PAIN, POSTOPERATIVE

This large Phase 3 trial tests whether giving lidocaine (a numbing medicine) through an IV during breast cancer surgery can prevent persistent pain that often follows. Over 1,600 adults having lumpectomy or mastectomy will be randomly assigned to receive lidocaine or a placebo. T…

This study tests whether using quilting stitches (which attach skin to muscle) with just one drain under the arm works as well as using two drains after mastectomy. The goal is to prevent seroma (fluid buildup), infection, and pain. Sixty women having a modified radical mastectom…

This study tests whether freezing certain nerves (cryoablation) during surgery to fix broken ribs can help control pain better than surgery alone. About 80 adults with multiple broken ribs will be randomly assigned to receive either the standard surgery or surgery plus nerve free…

This pilot study tests if patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) using a pump, instead of waiting for a nurse to bring pills. About 24 adults will be enrolled, and researchers will measure how many agree…

This trial tests whether a surgeon-given nerve block (TAP block) can improve pain control after a cesarean section. The block uses a long-acting numbing medicine injected into the abdominal wall. Researchers want to see if it reduces the need for narcotics, helps women move soone…

This trial compares two ultrasound-guided nerve blocks—the rhomboid intercostal block and the serratus posterior superior intercostal plane block—for controlling pain after video-assisted lung surgery. Ninety adults undergoing elective VATS will receive one of the two blocks, and…

This study compares a combination of ibuprofen and acetaminophen to the opioid oxycodone for managing pain after thumb surgery (trapeziectomy) for osteoarthritis. About 121 adults will be randomly assigned to one of the two pain regimens and tracked for 30 days. The goal is to se…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) provides better pain relief than the standard version after minimally invasive chest surgery. Forty adults undergoing thoracoscopic procedures will receive one of the two drugs inj…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests whether a single injection of morphine into the spinal fluid can reduce pain and the need for other painkillers after video-assisted or robotic lung surgery. About 90 adults undergoing elective lung surgery will be randomly assigned to receive either the morphine…

This study tests whether a brief mindfulness or biofeedback session before shoulder surgery can reduce pain, improve shoulder function, sleep, mood, and quality of life after the operation. About 120 people with long-term shoulder pain will be randomly assigned to one of three sh…

This study tests a standardized anesthesia plan for children aged 14 and older undergoing LeFort jaw surgery. Researchers will compare pain levels, hospital stay length, and need for intensive care between a group receiving the new protocol and a group from past records. The goal…

This study tests whether adding either dexamethasone or dexmedetomidine to a standard numbing medicine (bupivacaine) in a nerve block can provide longer pain relief after abdominal surgery. About 96 adults aged 25-65 will be enrolled. The goal is to reduce pain and the need for s…

This study tests a device called the Nociception Level (NOL) monitor, which tracks pain signals during surgery. The goal is to help doctors give the right amount of pain medicine, avoiding too much or too little. The trial will include 60 adults having robotic colorectal surgery …

This study compares two numbing drug recipes for a nerve block given before leg surgery. One group gets a mix of lidocaine and bupivacaine, while the other gets bupivacaine alone. Researchers want to see which combination works faster and provides better pain control after the op…

This study compares two types of nerve blocks—PENG block and lumbar erector spinae plane block—to see which one better controls pain after total hip replacement. Fifty-two adults undergoing hip replacement under spinal anesthesia will be randomly assigned to receive one of the tw…

This study tests whether adding a specific nerve block (PIFB) to standard pain management helps patients recover faster after open-heart surgery. It compares two types of nerve blocks in 123 adults undergoing elective heart surgery. The goal is to see if one block is at least as …

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether avoiding opioids during breast cancer surgery can reduce pain and side effects afterward. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard anesthesia. Researchers will measure pain leve…

This study tests whether taking zolpidem (Ambien) before and after lumbar spine fusion surgery can reduce pain and improve function. 140 adults with degenerative lumbar disease will receive either zolpidem or a placebo. Researchers will measure pain levels and disability up to 6 …

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedu…

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This study tests whether a nerve block called an inter-semispinalis plane block can help people use fewer opioid painkillers after posterior cervical spine surgery. About 60 participants will be randomly assigned to receive either the nerve block plus standard pain medication or …

This study tests whether a pectoral nerve block (PECS) given before surgery can lower pain and the need for morphine after a heart device implant in children aged 3 to 18. Half the children will get the nerve block plus standard wound numbing, while the other half get only wound …

This study tests a new nerve block called BiFeS against the standard iPACK block for pain after knee replacement surgery. 88 adults having a knee replacement will be randomly assigned to receive one of the two blocks. The goal is to see which provides better pain relief and helps…

This study compares two common ways to manage pain after surgery: NSAIDs (like ibuprofen) plus acetaminophen, or low-dose opioids (like oxycodone) plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will be randomly assigned to o…

This study compares a new, less invasive surgical technique to standard open surgery for placing screws in the neck and upper back bones. The goal is to see if the new approach reduces pain and improves recovery. About 76 adults with conditions like fractures, instability, or tum…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their parents prepare for surgery. The app provides culturally tailored information and coping skills to reduce anxiety and pain. Researchers will compare the app to standard care in 120…

This study looks at whether a 12-week virtual dance program can improve quality of life and reduce pain, fatigue, and body image issues in breast cancer survivors who have ongoing pain after surgery. Thirty participants who had a lumpectomy or mastectomy and still have moderate t…

