MASTECTOMY

This study tests if a safe green dye (indocyanine green) can help surgeons find cancer-spreading lymph nodes through the same cut used for mastectomy, avoiding a separate armpit incision. About 90 women with early breast cancer will receive the dye during surgery. The goal is to …

This study tests whether a stellate ganglion block (an injection near nerves in the neck) given before mastectomy can prevent depression and chronic pain after surgery. 140 women with breast cancer will be enrolled. The goal is to reduce the need for antidepressants and improve r…

This study tests two different nerve-blocking techniques to see which one works better for pain after mastectomy (breast removal surgery). About 66 women having this surgery will receive one of the two blocks before the operation. Researchers will measure pain levels, how soon pa…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of long-term breast pain. Researchers will compare two groups of 230 breast cancer patients: one receiving opioid-free anesthesia and the other receiving standard opioid-based anesthesia.…

This early study tests whether a neuroprosthesis can restore touch sensation to the breast and reduce chronic pain in 8 women who have had both breasts removed and are undergoing reconstruction. Researchers will use tiny electrical pulses to stimulate nerves and measure what part…

This study tests whether adding amantadine or duloxetine to the standard painkiller pregabalin can prevent chronic pain after mastectomy (breast removal surgery). About 150 women undergoing this surgery will be randomly assigned to one of three drug combinations. The goal is to s…

This study compares a new care pathway called AMADeuS, where women have awake mastectomy with same-day discharge and follow-up via telemedicine, to standard hospital care. Researchers want to see if it controls pain just as well and is as safe within 30 days after surgery. About …

This study tests a new drain system (Interi) against standard drains in 20 women having implant-based breast reconstruction after mastectomy. The goal is to see if the new drain reduces complications, shortens drain time, and improves patient comfort. Participants will have both …

This study tests a 16-week video exercise program for breast cancer survivors who had surgery. The program includes live, small-group classes focused on fitness, balance, and strength. Researchers want to see if it helps improve physical function and quality of life. About 15 peo…

This study tests a device called Brijjit® to see if it can prevent thick, raised scars (hypertrophic scars) after gender-affirming double incision mastectomy. About 78 people will take part, and each person will use the device on one side of their chest while the other side serve…

This large study tests whether giving lidocaine (a common numbing medicine) through an IV during breast cancer surgery can prevent moderate to severe pain that lasts for a year or more. About 4,300 women having mastectomy or lumpectomy will be randomly assigned to receive lidocai…

This study aims to create computer programs that help surgeons design custom molds for shaping breast tissue during reconstruction after mastectomy. About 160 adults having breast reconstruction with their own tissue (DIEP or TRAM flap) will take part. The goal is to make the sur…