University Of Pittsburgh

This study tests whether a special follow-up program helps adults who had a serious kidney injury spend fewer days in the hospital over 3 months. About 2,145 participants will either get the program or usual care. The program includes extra monitoring and support to prevent furth…

This study tests whether giving children with asthma and their families daily air quality information helps them better manage the condition and avoid flare-ups. About 351 kids will receive either standard care or an enhanced asthma action plan that includes Air Quality Index (AQ…

This study looks at whether allowing slightly higher blood sugar levels in pregnant women with diabetes during labor can reduce the chance of their newborns having dangerously low blood sugar. Researchers will compare a more relaxed glucose target to the usual strict control in 2…

This study tests whether a home blood pressure monitoring program with health coaching can help rural adults better control their high blood pressure. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bl…

This study compares two standard surgical treatments for gum disease around dental implants (peri-implantitis). About 44 adults will be randomly assigned to one of two surgeries: one that reshapes the implant and one that only cleans it. Researchers will measure inflammation in t…

This study tests a program called Engaging Together for Healthy Relationships, designed to help parents and teens talk about and prevent dating violence. About 120 teens aged 12-16 and their parents will receive the program during a regular check-up at the doctor's office. Resear…

This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT), delivered via video calls, can prevent or delay bipolar disorder in teens (ages 12-18) who have a parent with bipolar disorder and are at high risk themselves. 120 participants…

This study looks at whether a specific yoga practice can help improve memory, attention, and thinking speed in people whose depression is in remission. Researchers will enroll 32 adults aged 18-60 who have had at least one depressive episode but are currently well. Participants w…

This study looks at how sensory sensitivities affect sleep and emotions in autistic children ages 6 to 10. Researchers will test a special bedtime routine designed to lower arousal levels in children who are overly sensitive to touch, sound, or other sensations. The goal is to se…

This study tests a digital health platform called Pip, paired with a live health coach, to see if it helps people recover better after abdominal surgery. About 1,300 adults scheduled for surgery will use the app and get coaching, or receive standard care. The goal is to shorten h…

This study tests a brief sleep program for depressed adolescents aged 12-18 who get too little sleep or have irregular sleep patterns. The program uses two sessions and a smartphone app to teach healthy sleep habits. Researchers will see if it is practical and helps improve sleep…

This study is for people with aphasia, a language problem that often happens after a stroke. It makes it hard to find the right words. The study will test a new way of scheduling therapy sessions to see if it helps people remember words better and use them in everyday life. About…

This study tests a collaborative care program that combines medication and/or talk therapy to help adults on hemodialysis manage pain, fatigue, and depression. About 424 participants will receive the program in a real-world setting. The goal is to see if this approach improves th…

This study tests whether a remote training program can help manual wheelchair users improve their skills, confidence, and how often they perform key movements. About 132 adults with spinal cord injuries will take part, either receiving remote feedback or being placed on a waitlis…

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR only, aromatherapy only, both, or standard car…

This study looks at how a ketogenic diet changes brain activity, metabolism, and mood in adults with bipolar disorder. Researchers will use brain scans and blood tests to measure these effects. The goal is to understand if this diet can help manage symptoms. 107 people aged 18-40…

This study tests two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on general behavior strategies, the other adds sleep-improving techniques. Researchers want to see if the sleep-focused program is more helpful and pra…

This study looks at whether cognitive-behavioral therapy can help cancer patients who feel distressed about stopping immunotherapy. About 100 adults who have had immunotherapy for cancer will take part. The goal is to reduce fear of recurrence, anxiety, and depression, and improv…

This study tests a new rehabilitation program called ACES, which combines acceptance and commitment therapy with strategy training, to help people who have had a stroke rejoin social activities. About 54 chronic stroke survivors living in the community will take part. The program…

This study tests whether a mobile app that tracks symptoms and sensor data can help people receiving chemotherapy feel better and stay connected with their care team. About 50 adults with solid tumors will use the app and a Fitbit for 90 days. The goal is to see if the app is eas…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for it. The app uses proven strategies to improve self-control and eating habits. For 16 weeks, 50 teens will use the app and share their thoughts on how hel…

