Which nerve drug wins the battle against Post-Surgical knee pain?

NCT ID NCT06328062

Recruiting now Symptom relief Sponsor: Thammasat University Hospital Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial asks whether mirogabalin or pregabalin provides better pain relief after total knee replacement surgery. Adults aged 50-85 with knee osteoarthritis will take one of the two drugs for two weeks after surgery. Researchers will measure pain scores, morphine use, and knee function to see if one drug offers a clear advantage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mirogabalin and pregabalin
What this could lead to: If mirogabalin proves better, it could offer a more effective pain relief option after knee replacement surgery, potentially reducing opioid use and improving recovery.
What could go wrong: This is a small, early-stage trial, and results may not apply to everyone. Both drugs can cause side effects like dizziness and sleepiness, and the difference in pain relief may be minimal.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS PAIN, POSTOPERATIVE TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Thammasat University Hospital
RECRUITING

Khlong Luang, Changwat Pathum Thani, 12120, Thailand

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