Could a simple pill boost knee replacement recovery?
NCT ID NCT06894719
First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This study tests whether taking the drug tranexamic acid for up to 7 days after total knee replacement can improve pain, function, and knee movement. About 351 adults having knee surgery will be randomly assigned to take the drug for 3 days, 7 days, or a placebo. Researchers will track their recovery over 2 years, focusing on results at 6 weeks and 90 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tranexamic acid
- What this could lead to
- If it works, this could lead to a simple, low-cost way to improve recovery and reduce pain after knee replacement surgery.
- What could go wrong
- This is a Phase 4 trial, so the drug is already approved for other uses, but it may not show meaningful benefits over placebo. Risks include blood clots, though patients with recent clots are excluded.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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