Can a smartphone app and a coach help young sickle cell patients hurt less?
NCT ID NCT06374238
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without a peer health coach, can reduce pain and opioid use in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants use an app to track pain and mood, and some get weekly calls from a trained peer coach. The goal is to see if these tools improve pain intensity and daily functioning compared to usual care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
digital cognitive behavioral therapy (CBT) with or without a peer health coach
What this could lead to
If it works, this could offer a practical, non-drug way to manage chronic pain and reduce opioid use for young people with sickle cell disease.
What could go wrong
This is a behavioral intervention study, not a drug trial, so benefits may be modest. Results depend on participants sticking with the app and coaching, which can be challenging.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PAIN are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Ann and Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30345, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Connecticut Children's Medical Center
RECRUITINGHartford, Connecticut, 06106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
East Carolina University Health Medical Center
RECRUITINGGreenville, North Carolina, 27834, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Rutgers New Jersey Medical School
RECRUITINGNewark, New Jersey, 07103, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
The Regents of the University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109-1079, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
UCLA Mattel Children's Hospital Ronald Reagan Hospital
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
UPMC Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
UPMC University of Pittsburgh Classical Hematology Adult Clinic
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of South Alabama Medical Center
RECRUITINGMobile, Alabama, 36617, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
-
Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Wake Forest Baptist Hospital
RECRUITINGDurham, North Carolina, 27106, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Weil Cornell Medical College
RECRUITINGNew York, New York, 10065, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••