University Of Pittsburgh

This study looks at whether strength training (like weightlifting) can help adults taking GLP-1 obesity drugs keep their muscle and improve mental health. Forty inactive adults with obesity will either do supervised resistance exercise twice a week for 3 months or just take the m…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study compares three common surgeries for people with shoulder instability and moderate bone loss (10-20%). The goal is to see which procedure leads to better function, faster return to work or sports, and fewer repeat dislocations. The trial will follow 450 military and civ…

This study tests a program called iCHART, designed to help teens aged 12-18 who have depression or suicidal thoughts. The program connects them to mental health care and safety planning. Researchers hope it will reduce suicide-related events by 50% compared to usual care.

This study looks at two standard surgeries for peri-implantitis, a gum infection around dental implants. About 44 adults will get either resective surgery with implantoplasty (smoothing the implant) or with simple cleaning. Researchers will measure inflammation in blood, gum tiss…

This study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant the patient's own frozen testicular tissue back into them. The goal is to see if it is safe and can restart sperm production.

This study tests whether using a simple bedside ultrasound to measure fluid levels can help doctors give the right amount of medication to heart failure patients. The goal is to reduce hospital readmissions within 30 days and prevent kidney damage. About 588 adults hospitalized w…

This study tests whether Perelel trimester-specific prenatal supplements improve nutritional markers in pregnant women with food insecurity better than generic prenatal vitamins. Six hundred participants will take either supplement daily throughout pregnancy and provide blood sam…

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can help children with mild to moderate ulcerative colitis. About 40 kids will take either the supplement or a placebo for 6 to 12 months, alongside their usual treatment. The main goa…

This study tests a home blood pressure monitoring program paired with health education and coaching for rural adults with uncontrolled hypertension. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bloo…

This study tests a two-step procedure to repair facial defects from injuries in veterans. First, doctors take fat from the patient and use it to fill the defect. Extra fat is frozen and used in a second procedure three months later, avoiding another fat harvest. The goal is to se…

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This study tests whether a special follow-up program led by nurses and kidney specialists helps people recover better after a serious kidney injury. About 2,145 adults who had moderate to severe kidney injury in the hospital will be randomly assigned to either the program or usua…

This pilot study tests a program called Engaging Together for Healthy Relationships, designed to help caregivers and teens talk about and prevent dating violence. The program is delivered during regular pediatric check-ups. Researchers will enroll about 120 teens aged 12-16 and t…

This study tests a prevention program in college health and counseling centers to reduce alcohol-related sexual violence and heavy drinking among at-risk students. About 2,400 undergraduate students aged 18-24 who visit these centers will take part. The program includes provider …

This study tests whether a program that helps neighbors work together and build trust can reduce violence in their community. About 4,600 teens and adults in selected Pittsburgh neighborhoods will take part. Researchers will compare changes in violence rates and community cohesio…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study tests whether yoga can lower tobacco cravings in men aged 18-65 who want to quit. 96 participants will either do low-impact yoga or receive standard quitting advice. Researchers will measure cravings and relapse over three months to see if yoga is a helpful addition.

This study is testing a smartphone app called Vira, combined with health coaching, to help teens aged 12-18 who are dealing with depression and loss of interest in activities. The goal is to see if this approach can increase enjoyment and reduce the risk of suicide. Participants …

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful. About 20 adults scheduled for surgery will either receive the program or standard care. Researchers will track how many people stick with the progra…

This study looks at how stress and sleep affect the mood and brain health of people caring for a loved one with dementia. About 120 caregivers aged 55 and older will receive one of two types of talk therapy. Researchers will track their mood, activity, and brain scans to see whic…

This study compares two behavioral approaches to see which works better for improving mood, sleep, and reducing suicide risk in adults aged 55 and older with depression. Participants will complete interviews, questionnaires, and wear a sleep tracker for 8 weeks. The goal is to fi…

This study tests a training program for stroke survivors who have trouble paying attention to one side of their world, a condition called spatial neglect. The training teaches mental strategies to improve awareness and daily functioning. Researchers will enroll 45 people living i…

This study tests a behavioral program called MomMA for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms and related mood issues during pregnancy and after birth. Researchers will compare it to usual care in 80 participants to see if it is acceptable an…

