Weightlifting may save muscle while on Weight-Loss drugs

NCT ID NCT07652333

Recruiting now Disease control Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether strength training (like weightlifting) can help adults taking GLP-1 obesity drugs keep their muscle and improve mental health. Forty inactive adults with obesity will either do supervised resistance exercise twice a week for 3 months or just take the medication. Researchers will measure changes in body composition, muscle strength, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GLP-1 receptor agonists (obesity medication) and resistance exercise (weightlifting)
What this could lead to: If it works, this could show that adding strength training to obesity medication helps preserve muscle and boost quality of life.
What could go wrong: This is a small, early pilot study with only 40 people. Results may not apply to everyone, and the exercise program may be hard to stick with.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE COMPOSITION OBESITY QUALITY OF LIFE (QOL)

Contacts and locations

Locations

Physical Activity Research Center, University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15219, United States

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