Brain and eye scans reveal how pain heals after cornea surgery

NCT ID NCT04439552

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better manage pain and recovery after corneal crosslinking for keratoconus.
What could go wrong
This is an observational study, not a treatment trial. It is small (60 participants) and may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

Acute Pain Chronic Pain chronic pain syndrome corneal disorder Corneal Injuries injury Intraoperative Complications keratoconus Pain, Postoperative Surgical Wound

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Boston Children's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

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