OSTEOARTHRITIS

This study is testing a weekly injection called eloralintide in adults who have painful knee osteoarthritis and are overweight or have obesity. The main goals are to see if the treatment helps reduce knee pain and leads to weight loss. About 900 participants will be in the study …

This study is testing whether an injection made from donated amniotic fluid can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare this new injection against two others: a standard hyaluronic acid injection and a simple saline (saltwater…

This study is testing the safety and side effects of an experimental treatment called OA-SYS for people with moderate to severe knee osteoarthritis. OA-SYS is an injection containing adult stem cells, given directly into the painful knee joint. The main goal is to see if the trea…

This study tests if a simple program of mailed information and a couple of phone calls can help seniors with arthritis start using a free gym membership they already have through their insurance. Researchers want to see if using this benefit, called SilverSneakers, leads to bette…

This study is testing whether giving oral nutritional supplements to older patients who are nutritionally deficient can improve their recovery after hip or knee replacement surgery. Researchers will measure specific blood markers related to nutrition before and after surgery to s…

This study is testing a new computer navigation system designed to help surgeons place the 'cup' part of a hip replacement more accurately. It compares the planned position of the implant before surgery to its actual position after surgery. The goal is to see if this technology l…

This study is tracking the long-term safety and performance of the Incompass Total Ankle System, an FDA-cleared device already used in surgery. It will follow 200 patients for up to 10 years after their ankle replacement to see how well the implant works and how it affects their …

This study is testing whether text messages can help connect people with osteoarthritis to physical activity coaching. Researchers want to see if encouraging messages and a walking program help people manage their pain and stay active. The goal is to find better ways to deliver p…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study aims to find out which type of scan—SPECT-CT or MRI—is better at correctly diagnosing painful arthritis in the foot and ankle. Researchers will enroll 132 adults with persistent foot pain to compare how well each scan identifies the source of arthritis. The goal is to …

This study aims to develop faster, more reliable MRI scans to detect early cartilage damage and arthritis. Researchers will test these new scanning methods on healthy volunteers and people who recently tore their ACL, a group at high risk for developing arthritis. The goal is to …

This study is testing a non-invasive, high-intensity pulsed electromagnetic field (PEMF) device to see if it can reduce pain and improve strength and mobility in older adults with knee osteoarthritis. Researchers will compare applying the therapy just to the knee versus applying …

This study is testing whether injections of a person's own processed fat cells and platelet-rich plasma can safely reduce pain and inflammation from shoulder osteoarthritis. Researchers will track 50 patients' pain levels, shoulder function, and quality of life for 6 months using…

This study is testing whether a special heat wrap worn on the knee for 7 days can safely reduce pain for people with moderate osteoarthritis. About 80 adults with knee pain will use the wrap for 8 hours a day. Researchers will measure changes in pain levels and how satisfied peop…

This study is testing whether a new gel injection called Arthrosamid works better than the standard steroid injection for managing knee osteoarthritis pain. About 200 adults with moderate-to-severe knee arthritis will receive one injection of either the new gel or the standard tr…

This study is testing how well and safely a daily pill called orforglipron works for people who have obesity or are overweight and also have painful osteoarthritis in the knee. About 800 participants will take the pill or a placebo (a dummy pill) for about 74 weeks. The main goal…

This study is testing whether a treatment using a patient's own fat and blood cells can safely reduce pain and inflammation from hip osteoarthritis. Doctors will inject processed cells directly into the affected hip joint. Researchers will track pain levels, mobility, and quality…

This study tests a 6-month phone and video call program designed to help older adults with chronic knee or hip arthritis pain. The program coaches participants on increasing daily movement, reducing sitting time, and healthy eating to manage weight. Researchers want to see if thi…

This study is testing whether adding physiotherapy to a specific hip injection works better than the injection alone for reducing pain and improving function. It is for adults aged 40-60 with mild hip arthritis or related injuries who want to avoid surgery. The goal is to see if …

This study is testing whether a natural supplement containing frankincense, turmeric, and grape extracts can help reduce pain and stiffness in people with knee or hip osteoarthritis. Thirty adults with moderate osteoarthritis will take either the supplement or a placebo for four …

This study is testing a free, 3-month virtual coaching program designed for people waiting for hip or knee replacement surgery. The program aims to help participants stay active, manage pain, and reduce feelings of loneliness while they wait. Researchers want to see if the progra…

This pilot study is testing whether a minimally invasive procedure called geniculate artery embolization, when added to standard care (physical therapy and medications), provides better and longer-lasting pain relief for knee osteoarthritis than standard care alone. Researchers w…

This study is testing whether injections made from a patient's own fat and blood cells can safely reduce pain and inflammation from knee osteoarthritis. It aims to see if this treatment can improve knee function, quality of life, and potentially delay the need for knee replacemen…

This study is testing if a targeted injection to numb specific nerves around the knee (a genicular nerve block) can help people with chronic knee osteoarthritis. Researchers want to see if this procedure reduces pain, improves quality of life, and also helps with joint position s…

This study is testing whether a program of low-impact group exercise, combined with diet advice and mental health support, can help reduce pain for people with osteoarthritis in their knees, hips, or ankles. It will enroll up to 10,000 adults who can commit to attending classes t…

This study is testing whether a new procedure using tiny, dissolvable beads injected into knee arteries works better than standard steroid injections for reducing arthritis pain. About 89 adults with moderate to severe knee osteoarthritis pain that hasn't improved with other trea…

This study is testing whether a collagen-based injection called CartiPRO can safely provide long-term relief from knee pain caused by osteoarthritis. About 194 adults with knee pain will receive either CartiPRO or a standard injection, with a second dose given six months later. R…

This study aims to discover what proteins in the blood change after a person receives a platelet-rich plasma (PRP) injection for knee osteoarthritis. Researchers will compare these changes to a placebo (saltwater) injection in 60 participants aged 18-70. The main goal is to under…