This study tests whether a continuous pump delivering numbing medicine into the belly can reduce pain and the need for narcotics after minimally invasive hysterectomy. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either a numbing drug…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study looks at the best way to manage pain in young children after dental surgery done under general anesthesia. It compares giving ibuprofen alone, alternating ibuprofen and acetaminophen, or giving both together. About 75 children will take part, and their pain will be mea…

This study compares two ultrasound-guided nerve blocks—Erector Spinae Plane Block and Quadro-Iliac Plane Block—for managing pain after lumbar spine surgery. Eighty adults aged 18 to 65 will receive one of the blocks at the end of surgery. The main goal is to see which block reduc…

This study tests whether a specific injection technique called erector spinae plane block (ESPB) reduces pain and opioid use after lumbar spinal fusion better than standard subcutaneous anesthesia. Researchers will enroll 66 adults scheduled for one- or two-level lumbar fusion. P…

This study tests whether injecting a numbing medication (bupivacaine) near a nerve cluster in the nose can reduce pain after minimally invasive pituitary tumor removal. About 108 adults will be randomly assigned to receive the nerve block, a placebo (saline), or no extra injectio…

This study tests if a long-lasting painkiller called Exparel can reduce pain and the need for strong narcotic pain pills in children aged 13 and older after knee surgery. About 100 participants will receive either Exparel plus a standard painkiller or the standard painkiller alon…

This study compares two types of nerve blocks for pain after kidney transplant surgery. One uses a single injection of long-lasting pain medicine, and the other uses a continuous drip through a small tube. The goal is to see which method reduces the need for opioid painkillers an…

This study compares opioid (Norco) and non-opioid (ibuprofen and acetaminophen) pain medications in 148 adults undergoing knee arthroscopy. Participants take one tablet up to four times daily for seven days after surgery. The goal is to see if non-opioids provide similar pain rel…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief with faster recovery. About 128 adults undergoing elec…

This study looks at whether taking a 600 mg dose of gabapentin two hours before wisdom tooth surgery can lower pain and the amount of opioid painkillers needed afterward. About 98 adults will be randomly assigned to receive either gabapentin or a placebo. Researchers will track p…

This study is testing whether a device that sends gentle magnetic pulses (PEMF therapy) can help reduce pain after shoulder or knee surgery. About 76 adults having these surgeries will use the device or a fake one for 10 days after their operation. Researchers will measure pain l…

This study compares giving methadone as a pill before heart surgery versus through an IV during surgery. Researchers want to see which method reduces pain and the amount of extra opioids needed in the days after surgery. About 100 adults having planned heart surgery will take par…

This study tests a device called VibraCool that uses cooling and vibration to reduce pain after ACL knee surgery. The goal is to see if it can lower pain scores and help people stop taking opioid pain pills sooner. About 130 adults who had ACL reconstruction will use the device a…

This study tests whether replacing opioids with a non-opioid drug (dexmedetomidine) and adding person-centred care can improve recovery and reduce opioid use in 220 adults undergoing obesity surgery. Participants are randomly assigned to either the opioid-free approach or standar…

This study tests whether adding dexmedetomidine to the standard painkiller bupivacaine in a nerve block (TAP block) provides better pain relief after abdominal surgery. 80 adults will be randomly assigned to receive either the combo or bupivacaine alone. Pain levels, sedation, an…

This study tests whether a gentle, non-invasive device placed on the ear can help reduce pain after lumbar (lower back) surgery. The device stimulates nerves in the ear to change how the brain processes pain. Researchers will enroll 20 adults having back surgery to see if this ap…

This pilot study tests a new device that only releases opioid pills at set times after spine surgery, aiming to reduce misuse and side effects. Half of the 30 participants will use the device and an app, while the other half get a standard pill bottle and app. Researchers will tr…

This study tests two methods of delivering local anesthetic through a nerve block catheter after surgery: a steady continuous drip or scheduled small bursts (boluses). Researchers want to see which approach reduces pain and the need for opioid painkillers. About 240 adults having…

This study compares a single dose of methadone (a long-acting opioid) given during surgery to standard short-acting opioids for pain relief after tonsillectomy in children ages 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery roo…

This study compares two types of nerve blocks—Quadratus Lumborum Block and Transversalis Fascia Block—to see which provides better pain relief after inguinal hernia surgery. Sixty adults aged 18-65 will be enrolled. The main goal is to measure how long it takes before patients ne…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This study compares standard pain management to a special nerve block called PENG in 70 adults having hip fracture surgery. The goal is to see if the block reduces pain, the need for extra painkillers, and helps patients get moving faster. Researchers will also check for side eff…

This study looks at whether giving children gabapentin before and after chest surgery can reduce their need for strong painkillers like morphine. About 60 children under 18 having heart or lung surgery will take part. The goal is to see if gabapentin helps control pain with fewer…

This study compares aloe vera gel dressings to standard paraffin-based dressings for pain relief at the donor site after skin graft surgery. About 72 adults aged 18-60 will receive one of the two dressings, and their pain will be measured on day 7 using a standard pain scale. The…

This study compares two types of nerve blocks—sacral erector spinae plane block and caudal block—to see which provides better pain relief after hypospadias repair in boys aged 1 to 5. Seventy children will receive one of the two blocks along with standard care. Researchers will m…

This study will compare pain levels after three different surgical methods for removing lymph nodes in the neck (lateral neck dissection) in people with thyroid cancer. The three methods are robotic surgery, endoscopic surgery, and traditional open surgery. Researchers will measu…

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study is observing 60 people who will have their bladder removed (cystectomy) using a robot-assisted technique. Researchers want to measure how much blood is lost during surgery, how much pain patients feel afterward, and how many need blood transfusions. The goal is to gath…