This study looks at how sensory sensitivity affects sleep and emotions in autistic children ages 6-10. Researchers will test a simple bedtime routine called Power Down, where caregivers give their child a gentle massage to help them relax before sleep. The goal is to see if this …

This study tests whether pairing pregnant survivors of intimate partner violence (IPV) with a trained doula can reduce abuse and coercion compared to standard advocacy. Researchers will enroll 250 participants in the Pittsburgh area and track experiences of physical, sexual, emot…

This study compares two therapy programs designed to help autistic people manage their emotions. One program (EASE) was created specifically for autistic individuals, while the other (Unified Protocol) is a general therapy. Researchers want to see which one works better in real-w…

This study tests three different naming treatments for people with aphasia, a language disorder often caused by stroke. The goal is to see which approach best helps participants remember words and use them in daily life. Thirty adults with chronic aphasia will practice naming pic…

This study tests two short support programs for stem cell transplant patients and their family caregivers. The goal is to help them work together to manage medications, infections, and daily tasks after leaving the hospital. Researchers will see if these programs improve how well…

This study looks at whether a specific yoga practice can help improve memory, attention, and mental flexibility in people whose depression is in remission. Researchers will compare a group doing yoga plus their usual care to a group receiving usual care alone. The goal is to see …

This study tests a brief behavioral sleep program for depressed teens aged 12-18 who sleep less than 7 hours or have irregular sleep. The program uses two sessions and smartphone tools to help teens set sleep goals. Researchers will compare it to a simple sleep education session …

This study tests whether personalized behavioral treatments can help adults aged 50 and older recover from a mild concussion. Participants receive either standard care or a treatment plan tailored to their specific symptoms, such as anxiety, dizziness, or headache. The goal is to…

This study tests whether giving children with asthma and their families Air Quality Index (AQI) information helps improve asthma control. 351 children will receive either EPA or commercial AQI education plus an asthma action plan, or standard care. Over 48 weeks, researchers will…

This study tests whether a weekly skills group is practical and helpful for teens aged 13-18 who are at clinical high risk for psychosis. The group combines two types of therapy to teach coping and social skills. Researchers will track attendance, satisfaction, and quality of lif…

This study is testing whether a mobile app that combines daily symptom reports with Fitbit data can help cancer patients better manage side effects during chemotherapy. Fifty adults with solid tumors will use the app for 90 days, receiving tips for mild symptoms and alerts to con…

This study is testing a program called TĀCcare 2.0, which combines medication and talk therapy to help people on hemodialysis manage pain, fatigue, and depression. About 424 adults who have been on dialysis for at least 3 months will take part. The goal is to see if this team-bas…

This study looks at whether listening to live or recorded music can help lower stress and pain in children who are on breathing machines in the intensive care unit. About 171 children, ages 2 months to 17 years, will take part. Researchers will measure stress and pain using saliv…

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR, aromatherapy, both, or standard care. The goa…

This study tests a tool called HART that helps caregivers of people with Alzheimer's or related dementias find health apps suited to their needs. Fifteen family caregivers will use the tool for four weeks and provide feedback on how easy it is to use and whether it improves their…

This study is testing a new behavioral program for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms during pregnancy and after the baby is born. Ten participants will work with a therapist in an OB care setting. The goal is to see if the program is acc…

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without a peer health coach, can reduce pain and opioid use in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants use an app to track pain and mood,…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

This study tests whether adjusting the timing of speech therapy sessions can help people with aphasia (trouble speaking after a stroke) remember words better and use them in daily life. About 32 adults with chronic aphasia will practice naming pictures using a computer program th…

This study tests whether cognitive behavioral therapy (CBT) can reduce fear, anxiety, and depression in cancer patients who are distressed about stopping immunotherapy. One hundred adults who have finished immunotherapy will receive CBT sessions. The goal is to see if this talkin…

This study tests whether using a smartphone app called Pip Care, along with a live health coach, can help people recover better after abdominal surgery. About 1,300 adults having planned inpatient surgery will either use the app plus coaching or receive standard care. The main go…

This study tests a new rehab program called ACES, which combines acceptance and commitment therapy with strategy training, to help chronic stroke survivors take part in social activities again. Fifty-four adults who had a stroke at least six months ago and live in the community w…

