University Of Pittsburgh

This study is testing two experimental procedures to help men regain their fertility. It is for men who froze a small piece of testicular tissue before undergoing treatments like chemotherapy that can cause permanent infertility. Researchers will either inject the stored cells ba…

This study is testing whether a supplement called nicotinamide riboside, a form of vitamin B3, can help control ulcerative colitis in children and teenagers. Researchers want to see if the supplement improves how energy-producing parts of gut cells work. The study will enroll 40 …

This study aims to find the best way to use a laser treatment called SLT to manage glaucoma and high eye pressure. It will compare whether a lower-energy laser works as well as the standard strength, and test if getting the laser treatment once a year is better than waiting until…

This study is testing a mobile phone app system designed to help people with chronic, complex conditions like spinal cord injury or cerebral palsy manage their daily care routines. The app provides reminders for tasks like catheter use and skin checks, and lets users report probl…

This study is testing a new follow-up program for adults who have just recovered from a serious episode of sudden kidney injury (AKI). The program provides extra support from a care team after leaving the hospital. Researchers want to see if this extra help keeps people healthier…

This study offers an experimental procedure to freeze testicular tissue from boys who are about to undergo treatments (like chemotherapy) that will likely make them infertile. The goal is to preserve the tissue so that, if future scientific advances allow, it could potentially be…

This study is testing whether a simple sleep improvement program can help slow down brain changes linked to Alzheimer's disease. Researchers will work with 116 older adults who have mild memory concerns or are at risk for Alzheimer's. For four weeks, participants will follow a sc…

This study is testing if a simple bedside ultrasound scan of a neck vein can help doctors better manage fluid levels in people hospitalized for worsening heart failure. The goal is to see if this more precise approach helps patients leave the hospital with the right amount of flu…

This study is testing a digital tool called MyPath that helps women with substance use disorders make informed decisions about contraception after giving birth. The tool guides women through thinking about their pregnancy goals, learning about fertility, and choosing contraceptiv…

This study is testing whether pairing pregnant survivors of intimate partner violence with specially trained doulas can help reduce abuse and improve well-being. The trial will compare doula support against standard victim services for 326 participants in the Pittsburgh area. Res…

This study is testing whether a yoga program is a practical and helpful way to reduce cravings for people in India who want to quit using tobacco. It will involve 96 men who are dependent on tobacco. They will be randomly assigned to either follow a yoga program or receive standa…

This pilot study is testing whether adding specific sleep strategies to standard parent behavior training is more helpful for families of 3-5 year olds showing early signs of ADHD and sleep problems. Therapists will deliver the programs in pediatricians' offices to make them more…

This study is testing whether it's safe to closely monitor small, slow-growing breast cancers found on mammograms in women aged 70 and older, instead of starting treatment right away. Participants will have regular imaging scans to check for any tumor growth rather than undergoin…

This study is comparing three common surgeries used to fix a shoulder that keeps dislocating, especially when there is some bone loss from the injury. It will follow 450 military personnel and civilians aged 17-50 for two years after their surgery. The goal is to see which surger…

This study is testing whether allowing a mother's blood sugar to be a bit higher during labor is safer for her newborn. It involves 218 pregnant women with diabetes who are planning a vaginal delivery. Researchers will compare a more relaxed blood sugar target to the current stri…

This study is testing whether a 10-session phone or online coaching program can help people who have both chronic pain and problems with opioid use. Researchers want to see if this program helps participants manage their pain better and stay engaged in treatment for opioid use di…

This study is testing a new computer-based training method to help people with aphasia (a language disorder after stroke) improve their word-finding ability. It will compare a new 'adaptive' training schedule to standard schedules to see if it helps people remember words better f…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study aims to preserve fertility for girls and women under 40 who face cancer treatments or other conditions that could cause permanent infertility. Participants have one ovary surgically removed and frozen for potential future use when they wish to have children. The resear…

This study aims to understand why diabetic foot ulcers often reopen after they appear to have healed. Researchers will test if a hidden type of bacterial infection, called a biofilm, causes the skin to heal with a weak barrier, making it prone to breaking open again. They will me…

This study is testing whether a smartphone app combined with a personal health coach helps people recover better from major surgery. About 1,300 adults planning abdominal or other major surgeries will be randomly assigned to use the app and coach or receive standard care. The goa…

