PAIN, CHRONIC

This study is evaluating a telephone support program called SUSTAIN, designed to help manage depression, anxiety, and chronic pain in older adults. The program provides check-in calls, education, and care coordination for 4,000 seniors in Pennsylvania. Researchers want to see how…

This study is testing if a temporary spinal cord stimulator can help people with type 2 diabetes who have painful nerve damage in their legs. Researchers want to see if the device not only reduces pain but also improves blood circulation and artery health in the lower limbs. The …

This study is testing whether adding personalized nutrition advice through a smartphone app can improve standard pain rehabilitation. It will involve 200 adults with chronic pain and a higher body weight. Researchers will check if the app is easy to use and if it helps with pain,…

This study aims to improve how chronic pain is detected and treated in people who have survived torture. Researchers will test if adding a simple pain questionnaire to a standard medical exam can dramatically improve pain detection. They will also explore what pain treatments are…

This large international study is testing if giving an intravenous drug called lidocaine during breast cancer surgery can prevent patients from developing long-lasting pain months later. Over 1,600 patients will be randomly assigned to receive either the lidocaine infusion or a p…

This study is testing if a simple nerve-block injection in the neck, given before breast cancer surgery, can prevent depression and chronic pain from developing afterward. It will involve 140 women undergoing a mastectomy. The goal is to see if this preemptive approach reduces th…

This study is testing two different drugs to see if they can safely reduce chronic pain in adults with schwannomatosis, a rare genetic condition that causes painful nerve tumors. Up to 40 participants will be randomly assigned to receive either an active drug or a placebo for a p…

This study is testing whether a home-based device that gently stimulates a nerve in the ear can help young adults with Irritable Bowel Syndrome (IBS) manage their pain and other symptoms like anxiety and fatigue. Researchers will compare a real stimulation device to a fake one to…

This study is comparing two online programs to see which works better for managing chronic pain. One is an 8-week cognitive behavioral therapy course, and the other is a single 2-hour skills class. Researchers at Stanford University are recruiting 1,650 adults with ongoing pain t…

This study aims to understand sleep patterns in teenagers with long-lasting pain and test if a simple pre-sleep relaxation technique can improve their sleep quality and help them manage pain. Researchers will measure sleep at home using portable devices over two nights. The study…

This study is testing a phone-based training program called PICT for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to spot signs of pain in their loved ones and how to talk about it effectively with healthcare providers. Res…

This is a small, early-stage study to see if a new pain relief method is practical for people with broken ribs. The method, called cryoneurolysis, uses extreme cold to temporarily freeze the nerves that send pain signals from the broken ribs. Researchers will enroll 24 patients t…

This study is testing whether a psychological therapy called Pain Reprocessing Therapy (PRT) can help adults who still have knee pain months after knee replacement surgery. Participants will be randomly assigned to receive either eight weekly video therapy sessions (PRT) or conti…

This study is testing whether a yoga-based occupational therapy program can help teenagers with chronic pain. Researchers want to see if the therapy improves the teens' awareness of their body's signals and their ability to do daily activities. About 49 adolescents, aged 11 to 21…

This study compares two anesthesia methods during breast cancer surgery to see which better prevents long-term pain. Researchers will follow 230 patients for one year after mastectomy, measuring pain levels and psychological factors. One group receives traditional opioid-based an…

This study aims to understand why some teenagers develop problems with opioid painkillers after surgery. Researchers will follow 20,000 teens and a parent for a year after a major operation to identify early warning signs. The goal is to gather information that could lead to bett…

This study aims to understand why some patients develop long-term pain after a common eye surgery for keratoconus. Researchers will use brain scans and special eye imaging to track how pain signals change and how nerves in the eye heal after the procedure. The goal is to learn ho…

This study aims to understand if taking prescription opioids for chronic pain causes changes in the brain structure of adults aged 65 and older. Researchers will enroll 200 people with ongoing knee or shoulder pain. Half will receive a real opioid pain medication for 6 weeks, and…