Can a diabetes drug shield the hearts of people with schizophrenia?
NCT ID NCT07770282
First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time
Summary
This trial tests whether adding semaglutide—a medication used for diabetes and weight management—to standard antipsychotic treatment can lower the 10-year risk of heart attack and stroke in people with schizophrenia who also have metabolic syndrome. The study will measure changes in cardiovascular risk scores, insulin resistance, cholesterol, and weight over 24 weeks. It aims to find a safe and effective way to address the high rates of heart disease in this population.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- semaglutide (oral tablet) added to usual antipsychotic treatment
- What this could lead to
- If effective, this could offer a new way to reduce heart attack and stroke risk in people with schizophrenia who have metabolic syndrome, potentially improving overall health and longevity.
- What could go wrong
- This is a phase 3 trial, but results may not be conclusive or may not apply to everyone. Semaglutide can cause gastrointestinal side effects, and its psychiatric safety needs confirmation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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