This study is testing whether a smartphone-based coaching program can help people in rural areas better manage their high blood pressure. About 334 participants with uncontrolled blood pressure will use home monitors and receive either personalized coaching or general health info…

This study is testing whether a series of five video therapy sessions can help teens who recently attempted suicide. The program teaches healthy coping and problem-solving skills. Researchers will compare it to regular check-in calls to see which is better at reducing suicidal th…

This study is testing whether adding daily air quality information to a child's asthma action plan helps improve their asthma control and quality of life over one year. Researchers will enroll about 350 children with asthma, ages 8-17, living in Allegheny County, PA. Participants…

This study is testing a two-step approach to repair facial injuries in wounded service members and veterans. First, doctors use the patient's own fresh fat to fill facial defects. Three months later, they use previously harvested and frozen fat for a second treatment without anot…

This study is testing whether a smartphone app can help parents manage disruptive behaviors in young children. Researchers are comparing three approaches: a standalone app, the same app with coach support, and a basic control app. They aim to see which method is most effective at…

This study is testing a new pain assessment tool to see if it can predict which patients with chronic pancreatitis will get relief from standard endoscopic or surgical treatments. Researchers will enroll 150 adults with chronic pancreatitis who are already scheduled for one of th…

This study is looking at whether a special type of heart ultrasound, called strain imaging, can help identify people at risk for having another 'cryptogenic' stroke. Cryptogenic strokes happen when doctors can't find the usual cause, like an irregular heartbeat. Researchers will …

This study is testing whether a specific brand of prenatal vitamins (Perelel) works better than generic prenatal vitamins at improving nutrition and wellness during pregnancy. Researchers will enroll 600 pregnant women who will take one type of vitamin daily and have blood tests …

This study is testing whether a weekly therapy skills group is a practical way to help teenagers who are at high risk for developing psychosis. Up to 30 teens, aged 13-18, will attend a 15-week group that teaches skills to manage stress, improve self-awareness, and build social c…

This study tests whether a computer alert system can help doctors prevent opioid overdoses. A machine-learning model identifies patients at high risk, and then the system sends reminders to doctors about safer prescribing practices. The goal is to see if these alerts lead to fewe…

This study is testing a new program designed to prevent dating violence among teenagers. It works by training pediatric doctors and providing resources to parents and teens during regular check-up visits. The goal is to see if families find the program helpful and practical, and …

This study is testing a new online training program for college health and counseling center staff. The goal is to teach providers how to offer more supportive and knowledgeable care specifically for transgender and gender-diverse students. By making campus health services more w…

This study is testing which of two common methods for emptying the bladder during labor with an epidural is better at preventing urinary problems after birth. Researchers will compare leaving a catheter in place versus inserting and removing one every few hours. They want to see …

This study aims to see if helping older adults who recently lost a spouse maintain regular daily routines and stay socially connected can reduce suicidal thoughts and feelings of loneliness. It will enroll 169 people aged 65 and older who lost their partner within the last year a…

This study is testing whether a special therapy delivered by video call can help prevent bipolar disorder in teenagers who have a parent with the condition and are at high risk. Researchers will compare two different online programs—one focused on stabilizing daily routines and s…

This study is testing a digital program called Flourish, a chatbot designed to help teens who have been cyberbullied and are feeling suicidal. Researchers will compare 80 teens using the chatbot plus check-in surveys to teens only doing surveys. The goal is to see if the chatbot …

This study is testing whether a brief sleep coaching program can help depressed teenagers who don't get enough sleep or have irregular sleep schedules. Researchers will compare a two-session program using smartphone technology against basic sleep education. The study aims to see …

This study aims to see if using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. Researchers will compare these methods to the current standard of care. About 208 men scheduled for this proced…

This study is testing a new rehabilitation program designed to help people who have had a stroke get back to participating in social activities and community life. Researchers will compare the new program, which combines two types of therapy, against an existing rehab program. Ab…

This study is testing a new training program for stroke survivors who have a condition called spatial neglect, which makes it hard to pay attention to one side of their body or surroundings. The program teaches personalized strategies to help people become more aware of their neg…

This study is testing a new, targeted treatment for concussion symptoms in adults aged 50 and older. Researchers will compare this new approach to the usual standard of care. The goal is to see if the new treatment helps reduce symptoms like headaches, dizziness, and mood changes…

