PAIN, POSTOPERATIVE

This study compares two ways to prevent seroma (fluid buildup) after mastectomy: using quilting stitches with two drains versus quilting stitches with just one drain. About 60 women having breast cancer surgery will take part. The goal is to see if one drain works as well as two,…

This large international study is testing if giving an intravenous lidocaine (a numbing medicine) drip during and right after breast cancer surgery can prevent patients from developing long-lasting pain months later. About 1,600 patients will be randomly assigned to receive eithe…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief, helping patients recover faster. About 128 adults und…

This study tests a device called VibraCool that uses cooling and vibration to reduce pain after ACL knee reconstruction. About 130 adults who had ACL surgery will use the device at home. The goal is to see if it lowers pain scores and helps people stop taking opioid pain pills so…

This study compares two pain relief methods for people recovering from abdominal surgery. One group gets a standard numbing drug (bupivacaine) alone, while the other gets it mixed with a sedative (dexmedetomidine). The goal is to see if the combo provides better pain control and …

This study looks at whether a 12-week virtual dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who have ongoing pain after surgery. About 30 adults who had a lumpectomy or mastectomy and still have moderate to severe pain will ta…

This study compares a single dose of methadone (a long-acting opioid) to standard short-acting opioids for pain control after tonsillectomy in children aged 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery room. About 440 childre…

This study tests whether applying a steroid during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having a 1- or 2-level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track opioid use, hos…

This study looks at two methods of delivering pain medicine through a nerve block after surgery: a steady drip or scheduled doses. The goal is to find which approach better controls pain and reduces the need for strong painkillers. About 240 adults having surgery will take part.

This study looks at whether giving children gabapentin before and after chest surgery can reduce the amount of strong painkillers (opioids) they need. About 60 children under 18 having heart or lung surgery will take part. If it works, this could mean fewer side effects and less …

This study tests whether freezing certain nerves during surgery to fix broken ribs can provide better pain relief than surgery alone. About 80 adults with multiple rib fractures will be randomly assigned to receive either standard surgery or surgery plus nerve freezing. The main …

This study compares two types of nerve blocks to manage pain in boys aged 1 to 5 years after hypospadias repair surgery. One block targets the sacral erector spinae area, the other is a standard caudal block. Researchers will measure pain levels, need for extra pain medicine, and…

This study tests a new device that only gives you a painkiller after you report your pain level on a phone app. The goal is to help people use opioids more safely after spine surgery and reduce the risk of addiction or side effects. About 30 adults having back surgery will take p…

This study tests if a targeted back muscle injection (ESPB) works better than a standard skin injection for pain control after lumbar spinal fusion. Researchers will track pain levels and opioid use in 66 adults for two weeks after surgery. The goal is to see if the ESPB method l…

This study tests whether a special nerve block (PIFB) can improve recovery after open-heart surgery. About 123 adults having planned heart surgery will be randomly assigned to one of two pain-block methods. The goal is to see if one method helps patients feel better and recover f…

This study tests whether giving a steady drip of pain medicine into the belly during and after minimally invasive hysterectomy can lower pain and reduce the need for strong narcotics. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive eithe…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery for controlling pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much extra pain medicine pa…

This study tests a new, less invasive way to place screws in the neck spine (cervical spine) compared to the usual open surgery. About 76 adults with cervical spine disease will be randomly assigned to one of the two methods. The main goal is to see if the new approach reduces pa…

This study tests if a long-lasting painkiller called Exparel can better control pain and reduce the need for strong narcotic pain pills in children and teens after MPFL knee reconstruction surgery. About 100 participants aged 13 and older will receive either Exparel plus a standa…

This study tests a new nerve block method (BiFeS) against a standard one (iPACK) for pain after knee replacement surgery. About 88 adults having a knee replaced will receive one of the two blocks, plus a common nerve block. Researchers will measure pain scores, painkiller use, an…

This early study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) instead of waiting for a nurse to bring pills. About 24 adults will be enrolled to see if this approach is practical and acceptable. …

This study tests a non-invasive device placed on the ear that uses mild electrical pulses to help manage pain after lower back surgery. The goal is to see if this approach can lower pain scores and reduce the need for opioid painkillers. About 20 adults having lumbar spine surger…

This study tests whether a special nerve block (QL block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 80 adults having a planned hip replacement will take part. The goal is to see if this block helps people feel better and get moving s…

This study tests two different numbing injections for pain after kidney transplant surgery. One uses a continuous drip of medicine through small tubes, the other a single long-lasting shot. The goal is to see which method reduces the need for strong painkillers like opioids. Abou…

