OSTEOARTHRITIS

This study looks at how safe and effective the Incompass Total Ankle System is for people with ankle arthritis. About 200 adults who need ankle replacement will be followed after surgery. Researchers will review X-rays and patient surveys to measure pain relief and quality of lif…

This study looks at whether giving a nutritional drink to patients who are malnourished before hip or knee replacement surgery can improve their blood markers of nutrition. About 72 adults aged 55 to 95 with osteoarthritis will take part. Researchers will measure nutrition levels…

This study tests two ways to help people with osteoarthritis manage pain: text messages to encourage joining physical activity counseling, and a walking program called Walk with Ease. Researchers want to see which strategies work best for people in communities with limited access…

This study compares SPECT-CT and MRI scans to see which is better at diagnosing painful osteoarthritis in the ankle, hindfoot, and midfoot. Researchers will enroll 132 adults with suspected arthritis to measure each scan's accuracy. The goal is to improve diagnosis and guide trea…

This study aims to develop faster and more reliable MRI scans to detect early signs of osteoarthritis and other joint diseases before they show up on X-rays. Researchers will test these new methods on 88 healthy volunteers and patients with ACL tears or early cartilage problems a…

This study tests a once-daily pill called orforglipron in 800 people who are overweight or have obesity and also have painful knee osteoarthritis. The goal is to see if the drug helps with both weight loss and knee pain over about 74 weeks. Participants are randomly assigned to r…

This study tests if heat wraps can reduce knee pain in people with osteoarthritis. About 80 adults with moderate knee pain will wear the wraps for 8 hours a day over 7 days. The main goal is to see if pain decreases after 3 days of use.

This study compares two advanced surgical techniques for total knee replacement: computer-assisted navigation and robotic-arm assistance. The goal is to see which method helps patients feel less aware of their artificial knee in daily life. About 140 adults with knee osteoarthrit…

This study tests whether using a patient's own regenerative cells can safely reduce pain and inflammation from hip osteoarthritis. Researchers will first treat 50 people, then expand to 4,000 participants. They will measure changes in pain, quality of life, and look for cartilage…

This early study tests if a procedure called arterial embolization, using a substance called Lipiodol, is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be monitored for 6 months …

This study looks at how three different levels of physical activity (45, 90, or 150 minutes per week) affect arthritis symptoms like pain and physical function. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. …

This study tests whether a special magnetic therapy (HI-PEMF) can reduce pain and improve strength in older adults with knee osteoarthritis. About 64 people aged 60 and older will receive either joint-only or joint-plus-muscle treatment, plus a home exercise program. The goal is …

This study is testing whether using a patient's own cells can safely reduce pain and inflammation from knee osteoarthritis. It will involve 4,000 participants with moderate to severe knee arthritis. Researchers will track pain, knee function, and look for cartilage regrowth using…

This study tests whether Botox injections into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either Botox, a mix of Botox and saline, or plain saline injections, pl…

This study looks at whether adding physiotherapy to a combined steroid and lubricant hip injection helps reduce pain and improve daily function more than the injection alone. It involves 100 adults aged 40-60 with mild hip arthritis, labral tears, or hip impingement. Participants…

This study tests a 6-month mobile program that combines group support, coaching, and activity tracking to help older adults with knee or hip osteoarthritis become more active and lose weight. Researchers want to see if it reduces pain interference and improves physical function. …

This study tests whether a supplement made from boswellia, turmeric, and grape extracts can reduce pain and stiffness in adults with knee or hip osteoarthritis. Thirty participants will take the supplement and a placebo for four weeks each, then report their symptoms. The goal is…

This study looks at whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants will attend exercise classes three times a week for six months, along with standard diet and behavioral health support. The study wil…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and arthritis will receive one of the two injections and be followed for up to a year. The goal is to see if the hydrogel provid…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study tests if using a patient's own cells can safely reduce pain and swelling from shoulder arthritis. First, 50 people will try the treatment, then up to 4,000 more will join. The goal is to see if the therapy helps with daily activities and might even regrow cartilage.

This study tests whether CartiPRO, an approved collagen injection, can safely reduce knee pain in people with osteoarthritis or cartilage damage. About 194 adults will receive two injections 24 weeks apart. Researchers will measure pain, knee function, and quality of life over 36…

This study tests whether an injection made from amniotic tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 160 adults with moderate knee arthritis will receive either the amniotic injection, a standard hyaluronic acid injection, or a place…

This study tests a new medicine called ALT001 for people with knee osteoarthritis. The goal is to see if it can reduce pain, improve movement, and make daily life easier. About 30 adults aged 50 to 75 will receive injections into the knee every two weeks for 12 weeks, and researc…

This phase 3 study tests a once-weekly injection called eloralintide in 900 adults who have osteoarthritis of the knee with pain and are overweight or obese. The goal is to see if the drug reduces knee pain and body weight over about 75 weeks. Participants will be randomly assign…

This study tests a new treatment called OA-SYS for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and well-tolerated. Researchers will also check if it reduces pain and improves knee function. About 400 adults aged 35 to 75 will take par…

This study tests whether sending information and making two phone calls can encourage older adults with osteoarthritis to use their free SilverSneakers exercise program. About 1,454 seniors across the U.S. who have not used SilverSneakers before will take part. The goal is to see…

This study aims to improve how doctors diagnose and treat chronic musculoskeletal pain (lasting over 12 weeks) from conditions like arthritis, fibromyalgia, and low back pain. Researchers will test a simple questionnaire and pain sensitivity assessments to see if they can identif…

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study looks at how accurately surgeons can place a new hip socket (cup) using a special computer navigation system that doesn't require extra cuts or pins. About 118 people getting a standard hip replacement will have their surgery guided by this system, and X-rays at 6 week…

This study looks at how platelet-rich plasma (PRP) injections change proteins in the blood of people with knee osteoarthritis. About 60 adults aged 18-70 will receive either a PRP injection or a saltwater placebo, and researchers will track protein changes over 26 weeks. The goal…

This study will follow 10,000 people who are having hip or knee replacement surgery to see how they recover over time. Researchers will use simple surveys to measure pain, movement, and satisfaction before and after surgery. The goal is to learn what helps patients get the best r…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…