New study tests whether No-Cement knee implants outperform traditional ones
NCT ID NCT05630053
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of total knee replacement systems: one that uses cement to hold the implant in place and one that does not. Researchers will track 300 patients with knee pain from arthritis or deformity over 5 years to see which implant leads to better pain relief, function, and survival. The goal is to find out if the cementless version is a safe and effective alternative.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Persona Knee System (cementless and cemented versions)
- What this could lead to
- If successful, this could show that a cementless knee replacement works as well or better than the cemented version, potentially offering a longer-lasting option with fewer complications.
- What could go wrong
- This is a mid-sized study comparing two existing devices, not a breakthrough treatment. Results may not apply to all patients, and there are standard surgical risks like infection or implant loosening.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anderson Orthopaedic Research Institute
Alexandria, Virginia, 22306, United States
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Centura Health
Westminster, Colorado, 80023, United States
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Johns Hopkins University
Baltimore, Maryland, 21224, United States
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Lehigh Valley Hospital - Dickson City
Dickson City, Pennsylvania, 18519, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Oregon Health & Science University
Portland, Oregon, 972329, United States
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Rothman Institute
Bryn Mawr, Pennsylvania, 19010, United States
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