University Of Pittsburgh

This study looks at different ways to fix a torn ACL in young, active people who are at high risk of re-injury. About 1,200 participants will get one of two types of tendon grafts, with or without an extra stabilizing procedure. The goal is to find the best approach to prevent th…

This study tests whether giving time- and event-based cues (like alarms or daily routines) can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 adults aged 18-60 with these conditions will be split into two groups: one gets the cue…

This study looks at whether a team-based care model can help pregnant and postpartum women with opioid use disorder start and stay on medication, reduce overdoses, and keep their children out of foster care. About 1,350 women from three low-resource clinics in Pennsylvania will t…

This study planned to test a combination of two drugs, golcadomide and nivolumab, in adults with non-Hodgkin lymphoma that continued to grow or came back after CAR-T cell therapy. The goal was to find the safest dose and see if the combo could shrink tumors. However, the trial wa…

This study looks at using radiofrequency ablation (RFA), a treatment that uses heat to destroy tumors, for people with lung cancer or tumors that have spread to the lungs. It includes 72 patients who cannot have surgery due to other health issues or who choose not to. The goal is…

This study tests a non-surgical method to retrieve sperm from men with a condition called azoospermia, where no sperm is present in the ejaculate. Using ultrasound guidance, doctors flush and aspirate the rete testis to collect sperm. The goal is to provide a fertility option wit…

This Phase 3 study tests whether adding automated red blood cell exchange to usual care reduces hospital visits and deaths in adults with sickle cell disease who are at high risk. About 173 participants will be randomly assigned to receive either standard care alone or standard c…

This study tests whether adding computer-based cognitive training to standard esketamine treatment can improve depression symptoms. Researchers will enroll 40 adults aged 18-80 who are already receiving esketamine at the University of Pittsburgh clinic. The goal is to see if this…

This study looks at whether having surgery sooner or later, and starting rehab earlier or later, helps people with severe knee injuries recover faster. It includes 690 military members and civilians aged 16 to 55. The goal is to find the best timing to help people return to work,…

This pilot study tests whether adding extra support—like pre-visit calls and follow-ups—to regular telemedicine visits helps adults with complex type 2 diabetes. About 50 participants who use insulin and have other health conditions will be followed for 6 months. The goal is to s…

This study tests two types of talk therapy—Cognitive Enhancement Therapy and Enriched Supportive Therapy—to see if they can reduce persistent negative symptoms in people with schizophrenia. Negative symptoms include things like lack of motivation, reduced emotional expression, an…

This study tests whether a 12-week Pain Self-Management (PSM) program helps people with chronic pain and opioid misuse or opioid use disorder (OUD) manage pain better and stay engaged in their OUD treatment. About 204 adults from primary care clinics will either take part in PSM …

This study aimed to see if a special computer-based brain training program could help people with long-term dizziness and balance issues (chronic vestibular disorders). The training focused on spatial skills and was meant to be used alongside standard physical therapy. However, t…

This study is testing a family-focused therapy for parents and children (ages 8-14) who have lost a parent to suicide at least a year ago and are struggling with prolonged grief. The therapy is adapted from an adult grief treatment and includes sessions with both the parent and c…

This study tests a mobile cognitive-behavioral therapy (CBT) program called MAAT to help breast cancer survivors with memory and concentration problems after chemotherapy. About 220 survivors who finished chemo 1-5 years ago and still have cognitive issues will be randomly assign…

This study tests two types of talk therapy for teens with anorexia nervosa, delivered at home instead of a clinic. About 50 teens and their families will take part to see if home-based treatment helps with weight, eating habits, and family skills. The goal is to make treatment ea…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk than others. Researchers will test a community-based behavior change program in 800 high-risk participants to see if it works better than usual care. The…

This study tests a program called PIC-TRFS to help patients aged 50 and older recover after a stay in the intensive care unit (ICU). The program includes health management, rehabilitation, social support, and care coordination through telehealth check-ins. Researchers want to see…

This study aims to find the best way to get more veterans tested for colon and liver cancer. Researchers will compare two approaches: directly contacting people who need screening, or helping doctors fix delays in the testing process. Over 30,000 veterans and their healthcare pro…

This study looks at ways to help people in rural Pennsylvania become more physically active. It includes 880 adults who are overweight, have type 2 diabetes, or are not active. Researchers will track activity levels using questionnaires and wearable devices to see what works best…

This study looks at whether a simple blood test can help track cancer recurrence in people with stage III colorectal cancer. Researchers will measure circulating tumor DNA (ctDNA) in 137 participants over time. The goal is to see if ctDNA levels can predict if the cancer comes ba…

This study aims to understand the challenges and opportunities in improving mental health support in schools in Chennai, India. Researchers will interview students aged 12-18, teachers, parents, and school staff to learn about the current school environment and how to implement e…

This study looks at different methods to help doctors and nurses remove breathing tubes from patients in intensive care. It compares online training, team-based education, and step-by-step care plans to see which works best. The goal is to reduce deaths and improve recovery for p…

This study looks at how the relationship between a caregiver and their family coach can help prevent child maltreatment. Researchers will study 612 families in a prevention program to see if a strong connection with the coach leads to better protective factors like resilience and…

This study looks at whether a pharmacist's review that includes a person's genetic test results can lead to better medication outcomes and lower healthcare costs. About 600 employees from Pitt/UPMC who already had genetic testing will take part. Half will get a medication review …

This study tests a program called Nae Disha for Life, designed to reduce suicide thoughts and build resilience in young people aged 12-17 in rural India. About 272 students from middle schools in Madhya Pradesh will take part. The goal is to see if the program is practical and ef…

This study looks at whether a machine-learning tool built into electronic health records can help doctors spot patients at high risk for opioid overdose. Researchers are testing it in 13 clinics in Florida with about 674 patients. The tool sends an alert when a doctor prescribes …

This study was designed to observe people with infected knee replacements who receive an antibiotic spacer. Researchers planned to measure antibiotic levels in joint fluid after surgery using mass spectrometry. The goal was to understand how well the antibiotics work and track co…

This study gives families of infants a kit with special devices to use during video doctor visits from home. The goal is to see if this approach is practical and if caregivers like it. About 100 families will try the kit and share their experiences through surveys.

This study tests a training program for prenatal healthcare providers to help them use proven treatments for opioid use disorder during pregnancy. Researchers will look at how the program affects the use of medication-assisted treatment and health outcomes for mothers and babies.…

This study looks at lung tissue from 80 people with pulmonary fibrosis to find unique genetic markers linked to scarring. By analyzing gene activity in the tissue, researchers hope to uncover how the lung gets damaged. The goal is to pave the way for better diagnosis and treatmen…