University Of Pittsburgh

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This trial tests whether repairing the facial vein during neck dissection can prevent lymphedema—painful swelling—in adults with head and neck cancer. Participants receive standard cancer surgery plus, if needed, immediate reconstruction of the facial vein. Researchers then compa…

This pilot study will test whether a multi-domain program—including psychological support, diet changes, targeted therapy, and parent counseling—can improve thinking skills and behavior in 50 children (ages 6-16) with Type-1 diabetes who have hypoglycemia unawareness (not feeling…

This study looks at whether adding a mobile app to a nurse-led counseling program helps men with alcohol use disorder stay sober longer. About 74 men aged 18-59 who own an Android phone will take part. The goal is to see if the app reduces relapse rates over three months compared…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This trial tests whether brief behavioral sleep therapy and mindfulness, alone or combined, can reduce how often older women wake up at night to urinate. Women aged 65 and older with frequent nocturia and poor sleep will be randomly assigned to one of four groups: sleep therapy, …

This study tests whether placing a thin layer of the patient's own fat under a skin graft on the penis leads to better healing, feel, and function. Twenty-four men scheduled for reconstructive penile surgery will be randomly assigned to receive either the standard skin graft alon…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests whether teaching older adults (60+) about healthy sleep habits can reduce insomnia. Over 6 weeks, participants attend two face-to-face sessions and get regular phone follow-ups. The goal is to see if this behavioral approach improves sleep quality without medicat…

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to person…

This pilot study explores whether a structured approach called shared decision-making can be successfully implemented in a methadone treatment program. Shared decision-making involves clients and healthcare professionals working together to make treatment choices. The study will …

This pilot study tests whether a daily fermented papaya supplement can improve skin barrier function in healthy adults aged 50 to 75. The main focus is on reducing water loss from the skin on the face, arms, and hands, measured with a non-invasive device. Participants take the su…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder stick to their medication routine. Researchers will enroll 50 adults who are in remission and see if using the app is practical and well-liked. The goal is t…

This study will test a new care pathway for rehabilitation after total knee replacement. The pathway includes a patient education booklet and optimized scheduling of physical therapy. Researchers want to see if this approach improves recovery and reduces differences based on race…

This study will enroll 220 adults in India who have had high suicidal thoughts or a recent suicide attempt. Researchers will use questionnaires and thinking tests to measure executive function, metacognition (awareness of one's own thoughts), and stigma around suicide. The goal i…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This observational study at the University of Pittsburgh will enroll 24 kidney transplant recipients to deeply analyze why some rejections are stubborn. Researchers will use biopsies and blood samples to map immune cells and genetic changes. The goal is to better predict and unde…