Brain's pain 'Off Switch' may predict who gets relief from back injections
NCT ID NCT05961800
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations before and after the injection. The goal is to understand why some people get more relief than others.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help doctors predict which patients will benefit most from nerve block injections for back pain.
What could go wrong
This is a small, early observational study with only 40 participants. It does not test a new treatment, so results may not change practice directly.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UPMC St. Margaret
RECRUITINGPittsburgh, Pennsylvania, 15215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••