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Scientists aim to find the perfect dose of resistance exercise for heart health

NCT ID NCT06619444

Prevention Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study looks at how different amounts of resistance exercise (like weight lifting) affect heart health in overweight, inactive adults. Participants are split into groups that do aerobic exercise alone or aerobic plus varying durations of resistance training. The goal is to determine the minimum, optimal, and maximum effective dose of resistance exercise for preventing cardiovascular disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
resistance exercise
What this could lead to
If successful, this could provide clear guidelines on how much resistance exercise is needed to prevent heart disease, helping millions improve their health.
What could go wrong
This is a behavioral study, not a drug trial, so results depend on participant adherence. The findings may not apply to people who are already active or normal weight.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-Smoker * Overweight or Obese: Body Mass Index 25-43 kg/m2 * Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months * Walking \<7,000 steps/day at baseline * Capable of performing the required exercise training Exclusion Criteria: Absolute * Unstable coronary heart disease or heart failure * Uncontrolled arrhythmias or severe aortic stenosis * Acute myocarditis, endocarditis, or pericarditis * Cancer, requiring treatment in the past 5 years * Autoimmune diseases, affecting immune system * Plans to be away ≥4 weeks in the next 1 year * Pregnancy/anticipated pregnancy during the study * Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training * Uncontrolled Diabetes (HbA1c ≥8.0), * Hypertensive Blood Pressure ≥160 mm Hg Systolic and/or 100 mm Hg Diastolic, Relative (should consult a physician) * Major risk factors for coronary heart disease * Uncontrolled diabetes or musculoskeletal limitations

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Conditions

The condition(s) this trial relates to.

Motor Activity cardiovascular disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular risk

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Physical Activity Research Center (PARC)

    RECRUITING

    Pittsburgh, Pennsylvania, 15219, United States

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