This study looks at whether listening to live or recorded music can help lower stress and pain in children who are on breathing machines in the intensive care unit. About 171 children, ages 2 months to 17 years, will take part. Researchers will measure stress and pain using saliv…

This study tests a training program for college health and counseling center providers. The goal is to help them better understand and support transgender and gender diverse students, which may reduce sexual violence and heavy drinking in this group. About 100 providers will take…

This study looks at why people with similar knee arthritis can have very different levels of pain. Researchers will study walking, brain activity, and knee structure in 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tasks, knee X-rays a…

This study aims to create a new brain scan task that mimics social media to see how it affects teens with depression. About 60 teens aged 13-17 will have their brains scanned while using a custom social media app, then answer daily surveys for 16 days. Researchers will track brai…

This study explores whether the brain's electrical patterns linked to mood can be recorded on one day and then recreated on another. Researchers will measure brain activity and happiness levels in 60 adults who experience mood swings lasting at least two days. The goal is to unde…

This study is testing a mobile health app designed to help veterans with spinal cord injuries and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to adapt the app to their needs and see if it is easy to use. The goal is to…

This study tests whether a tool called MyPath helps women with substance use disorder make and stick with a birth control plan after giving birth. About 400 women will use the tool or receive standard care. The goal is to see if MyPath improves consistent use of effective contrac…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict which patients with chronic pancreatitis will get pain relief from procedures like endoscopy or surgery. About 150 adults with chronic pancreatitis will take the tes…

This study aims to uncover the genetic and molecular causes of liver cancer in children. Researchers will analyze DNA, gene activity, and other markers from up to 1,600 participants, including children with liver tumors and their biological relatives. The goal is to better classi…

This study looks at how middle-aged adults' hearts and blood vessels respond to a short, challenging mental task. Researchers will measure blood pressure, heart rate, and brain scans to see if stress reactions are linked to brain health. The goal is to understand how stress might…

This study aims to help preserve fertility in females under 40 who face infertility due to treatments like chemotherapy or radiation. Participants will have an ovary surgically removed and frozen for future use. Researchers will also study how to improve the freezing and maturati…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples to measure its levels in the body. The goal is to understand how kaempferol works …

This study aims to find genetic and immune changes that lead to lung cancer. Researchers will collect tissue samples from 6,000 people with lung cancer or suspicious lung growths. The goal is to understand how the disease starts and progresses, which could lead to better risk pre…

This study aims to find genetic and protein markers that could predict when a person with idiopathic pulmonary fibrosis (IPF) might experience a rapid decline in lung function. Researchers will collect and analyze samples from 500 adults diagnosed with IPF and compare them to cha…

This study tests whether a simple educational session can help hospital doctors feel more confident when adjusting diabetes and blood pressure medications for older adults (65+). About 150 clinicians will attend a one-time training and complete surveys before and after. Researche…

This study looks at how children's brains handle speech sounds, comparing kids who stutter with those who don't. Researchers will use brain scans (EEG and fMRI) and listening tasks to spot differences. The goal is to better understand stuttering, not to test a treatment. About 60…

This study tests whether a mobile app can help parents manage disruptive behavior in children ages 5-8. About 324 parents will be randomly assigned to use the app alone, with a coach, or a control app. The goal is to see which approach improves parenting skills and child behavior…

This study looks at whether a temporary, non-invasive brain stimulation technique called TMS can affect how healthy people respond emotionally to stress. About 55 participants will do tasks during an MRI scan, then receive both real and fake TMS on different days to compare effec…

This study looks at how changing carbon dioxide levels in the blood affects eye pressure and the thickness of a layer in the back of the eye called the choroid. Researchers will measure these changes in 20 children, ages newborn to 8, who are already having an eye exam under anes…

This study is creating a registry and biobank for people with suspected or confirmed neurogenetic disorders. Researchers will collect medical history, genetic test results, and samples over time to learn more about these conditions. The goal is to support future research, not to …

