MASTECTOMY

This study tests if a safe green dye (indocyanine green) can help surgeons find lymph nodes that might contain cancer during a mastectomy, without needing a separate cut under the arm. About 90 women with early-stage breast cancer will receive the dye and a standard radioactive t…

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

This study compares three devices used for fat grafting in breast reconstruction after mastectomy. Researchers want to see which method leads to better fat retention and patient satisfaction. About 135 women who have had breast surgery will take part, and their results will be me…

This study tests a sticky pad called Brijjit® to see if it can prevent thick, raised scars (hypertrophic scars) after gender-affirming mastectomy (top surgery). About 78 people will take part, and each person will have the device on one side of their chest while the other side ge…

This early study tests a small device temporarily implanted in the breast during mastectomy. The device sends tiny electrical pulses to nerves to try to restore touch sensation and reduce chronic pain. Only 8 people having both breasts removed will take part, to see if the idea i…

This study aims to improve breast reconstruction after mastectomy by using custom 3D-printed molds to shape tissue into a natural breast form. Researchers will enroll 160 adults scheduled for flap-based reconstruction. The goal is to make surgery more efficient and reduce complic…

This pilot study tests a new type of surgical drain called the Interi Manifold against the standard Jackson-Pratt drain in women having implant-based breast reconstruction after mastectomy. The new drain has multiple branches and a special suction system that may remove fluid mor…

This study tests whether a new care pathway called AMADeuS, which includes awake surgery, same-day discharge, and telemedicine follow-up, is as safe and effective as standard hospital care for women having mastectomy with immediate breast reconstruction. One hundred women aged 18…

This study compares two types of nerve blocks to see which one works better for pain after mastectomy surgery. About 66 women having a mastectomy will receive one of the two blocks before surgery. The goal is to find a method that reduces pain, lowers the need for painkillers, an…

This large phase 3 trial is testing whether giving lidocaine (a numbing medicine) during and after breast cancer surgery can reduce the chance of long-term pain. About 4,300 women having mastectomy or breast-conserving surgery will receive either lidocaine or a placebo. The main …

This study tests whether adding amantadine or duloxetine to the standard painkiller pregabalin can prevent chronic pain after mastectomy. About 150 women undergoing breast cancer surgery will be randomly assigned to one of three drug combinations. The goal is to see if these add-…

This study tests a 16-week video exercise program for breast cancer survivors who have recently had mastectomy surgery. The program includes twice-weekly classes focused on aerobic fitness, balance, and strength. Researchers will track attendance and measure improvements in fitne…

This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psycho…