Could watching and waiting replace surgery for some breast cancers?
NCT ID NCT07262138
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether it is safe for women aged 70 and older with small, screen-detected, ER+/HER2- breast cancers to simply monitor the tumor with regular ultrasounds instead of undergoing immediate treatment like surgery or radiation. The main goal is to see how many tumors grow within 12 months. The study involves 50 participants and uses serial imaging to track any changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could show that active monitoring is a safe option for older women with small, low-risk breast cancers, potentially avoiding unnecessary treatments.
- What could go wrong
- This is a very early, small study (50 participants) with no control group. It only tracks tumors for 12 months, so long-term safety is unknown. Some tumors may grow during monitoring.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States