This study tests a program called CARES that provides cancer patients with integrated screening and stepped care for symptoms like pain and depression. About 1,750 adults with cancer will be randomly assigned to CARES or standard care. The goal is to see if CARES improves quality…

This study tests whether using a penile traction device (RestoreX) for 3 months before getting a penile implant can increase the length of the implant and improve patient satisfaction. About 48 men with erectile dysfunction will be randomly assigned to use the device or not. The …

This study tests whether a web-based decision aid helps people considering vasectomy make more informed choices. About 750 participants will use the tool or standard information and then answer surveys about their knowledge and decision-making. The goal is to see if the aid reduc…

This study uses fMRI and EEG to understand how brain areas that plan movement interact with those that process sound during speech. Researchers will compare healthy adults and people who have had a cerebellar stroke. The goal is to learn how the brain adjusts hearing during speak…

This study looks at why people with obesity often regain weight after losing it through a behavioral weight loss program. About 205 adults aged 25-59 will first lose at least 7% of their body weight, then be followed for a year to track how much weight they regain. The goal is to…

This study is building a library of audio stories from patients and caregivers. Researchers will record personal experiences to better understand what it's like to live with or care for someone with a health condition. The goal is to create a searchable archive that other researc…

This pilot study explores whether eating high-fermented foods (like yogurt and kimchi) followed by high-fiber supplements can change the gut microbiome and improve immune response in people with melanoma or lung cancer who are receiving standard immunotherapy. Researchers will tr…

This study looks at how the liver's natural size changes throughout the day and after eating can impact the planning of a precise type of radiation therapy (SBRT) for upper abdominal cancers. Researchers will measure liver volume differences in 17 participants to see if these var…

This study looks at how a mother's emotions and history of suicidal behavior might influence her child's risk of suicidal thoughts or actions. About 150 mother-child pairs (children aged 9-11) will be randomly assigned to either a 6-month DBT skills training program or standard c…

This pilot study tests a training program for college health center providers to improve their care for trans and gender diverse (TGD) students, who face higher risks of sexual violence and heavy drinking. The training includes two parts: one on sexual violence prevention and ano…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This study looks at whether taking a nap during a night shift can improve blood pressure and alertness in healthcare and public safety workers. Researchers will compare naps lasting 0, 15, 30, 45, or 60 minutes taken at 2:00 AM. The goal is to find the nap length that best balanc…

This study from the University of Pittsburgh is testing whether fasting one day per week for 12 weeks changes how the body processes fats and maintains bone health. Researchers are enrolling 90 normal-weight or overweight adults aged 21-45 who have a family history of type 2 diab…

This study collects tissue and fluid samples from 300 adults with breast lumps or breast cancer to find unique protein patterns. Researchers compare samples from cancerous and healthy tissue to develop better blood tests for diagnosis and prognosis. Participants must be 18 or old…

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This study aims to create a more realistic brain-scan task that mimics social media interactions, like getting likes or comments. Researchers will scan the brains of 60 teens with depressive symptoms while they receive virtual peer feedback. The goal is to see how brain activity …

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

Researchers at the University of Pittsburgh are testing whether a short, non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can alter emotional and physical responses to stress. Fifty-five healthy adults will receive both real and sham stimu…

This study looks at whether a blood test can find tiny bits of tumor DNA (ctDNA) in people with early-stage triple-negative breast cancer. Researchers will collect blood samples before and during treatment to see if the test can help predict if the cancer might come back. About 7…

This study tests different ways to help teenagers and young adults with type 2 diabetes address social needs like food or housing. About 104 teens and their caregivers will try either tailored resource lists or a universal empowerment approach. The goal is to see which method is …

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study compares how patients recover and feel after two types of surgery for esophageal cancer: minimally invasive (smaller cuts) versus open surgery. Researchers will track quality of life, pain, and daily function for up to three years in 3,500 participants. The goal is to …

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study is collecting medical history, blood, and tissue samples from 7,000 people with esophageal disorders like GERD or Barrett's esophagus. Researchers hope to find genetic or protein markers that signal a higher risk of developing esophageal cancer. The goal is to enable e…

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

This study tests whether a special training toolkit helps doctors and nurses have better conversations about future medical care with people living with Alzheimer's or related dementias. The researchers will compare clinics that use the toolkit to those that continue usual care, …