This study is testing different speech therapy methods to help people with aphasia (language problems after stroke) improve their ability to find words and communicate. Researchers will work with 30 stroke survivors to compare three different training approaches during picture-na…

This study is testing whether a pre-surgery program of exercise and nutrition supplements is practical and helpful for adults with esophageal cancer. Researchers want to see if this 'prehabilitation' improves patients' strength and well-being before and after their major surgery.…

This study is testing whether online therapy can help cancer patients who feel anxious or fearful about stopping their immunotherapy treatment. It will enroll 100 adults who have been treated for cancer with immunotherapy and are experiencing significant distress. The goal is to …

This study is testing a care program called CARES that helps manage the most common and distressing symptoms in cancer patients: pain, depression, and fatigue. It will enroll 1750 adults with cancer to see if this program works better than standard care in a real-world setting. T…

This study is testing a mobile health app designed to support the mental and emotional well-being of veterans with spinal cord injuries and their family caregivers. Researchers are working directly with 100 veterans and caregivers to adapt the app to their specific needs. The mai…

This study is testing a program called 'One All' that uses the sport Ultimate Frisbee to help improve mental health and resilience in young people from tribal communities in South India. Researchers want to see if this weekly sports and discussion curriculum is practical to run a…

This study is testing if starting neck-focused physical therapy earlier helps people with concussion and neck pain feel better faster. It will compare starting this therapy right away versus waiting four weeks, which is the current standard. The main goal is to see if it's practi…

This study is testing whether a smartphone app called Vira, combined with support from a health coach, can help teens with depression feel more enjoyment from daily activities. Researchers want to see if this approach can reduce feelings of depression and suicidal thoughts. Parti…

This study is testing whether a phone-based support program can help people on dialysis better manage their pain, extreme tiredness (fatigue), and depression. The program connects patients with care teams who can provide counseling or medication advice, tailored to each person's …

This study is testing whether a new smartphone app can help people better manage the side effects of chemotherapy. The app combines daily symptom check-ins with data from a Fitbit activity tracker. If the app detects concerning symptoms or health readings, it suggests when to con…

This study is testing two different talk therapies to see if they can help reduce persistent negative symptoms in people with schizophrenia. Negative symptoms include things like low motivation, reduced emotional expression, and social withdrawal. The study will enroll 90 stable …

This study is testing if a therapy app on a phone can help teens and young adults with sickle cell disease manage their chronic pain. It will see if adding one-on-one support from a peer who also has the disease makes the app more helpful. The goal is to reduce pain, lower the ne…

This study is testing a new thinking strategy training for stroke survivors who have a common attention problem called spatial neglect, where they have trouble noticing one side of their body or environment. The training teaches people to set personal goals, check their own perfo…

This study is developing and testing a behavioral skills program called MomMA for pregnant women with ADHD. The program teaches strategies to manage ADHD symptoms during pregnancy and after delivery, delivered by therapists in obstetric care settings. Researchers will assess whet…

This study is testing whether listening to music can help reduce stress and pain in children who are critically ill and on a breathing machine in the intensive care unit. Researchers will compare the effects of live music versus recorded music by measuring stress hormones and oth…

This study is testing whether using a penile traction device for three months before getting an inflatable penile implant can help men keep more of their natural length after surgery. Researchers will compare results in 48 men, half using the device and half not, to see if it lea…

This study is testing a smartphone app designed to help people recover from knee or hip replacement surgery. The app uses digital therapy techniques and coach support to help patients manage anxiety, depression, and pain. Researchers want to see if using the app can help patients…

This study aims to collect health information and biological samples from 10,000 people to better understand the genetic and environmental factors that influence pancreatic cancer risk. It includes people with pancreatic cancer, those with other pancreatic conditions, and healthy…

This study aims to find biological markers (like specific proteins) in the blood, saliva, and tissues of organ and bone marrow transplant patients. Researchers will collect samples from up to 1,200 participants over time to see if these markers can give doctors a clearer picture …

This study aims to understand the connection between the brain and the stomach. Researchers will use a safe, non-invasive brain stimulation technique on healthy volunteers to see how it affects electrical signals in the stomach. The goal is to map this brain-gut link and learn th…