This study tests whether a weekly skills group is practical and helpful for teens aged 13-18 who are at high risk for psychosis. The group combines two proven therapies (CBT and DBT) to teach coping skills. Researchers will track attendance, satisfaction, and quality of life to s…

This study looks at whether a program called 'One All,' built around the sport Ultimate Frisbee, can help young people in tribal communities in South India become more mentally resilient. Researchers will train local facilitators and then measure changes in resilience and mental …

This study is tracking 3,500 people who have surgery for esophageal cancer to compare how well they recover after a minimally invasive procedure versus traditional open surgery. Researchers will measure quality of life, physical function, and mental health using questionnaires ov…

This study looks at how the brain responds when different spots on the ear are gently touched. Healthy volunteers wear a cap with infrared light sensors to measure brain activity during the stimulation. The goal is to understand if different ear points produce different brain sig…

This study follows 1,500 people with rare genetic brain diseases to learn how these conditions progress. Researchers will track thinking, movement, and daily living skills over time. The goal is to better understand the diseases and how treatments might affect them.

This study tests whether nicotinamide riboside, a vitamin-like supplement, is safe and practical for children with mild to moderate ulcerative colitis. About 40 participants will take the supplement and be followed for up to 12 months. The main goal is to see if the study is feas…

This study aims to understand why some chronic wounds heal and others don't by looking at genetic changes in wound tissue. Researchers will compare tissue from healing and non-healing wounds in 256 adults. The goal is to identify genetic signatures that may predict healing, which…

This study follows 146 new parents with cystic fibrosis to see how parenthood impacts their lung function and mental health over five years. Participants complete surveys about stress and depression, and researchers track their medical records. The goal is to understand how to be…

This study looks at how the daily rhythm of sleep and social activity relates to mood and suicidal thoughts in older adults who recently lost a spouse or life partner. Researchers will track 169 participants over 12 months using surveys and activity monitors. The goal is to under…

This study follows 180 children with overweight or obesity to see how their thinking skills (like memory and self-control) relate to their eating behaviors and weight changes over time. Researchers will use brain games and interviews to measure these skills. The goal is to find b…

This study aims to uncover the genetic causes of biliary atresia, a rare liver disease in newborns that often leads to liver failure and transplant. Researchers will analyze DNA from 1,100 children who have had or need a liver transplant. By finding the genes involved, they hope …

This study collects blood, urine, and skin samples from 200 adults with cutaneous T-cell lymphoma, eczema, or atopic dermatitis. The samples are stored and used for current and future research to better understand these skin conditions. Participants must be 18 or older and have a…

This study is building a research registry of up to 3,000 people with emphysema or COPD, plus a control group without lung disease. Participants provide DNA, lung function tests, and medical history to help researchers better understand the disease and identify candidates for fut…

This study looks at how cannabis use and stopping it affect sleep, daily rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users to non-users using sleep monitors, light tests, and pupil measurements. The goal is to un…

This study looks at how to improve the way pediatric primary care clinics handle children's behavior problems and ADHD. Researchers will test different strategies to help clinic teams work together more effectively. About 450 healthcare providers and families will take part. The …

This study looks at whether it is safe for women aged 70 and older with very small, screen-detected breast cancers to skip immediate treatment and instead have regular imaging to monitor the tumor. Researchers will track how many participants' tumors grow within 12 months. The go…

This study collects and freezes testicular tissue from boys who are not yet producing sperm and are at risk of infertility due to cancer or autoimmune disease treatments. The tissue is stored in a lab for possible future use to help them have biological children once experimental…

This study is looking at proteins in the body of people who have had an organ or bone marrow transplant. The goal is to better understand how anti-rejection drugs work and why some people reject their transplant while others do not. About 1,200 transplant patients of all ages wil…

This study looks at whether improving deep sleep can help protect the brain in older adults at risk for Alzheimer's disease. Researchers will ask 116 people aged 65-85 with mild sleep issues to spend less time in bed to naturally deepen their sleep. They will measure changes in m…