This study tests whether a mix of two numbing drugs (lidocaine and bupivacaine) works faster and better than one drug alone for nerve blocks in leg surgery. About 40 adults having elective below-knee surgery will receive one of the two treatments before surgery. Researchers will …

This study compares a new local numbing method (PENG block) to standard spinal anesthesia for adults having hip replacement after a fracture. The goal is to see if the new technique controls pain just as well while allowing earlier leg movement and causing less nausea. About 100 …

This study tests whether taking a single 600 mg dose of gabapentin two hours before wisdom tooth extraction can lessen pain during and after the procedure, and reduce the need for opioid painkillers. About 98 adults will be randomly assigned to receive either gabapentin or a plac…

This study tests whether a pectoral nerve block given before surgery can lower the need for strong painkillers after heart device implantation in children aged 3 to 18. Half the children will get the nerve block plus standard numbing medicine, while the other half gets standard c…

This study is testing a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their families prepare for surgery and recover with less pain and anxiety. The app provides information, coping skills, and support in a culturally adapted format. Researchers will …

This study compares standard pain management to a special nerve block (PENG block) for people having hip fracture surgery. Researchers want to see if the block reduces pain, the need for extra painkillers, and helps patients get out of bed and walk sooner. The trial will enroll 7…

This study tests whether avoiding opioids during and after obesity surgery can improve recovery and reduce side effects. About 220 adults having laparoscopic obesity surgery will be randomly assigned to opioid-free care (with or without personalized support) or standard opioid-ba…

This study tests different doses of a long-lasting painkiller (liposomal bupivacaine) injected near the knee nerve to reduce pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to one of three doses. The goal is to find the do…

This study tests whether a numbing injection (bupivacaine) given during pituitary tumor surgery can reduce pain afterward. About 108 adults will be randomly assigned to receive the nerve block, a placebo, or no extra injection. Researchers will measure pain levels and the need fo…

This study tests whether a nerve block can help people who have neck surgery use fewer opioid painkillers and feel less pain. About 60 adults having posterior cervical spine surgery will be randomly assigned to receive either standard pain medication alone or standard medication …

This study tests whether a single spinal injection of morphine before lung surgery can reduce pain and the need for other painkillers afterward. About 90 adults having video-assisted or robotic lung surgery will be randomly assigned to receive either the morphine shot or a placeb…

This study looks at whether non-narcotic pain medications work as well as opioids for pain after knee arthroscopy. About 148 adults having knee surgery will be randomly assigned to receive either opioids or non-opioids for pain relief. The goal is to find safer ways to manage pai…

This study compares two types of nerve blocks—Quadratus Lumborum Block and Transversalis Fascia Block—to see which provides better pain relief after inguinal hernia surgery. Sixty adults aged 18-65 will be enrolled. The main goal is to measure how long it takes before patients ne…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the patch or a placebo, along with standard pain care…

This study compares aloe vera gel dressings to standard paraffin-based dressings for pain relief at the donor site after skin graft surgery. About 72 adults aged 18-60 will receive one of the two dressings, and their pain will be measured on day 7 using a standard pain scale. The…

This study compares two common pain medicine combinations after surgery: NSAIDs (like ibuprofen) plus acetaminophen (Tylenol) versus low-dose opioids plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will take part. The goal is…

This study tests whether a device that creates a pulsed magnetic field (PEMF) can help reduce pain after knee or shoulder surgery. About 76 adults will use the device or a fake one for 10 days after their operation. Researchers will measure pain levels and how much pain medicine …

This study compares two different nerve-blocking techniques for pain relief after spinal fusion surgery. Researchers will test both methods on 80 patients to see which provides better pain control and recovery. The goal is to help patients feel less pain after surgery while reduc…

This study is testing if a specific nerve block injection can better control pain for people getting a pacemaker or defibrillator implanted. 60 patients will be randomly assigned to receive either the real numbing injection or a placebo (saltwater) shot. Researchers will measure …

This study aims to find the most effective way to manage pain in young children after they have dental surgery under general anesthesia. Researchers will compare three different pain medication schedules using common over-the-counter drugs: ibuprofen alone, alternating ibuprofen …

This study looks at how pain signals in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye microscopes to track healing in 60 people aged 8-35. The goal is to understand pain bet…

This study watches 60 people who are having their bladder removed with robot assistance. Researchers measure blood loss, pain, and how many blood transfusions are needed. The goal is to learn more, not to test a new treatment.

This study looks at 120 children aged 2-18 having ear, nose, or throat surgery. Researchers want to see if avoiding opioids during anesthesia lowers the chance of confusion and agitation after surgery. They will also check pain levels and satisfaction. The goal is to find a safer…