Can Opioid-Free anesthesia stop chronic pain after breast cancer surgery?
NCT ID NCT05146778
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psychological factors affect pain outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Opioid-free anesthesia (dexmedetomidine and lidocaine)
What this could lead to
If it works, this could offer a way to reduce long-term pain after mastectomy without using opioids.
What could go wrong
This is a small, early-stage trial. The approach may not reduce pain better than standard care, and individual responses may vary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Gangnam Severance Hospital
RECRUITINGSeoul, 135270, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••