed. About 255 adults will get the new implant and be followed for up to 10 years. The goal is to see if the system improves kne…

This early-stage study tests a new drug called GS-0272 in about 55 adults with rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it at different doses. Participants will receive either the study drug or a placebo, and researchers will …

This study tests an experimental drug called LY3541860 in 35 adults with moderate-to-severe rheumatoid arthritis that did not improve enough with other medications. The goal is to see if the drug can reduce joint swelling, pain, and inflammation. Participants receive the drug for…

This study looks at how well a special hip liner works over time in people who need a hip replacement. It includes 202 adults aged 18 to 80 with conditions like arthritis or hip fractures. The main goal is to see if the liner stays in place safely and helps reduce pain and improv…

This study compares two common treatment strategies for rheumatoid arthritis (RA) to see which one works better at controlling the disease. About 340 adults with RA will be assigned to aim for either low disease activity or remission, using a treat-to-target approach. The goal is…

This study compares two types of total knee replacements: one that uses bone cement to hold the implant in place and one that does not. The goal is to see which approach provides better pain relief, function, and implant survival over time. About 300 adults with knee arthritis or…

This study follows 737 people who received the Persona knee implant to see how well it works over time. Participants had severe knee pain from conditions like arthritis or injury. The goal is to measure implant survival and improve knee function.

This study follows 600 adults with moderate to severe rheumatoid arthritis who are already prescribed a biosimilar called Tyenne (similar to tocilizumab). Researchers want to see how many patients continue the treatment for 6 and 12 months. The study does not give any new medicin…

This study tests whether the oral medication upadacitinib works better than the injected adalimumab for adults with moderate-to-severe rheumatoid arthritis who have already tried and failed one TNF inhibitor. About 480 participants will be randomly assigned to receive either drug…

This study tests an experimental drug called BGB-45035 in adults with moderate to severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. About 49 participants will receive either the drug or a placebo to see if it reduces joint pain and swelling. T…

This study is testing a new shoulder replacement system for people who need a second surgery because their first implant failed, or who have severe joint damage from arthritis, injury, or cancer. About 105 participants will receive the new implant and be followed to see how long …

This study follows over 1,300 adults with moderate to severe rheumatoid arthritis who are prescribed filgotinib as part of their normal care. Researchers will track how long patients stay on the drug, and how it affects their pain, fatigue, and daily life over two years. The goal…

This study watches for side effects in 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who receive Remsima under the skin. It aims to see how safe the injection is over time. Participants must have active disease that didn't respond…

This early-stage study tests a one-time intravenous infusion of stem cells derived from donated human umbilical cords in 9 adults with moderate-to-severe rheumatoid arthritis who have not responded well to standard treatments. The main goal is to check safety and tolerability, wh…

This study compares a new 2mL auto-injector or pre-filled syringe to the standard two 1mL injections of ianalumab in 155 adults with rheumatoid arthritis, Sjögren's disease, or lupus. The goal is to see if the new device delivers the same amount of medicine safely. Participants w…

This study is testing a new knee implant called Persona Ti-Nidium in 240 adults who need a total knee replacement due to arthritis or other knee problems. The goal is to see if the implant is safe and helps people move better and feel less pain. Participants will have surgery and…

This study follows 110 people who receive the Tornier HRS shoulder replacement system for conditions like arthritis, fractures, or rotator cuff tears. Researchers will measure pain, function, and quality of life over time. The goal is to confirm the device works safely and meets …

This study tests a new drug called LNK01001 (Zemprocitinib) in 430 adults with moderate-to-severe rheumatoid arthritis who did not get enough relief from other treatments. The drug aims to reduce joint pain and swelling by targeting inflammation. Participants will receive either …

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This study tests an experimental drug called IMVT-1402 in 120 adults with active, difficult-to-treat rheumatoid arthritis (RA) who have a specific antibody (ACPA). The goal is to see if the drug can help control disease activity better than a placebo. Participants will be monitor…

This study tracks 200 people who received a cementless knee implant (GMK Sphere) to see how well it works over time. Participants have severe knee damage from arthritis or other conditions. The goal is to measure implant survival and knee function, not to cure the underlying dise…

This study follows 777 people aged 18 to 75 who received a Persona knee implant to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers are checking how long the implant lasts, how safe it is, and how well it improves pain…

This study looks at how safe and effective the Shingrix vaccine is for people with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. About 2,000 participants will receive the vaccine or a placebo to check for disease flares an…

