Can Opioid-Free anesthesia stop chronic pain after breast cancer surgery?

NCT ID NCT05146778

Recruiting now Symptom relief Sponsor: Gangnam Severance Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psychological factors affect pain outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Opioid-free anesthesia (dexmedetomidine and lidocaine)
What this could lead to: If it works, this could offer a way to reduce long-term pain after mastectomy without using opioids.
What could go wrong: This is a small, early-stage trial. The approach may not reduce pain better than standard care, and individual responses may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Chronic Pain chronic pain syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER MASTECTOMY PAIN POST OPERATIVE PAIN, CHRONIC

Contacts and locations

Locations

Gangnam Severance Hospital
RECRUITING

Seoul, 135270, South Korea

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