This small pilot study aims to understand how different exercise schedules affect knee cartilage in people with osteoarthritis. Twenty participants with knee arthritis will follow a 12-week exercise program, with one group taking standard short breaks and another taking longer 45…

This study aims to understand how the body's heart and blood vessels react to a brief, stressful mental task and how those reactions might be connected to the health of the brain's blood vessels. Researchers will measure heart rate, blood pressure, and brain scans in 450 healthy …

This study aims to understand how a ketogenic diet (a high-fat, low-carb diet) affects the brain and mood in people with bipolar disorder. Researchers will enroll 107 adults, including people with bipolar disorder and healthy volunteers, to measure brain activity, metabolism, and…

This study is testing a new toolkit designed to help primary care doctors and nurses have better conversations with people living with dementia about their future care wishes. It will compare the toolkit to usual care across 20 clinics to see if it leads to more and higher-qualit…

This research aims to understand the genetic and molecular causes of childhood liver cancers by collecting tissue samples from patients and their families. The study will analyze DNA and tumor tissue to create a better classification system based on biology rather than appearance…

This is a long-term observational study that will follow 7,500 people with and without Multiple Sclerosis (MS) for up to 30 years. Researchers will collect health data, surveys, and biological samples to understand why MS progresses differently in different people and why treatme…

This study aims to understand if teaching mothers with depression how to encourage their child's positive emotions can improve the child's brain response to rewards. Researchers will work with 180 mothers and their 4- to 6-year-old children, randomly assigning them to either a sp…

This study aims to understand how patients recover after total knee replacement surgery. Researchers will compare recovery speed and patient experience between surgeries performed with robotic assistance and those done with traditional manual techniques. They will follow 30 patie…

This project is creating a contact list of Amish and Mennonite community members who are willing to be contacted about future medical research studies. The goal is to make it easier for researchers to find appropriate participants to study genetic health conditions that are more …

This study creates a research registry by collecting past, current, and future medical records from patients treated at the Simmons Center for Interstitial Lung Disease. The goal is to gather information from many patients to help researchers learn more about these lung diseases …

This study aims to learn more about pyruvate dehydrogenase complex deficiency (PDCD), a rare disorder that affects the body's energy production, especially in the brain. Researchers will track the health of about 150 children and adults with PDCD over time by reviewing medical re…

This study is testing a new smartphone app designed to help young adults (ages 16-24) who were diagnosed with type 2 diabetes as children. Participants will wear a continuous glucose monitor and a Fitbit for 30 days while using the app, which provides health tips. The main goal i…

This study is testing different ways to help pediatric primary care offices better use a proven program for managing child behavior problems and ADHD. Researchers will work with up to 24 doctor's offices and about 450 children and their caregivers. They are comparing methods like…

This study aims to analyze biological samples from 4,000 people with skull base tumors to understand their molecular and cellular features. The goal is to discover new patterns that could help doctors better classify tumors, predict outcomes, and inform future treatment strategie…

This study aims to create a large database and sample collection for patients with rare, inherited brain and nerve disorders. Researchers will collect detailed health information, family histories, and biological samples from up to 1,000 participants. The goal is to better unders…

This study aims to discover the genetic and immune system changes that lead to lung cancer. Researchers will analyze tissue and blood samples from 6000 people who have or are suspected to have lung cancer. The goal is to identify markers that could help detect cancer earlier and …

This study aims to understand why people with similar knee arthritis damage experience very different levels of pain, especially when walking. Researchers will recruit 300 adults with chronic knee pain to complete surveys, walking tests, knee scans, and non-invasive brain imaging…

This study aims to understand how poor sleep and disrupted body clocks in teenagers affect brain circuits related to reward and impulse control, which may increase the risk for future substance use. Researchers will observe 150 teens and test whether a sleep schedule intervention…

This study is creating a large registry of people with emphysema or COPD to help scientists better understand the disease and test future treatments. It will enroll up to 3000 participants to collect their health information, breathing test results, and a blood sample for genetic…

This study aims to understand what personal factors and physical impairments affect how well people with dizziness and balance disorders can perform daily activities. Researchers will follow 67 adults with a specific inner ear problem before and after they complete standard balan…

