PAIN, CHRONIC

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study tests whether giving the numbing drug lidocaine through a vein during breast cancer surgery can prevent persistent pain that often lasts for months after the operation. About 1,600 adults having a lumpectomy or mastectomy will be randomly assigned to receive either lid…

This study tests whether a stellate ganglion block (an injection near nerves in the neck) given before mastectomy can prevent depression and chronic pain after surgery. 140 women with breast cancer will be enrolled. The goal is to reduce the need for antidepressants and improve r…

This study tests whether a small, home-used device that stimulates a nerve in the ear can safely help young adults (ages 18–29) manage pain and other symptoms of irritable bowel syndrome (IBS). About 80 participants will use either the active device or a sham version twice daily …

This study tests a new approach called Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT teaches the brain to reinterpret pain signals, aiming to reduce pain without medication. About 110 participants will be randomly assigned t…

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study tests two experimental drugs (siltuximab and erenumab) to see if they can safely reduce chronic pain in people with schwannomatosis, a rare condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either the drug or a placeb…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of long-term breast pain. Researchers will compare two groups of 230 breast cancer patients: one receiving opioid-free anesthesia and the other receiving standard opioid-based anesthesia.…

This study is testing a mobile app called Diet4painrelief that gives personalized nutrition advice to people with chronic pain who are also overweight. About 200 adults will either get standard pain rehab or rehab plus the app. Researchers will check if the app helps improve diet…

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study compares two online programs for people with chronic pain: an 8-week cognitive behavioral therapy course and a single 2-hour pain relief skills class. Researchers want to see if the shorter class works as well as the longer one. The study involves 1,650 adults with con…

This study looks at how teens aged 11-21 with chronic pain perceive body signals (like hunger or heartbeat) and how well they function in daily life. Researchers will compare these measures before and after the teens complete an occupational therapy plan. The goal is to understan…

This study looks at how sleep is different in teenagers (ages 15-17) who have had pain for more than 3 months. Researchers will test a calming relaxation technique done before bed to see if it helps improve sleep quality and how the brain processes emotions during sleep. The goal…

This study follows 20,000 adolescents aged 12-17 who receive opioid painkillers after major surgery. Researchers want to identify early warning signs that could lead to opioid use disorder within the first year. Participants complete surveys and allow access to their medical reco…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to notice signs of pain and talk about it with doctors. The study …

This study looks at how pain signals in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye microscopes to track healing in 60 people aged 8-35. The goal is to understand pain bet…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study looks at whether taking prescription opioids for chronic pain causes changes in the brain structure of adults aged 65 and older. Researchers will use MRI scans to compare brain health in people who take opioids versus those who do not. The goal is to understand the ris…