This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep a…

This study tests a digital program called Flourish (formerly imHere4U) designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will be randomly assigned to either use Flourish plus fill out questionnaires or just fill out questionn…

This study tests if an electronic program that teaches healthy coping and problem-solving skills can reduce suicide risk in teens who have recently attempted suicide. Researchers will compare teens who use the program to those who receive standard care. The goal is to see if the …

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study looks at how animal-based and plant-based proteins change metabolism and immune signals in healthy adults. Twenty participants will drink three different protein smoothies on separate visits and give blood samples. Researchers want to see if adding leucine to plant pro…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples over a short period. The goal is to understand how the body handles this compound,…

This study looks at how biofilm infections in diabetic foot ulcers affect skin healing and whether poor skin barrier function leads to the wound coming back. Researchers will measure water loss through healed skin to check barrier strength. The goal is to understand the link betw…

This study uses advanced genetic testing (whole exome and whole genome sequencing) to find the genetic causes of undiagnosed diseases in people of Amish or Mennonite descent. Researchers will analyze DNA from 300 participants to identify disease-causing gene mutations and study h…

This study aims to preserve fertility for up to 500 female patients under 40 who are at risk of infertility due to cancer, autoimmune diseases, or their treatments. Participants will have an ovary surgically removed and frozen for potential future use. Researchers will also study…

This study is creating a large database and biobank for people with suspected or confirmed neurogenetic disorders. Researchers will collect medical history, genetic test results, and samples over time to learn more about these conditions. The goal is to support future research th…

This study tests whether brain activity patterns recorded on a good or bad mood day can be triggered again later. Researchers will measure brain waves and happiness levels in 60 adults who experience mood swings lasting at least two days. The goal is to understand if mood-related…

This pilot study is testing a new smartphone app called Healthmine that pairs data from a continuous glucose monitor and a Fitbit. Thirty young adults aged 16-24 who were diagnosed with type 2 diabetes before age 18 will use the app for 30 days. The goal is to see if the app is e…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study looks at how gentle touch on different parts of the ear affects brain activity in 80 healthy adults. Participants wear a cap with infrared sensors to measure brain signals while a plastic filament gently stimulates points on both ears. The goal is to see if different e…

This study is collecting information from children and adults with pyruvate dehydrogenase complex deficiency (PDCD), a rare genetic disorder that affects energy production in cells. Researchers will review medical records, ask participants about their health history, and perform …

This study looks at how teenage girls at high risk for suicidal thoughts react to social threats, like feeling left out. Researchers want to see if these reactions affect how connected they feel to others day-to-day and their risk for suicidal thoughts over time. One hundred girl…

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to tre…

This study looks at how to help pediatric primary care offices better use a proven program called DOCC for children with behavior problems and ADHD. The program involves counseling and support for families. Researchers will compare different strategies to help clinic teams adopt …

This study follows 1500 people with rare genetic brain disorders to learn how these diseases progress. Researchers measure thinking, movement, and daily living skills over time, and also look at brain scans and body fluids. The goal is to better understand the diseases and how tr…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study creates a registry of Amish and Mennonite people who want to take part in future medical research. It does not test any treatment or drug. Instead, it builds a list of volunteers so researchers can contact them about studies that match their health and family history. …

This study tests whether teaching mothers with depression to encourage positive emotions in their young children (ages 4-6) can increase the child's brain response to rewards. 180 mother-child pairs will be randomly assigned to either a parent-coaching program or general parentin…

This study looks at how changing carbon dioxide (CO2) levels in the blood affects eye pressure and the thickness of a layer behind the retina (choroid) in children. Researchers will adjust breathing during eye exams under anesthesia for 20 children aged newborn to 8 years. The go…

This study aims to find the best way to record electrical signals from the stomach to the brain using a non-invasive technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings in 155 healthy adults to see what works best. The go…

This study looks at whether a heart ultrasound technique called left atrial strain can predict stroke risk in people who had a stroke with no known cause. Researchers will measure heart function in 900 adults and track who has another stroke. The goal is to find a safe, low-cost …

This study collects blood, urine, and skin samples from 200 adults with cutaneous T-cell lymphoma, eczema, or atopic dermatitis. The samples are stored and used for current and future research, such as studying proteins in the blood and tissue. Participants must have one of these…

