OSTEOARTHRITIS

This early-stage trial tests whether a single injection of XytriX, made from umbilical cord stem cells, can safely improve pain and function in adults with knee osteoarthritis. About 75 participants with mild to severe knee arthritis will receive the injection and be monitored fo…

This study tests whether a virtual, team-based lifestyle program works as well as in-person physiotherapy for people with chronic muscle or joint pain living in rural areas. About 354 adults with conditions like back, knee, or hip pain will receive up to 10 sessions over six mont…

This study tests whether applying bee venom gel to the skin with ultrasound (phonophoresis) can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40 to 75 with moderate to severe knee pain will be randomly assigned to receive either the bee v…

This study looks at whether two common diabetes medications, GLP1 and SGLT2, can reduce joint pain and stiffness in people with type 2 diabetes and osteoarthritis. About 390 adults over 50 who have taken one of these drugs for at least a year will be compared to those on standard…

This study compares robotic-assisted knee replacement surgery to the standard manual procedure for people with knee osteoarthritis. About 346 adults will be randomly assigned to one of the two surgeries and followed for a year to see which provides better pain relief, function, a…

This study looks at whether a carefully planned ketogenic diet can reduce pain and improve thinking in people who have both osteoarthritis and mild cognitive impairment. Ten adults will follow the diet under supervision, and researchers will check their pain, physical function, a…

This study tests whether taking a powder made from the fruit of a rose plant (Rosa roxburghii) can help people recover better after total knee replacement surgery for osteoarthritis. About 184 adults will take either the rose powder or a placebo daily for 30 days after surgery. R…

This study tests a gel called Sensovisc, injected into the hip joint, to see if it safely reduces pain and improves movement in people with hip osteoarthritis. About 25 adults with moderate hip arthritis will receive the injection and be monitored for 6 months. The goal is to rel…

This study compares a new tablet called Laybon to an existing one (Layla) for knee osteoarthritis pain. About 172 adults aged 40 to 80 with knee arthritis will take either Laybon or Layla for 8 weeks. The main goal is to see if Laybon works as well as Layla at reducing knee pain …

This study looks at how people make decisions about imaging tests like X-rays or MRIs for common muscle and joint issues. About 220 adults with conditions like arthritis or carpal tunnel syndrome will either have a short conversation about the test's pros and cons or read brief i…

This study will use a high-tech blood test (mass spectrometry) to look at different immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors screen for and diagnose these conditions earlier. No new tr…

This study looks at 20 people with severe temporomandibular joint (TMJ) disorders who need surgery. Researchers will examine removed tissue for signs of bacteria and other clues to understand what causes these painful jaw conditions. The goal is to learn more about the disease, n…

This study will measure how many people with knee osteoarthritis also have sarcopenia (age-related muscle loss). Researchers will assess muscle mass, strength, and physical performance in 224 adults aged 40 and older in Upper Egypt. They will also look at nutrition and quality of…

This study aims to describe different types of joint tissue inflammation in people with early osteoarthritis. Researchers will take small tissue samples from the knee using a needle guided by ultrasound, along with blood samples, from 30 participants. The goal is to better unders…