A shot at smoother recovery: knee replacement pain blocks put to the test

NCT ID NCT07751653

Completed Symptom relief Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex. The goal is to find the most effective approach for easing discomfort and speeding up early recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levobupivacaine plus mepivacaine (a local anesthetic combination) injected as a single shot at the end of surgery
What this could lead to: If one block proves better, it could become the standard choice for knee replacement, helping patients recover with less pain and better movement.
What could go wrong: This is a single trial with 141 participants, so results may not apply to everyone. Blocks can cause temporary weakness or other complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA

Contacts and locations

Locations

Ospedale Galeazzi S.p.A.

Milan, Italy, 20100, Italy

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