This study aims to understand why some teenage girls develop suicidal thoughts while others do not. Researchers will observe 100 girls, aged 12-17, who are at high risk, tracking their brain activity during social tasks, their daily text messages, and their feelings via smartphon…

This study is testing a new online tool called HART that helps dementia caregivers find health apps that match their specific needs. Researchers are recruiting 15 family caregivers to try the tool over four weeks and provide feedback on how easy it is to use. The goal is to help …

This study is testing whether a smartphone app designed to support new mothers is helpful and easy to use. Researchers want to know if using the app for 8 weeks helps mothers better understand postpartum symptoms and feel more confident in their parenting. The study involves 60 n…

This study aims to understand how children's brain function, particularly skills like memory and self-control, might be linked to their weight changes and eating patterns over time. Researchers will follow 180 children for 18 months, using brain scans and thinking tasks to see if…

This study aims to understand how over 25 rare genetic disorders that damage the brain progress over time. Researchers will follow 1,500 participants, assessing their development and brain health regularly for years. The goal is to gather detailed information to help future resea…

This study is testing a new, highly sensitive blood test to see if it can detect tiny traces of cancer DNA in men with high-risk prostate cancer before they have surgery to remove the prostate. The goal is to learn if finding this cancer DNA in the blood can help doctors better p…

This international study aims to understand the genetic causes of biliary atresia, a rare disease that causes liver failure in newborns and is the leading reason for liver transplants in children. Researchers will analyze DNA from 1,100 children with the condition and their famil…

This study aims to understand how the brain processes speech in children who stutter compared to those who don't. Researchers will use brain scans (EEG and fMRI) and language tests on 600 children to look for differences in brain activity during listening and speaking tasks. The …

This study aims to collect blood, urine, and skin samples from adults with specific skin conditions like cutaneous T-cell lymphoma, eczema, or atopic dermatitis. The purpose is to build a collection of samples for researchers to study. By analyzing these samples, scientists hope …

This study aims to understand how using cannabis and then stopping it affects sleep, the body's natural daily rhythms, and sensitivity to light. Researchers will compare 180 young adults who regularly use cannabis with those who don't, monitoring them at home and during lab visit…

This study is testing whether a new decision-making guide helps hospital doctors better manage chronic medications like those for diabetes and high blood pressure in older patients. Researchers will see if doctors using the guide feel more confident and make fewer unnecessary med…

This study aims to understand how the brain responds when different spots on the ear are gently touched. Researchers will measure brain activity in 80 healthy volunteers using a special cap with light sensors. The goal is to see if touching spots linked to the shoulder, thumb, or…

This study aims to understand how the body absorbs and processes Kaempferol, a natural substance found in many fruits and vegetables. Researchers will give Kaempferol to 120 healthy adults and measure its levels in blood and urine over time to learn about its safety and how it mo…

This study aims to find the genetic causes of undiagnosed medical conditions in Amish and Mennonite communities. Researchers will analyze the DNA of 300 participants using advanced sequencing technology. The goal is to improve diagnosis and understand how genetic changes spread i…

This study aims to understand if specific inherited traits make some people more likely to develop pulmonary fibrosis, a serious disease that causes progressive scarring of the lungs. Researchers will collect blood samples from 2,000 adults who have been diagnosed with the condit…

This study aims to understand how the amount of sleep a child gets affects their eating habits and ability to control food choices. Researchers will work with 120 children who have overweight or obesity, having them follow different sleep schedules while tracking their daily eati…

This study aims to understand how carbon dioxide levels in children's breathing affect pressure inside the eye during eye exams under anesthesia. Researchers will measure eye pressure and scan the back of the eye in 20 children aged 0-8 years who are already having scheduled eye …

This study aims to understand how fungi from the gut might move into the bloodstream and affect lung health in people living with HIV. Researchers will enroll 100 adults with HIV to measure markers of fungal movement, gut health, and lung function over three years. The goal is to…

This study aims to find genetic and biological markers that can predict when patients with idiopathic pulmonary fibrosis (IPF) might experience a rapid decline in lung function. Researchers will follow 500 patients over time, collecting blood samples, scans, and questionnaires ev…

This study aims to understand how becoming a parent affects the health of people living with cystic fibrosis (CF). Researchers will follow 146 new parents with CF for up to five years, collecting survey data on stress, mental health, and treatment routines, while also tracking th…