This study follows 7,500 people with multiple sclerosis and healthy volunteers over 30 years to learn why the disease affects people differently and why some respond better to treatments. Researchers will collect health data and track changes over time to help create more persona…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study is testing whether a smartphone app can help new mothers in Pennsylvania with postpartum education, symptom tracking, and parenting support. Sixty women who recently gave birth will use the app for 8 weeks and answer surveys about how easy it is to use and whether it m…

This study tests whether spending less time in bed for four weeks can deepen sleep and boost memory in adults aged 65-85 who have poor sleep and are at risk for Alzheimer's. Researchers will measure brain activity, memory, and blood markers. The goal is to see if a simple behavio…

Researchers at the University of Pittsburgh are studying how a ketogenic diet—a high-fat, low-carb eating plan—affects brain activity, metabolism, and mood in adults with bipolar disorder. The study will compare people with bipolar disorder who follow either a ketogenic or non-ke…

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study is testing whether it is safe for women aged 70 and older with small, screen-detected, ER+/HER2- breast cancers to simply monitor the tumor with regular ultrasounds instead of undergoing immediate treatment like surgery or radiation. The main goal is to see how many tu…

This study is testing a program called 'One All' that uses the sport Ultimate Frisbee to help young people in tribal communities in South India build mental health resilience. Researchers will train local young adults as facilitators to run the three-year curriculum. They will me…

This study aims to collect medical history, family history, and blood or urine samples from 10,000 people with or at risk for pancreatic cancer. Researchers will use this information to look for genetic and environmental factors linked to the disease. Participants may also be ask…

This study looks at how the 24-hour patterns of sleep and social activity relate to mood and suicidal thoughts in older adults who recently lost a spouse or life partner. Researchers will track 169 participants for 12 months using surveys and activity monitors. The goal is to und…

This study collects blood samples from 2,000 adults with pulmonary fibrosis to find genetic traits that may explain why they developed the disease and why scarring patterns differ. Participants must be 18 or older and have a confirmed diagnosis. The goal is to better understand t…

This study follows 146 people with cystic fibrosis who recently became first-time parents. Researchers will track their lung function, mental health, and stress levels over five years using surveys and medical records. The goal is to understand how parenthood affects their health…

This study is collecting blood and tissue samples from 500 people with idiopathic pulmonary fibrosis to find genetic and protein markers that might predict rapid lung function decline. Researchers will compare these markers with changes in symptoms over time. The goal is to bette…

This study is collecting blood samples from 24 men with high-risk localized prostate cancer before they have their prostate removed. Researchers will use a highly sensitive test to look for tiny bits of tumor DNA floating in the blood. The goal is to see if this DNA can help pred…

This study is creating a registry of medical information from people with interstitial lung disease (ILD). Researchers will collect past, current, and future health records from up to 5,000 adults treated at the UPMC Simmons Center. The goal is to build a database that can be use…

This study aims to find genetic and immune changes that help lung cancer start and grow. Researchers will collect tissue samples from 6,000 people with lung cancer or suspicious lung masses. The goal is to better understand the disease, not to test a new treatment.

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

This study is creating a registry of people with emphysema to collect DNA, lung function tests, and medical information. Researchers hope to use this data to better understand the disease and develop new therapies. The registry will also help identify volunteers for future resear…

This study collects and analyzes tumor samples from 4000 people with skull base tumors. Researchers will study the genetic and molecular makeup of these tumors to learn how they form and resist treatment. The goal is to identify new targets for future therapies.

This study looks at how children who stutter process speech sounds compared to children who do not stutter. Researchers will use hearing tests, brain wave recordings (EEG), and brain scans (fMRI) to measure brain activity. The goal is to understand the differences in speech proce…

This study is collecting genetic and molecular data from up to 1,600 children with liver cancer and their families. Researchers will analyze DNA, gene activity, and immune cells to better understand what drives these rare tumors. The goal is to improve how these cancers are class…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study is looking at proteins in the blood and tissues of people who have received an organ or bone marrow transplant. The goal is to learn more about how anti-rejection drugs work and why some people reject their transplant while others do not. Researchers will follow 1,200 …

This study aims to uncover the genetic and developmental causes of biliary atresia, a rare condition that leads to liver failure in newborns and accounts for half of all childhood liver transplants worldwide. Researchers will analyze DNA from 1,100 children who have had or need a…