This study aimed to test the safety of an experimental drug called F8IL10, given as a joint injection every 4 weeks for 8 weeks, in people with rheumatoid arthritis who still have flare-ups despite standard treatments. The study was withdrawn before any participants were enrolled…

This study tests whether a culturally adapted education program can help people with rheumatoid arthritis (RA) better manage their condition and improve quality of life. About 88 adults with RA will join group sessions and individual activities focused on disease education, self-…

This study tests an online program designed to help people with inflammatory arthritis (like rheumatoid arthritis or lupus) keep their jobs. Participants get access to eLearning, an occupational therapist, and a vocational counselor. The goal is to see if the program improves wor…

This study looks at whether a 12-week high-intensity interval exercise program can improve heart function, reduce inflammation, and ease symptoms in people with rheumatoid arthritis. About 87 adults with stable, low-to-moderate disease activity will participate. The goal is to se…

This study looks at whether foot core exercises, done at home with remote guidance, can reduce foot pain and improve walking and balance in people with rheumatoid arthritis. Researchers will compare two remote methods (synchronous vs. asynchronous) in 18 adults aged 18-65. The go…

This study follows 194 people who received a specific shoulder replacement device to see how well it works over time. It includes patients with arthritis, bone death, or previous failed treatments. The goal is to collect safety and performance data for up to 10 years after surger…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study follows 25 adults with rheumatoid arthritis for one year to see how their blood samples relate to changes in disease activity. Researchers are looking for RNA signals that might predict flare-ups. Participants do not receive any treatment; the goal is simply to learn m…

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study follows 2,000 adults with rheumatoid arthritis in Japan to compare the real-world safety and effectiveness of common treatments like DMARDs and JAK inhibitors. Researchers track side effects, joint pain, and disease activity over time. Participants are already prescrib…

This study looks at how getting older changes the way rheumatoid arthritis (RA) affects people. Researchers will compare 420 RA patients and 420 healthy adults aged 55-85 to see how disease activity, thinking skills, and physical abilities change with age. The goal is to create a…

This study looks at medical records from over 500,000 Medicare patients who had major orthopedic surgeries like hip or knee replacements. The goal is to find out how often complications happen and how care can be improved. No new treatments are tested—researchers are just analyzi…

This study follows 4,000 people with rheumatoid arthritis (ages 50-75) over 10 years to learn more about their risk for heart disease, lung problems, and mental health issues. Participants get a special heart CT scan, lung tests, and questionnaires. The goal is to better identify…

This study was designed to understand how obesity changes the way the body processes etanercept, a biologic drug for arthritis. Researchers planned to measure drug levels in obese adults and children with rheumatoid or juvenile idiopathic arthritis. The study was withdrawn before…

This study aimed to see if taking a small sample of joint tissue (synovial biopsy) could help doctors choose the right biologic drug for people with rheumatoid arthritis who haven't gotten better with standard medicines. The goal was to match each patient to the most effective tr…

This study tests a new PET imaging method to see where rheumatoid arthritis (RA) is active in the body. About 10 adults with RA will receive a special tracer that highlights inflamed joints. The goal is to improve how doctors detect and monitor RA, not to treat it.

This research registry follows over 91,000 adults with rheumatoid arthritis to see how well approved treatments work and how safe they are. Participants are cared for by rheumatologists across North America. The study does not test new drugs but collects real-world data to improv…

This study looks at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug Leflunomide (ARAVA), used for rheumatoid and psoriatic arthritis. Researchers will survey about 3,500 doctors and pharmacists to see if they received and read…

This study follows 230 adults getting a hip replacement with the G7 Acetabular System to see how long the implant lasts. Participants have hip problems like arthritis or bone death. The study does not test a new treatment but collects information on implant survival and patient-r…

This study was designed to track pregnancies in women with rare autoimmune diseases like lupus, arthritis, and scleroderma. The goal was to learn about complications and improve care. However, the study was withdrawn before enrolling any participants, so no results are available.

This study gathers information from a database to see how long shoulder implants last in people with various shoulder problems like arthritis or fractures. Researchers will track if any implants need to be replaced and measure shoulder function using a standard score. The goal is…

This study looks at whether giving people with inflammatory arthritis extra support—like a list of local resources, help from a community specialist, or a nurse navigator—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have…

This study collects blood samples from about 3,000 people with rheumatoid arthritis to create a large library for research. Scientists will test the samples for biomarkers that show how active the disease is or predict side effects. Participants must already be in a registry and …

This study follows about 1,600 adults with rheumatoid arthritis (RA) over time to learn which biological markers can predict how well a drug will work or cause side effects. Researchers also aim to identify markers that show how the disease will progress. Participants receive the…