University Of Pittsburgh

This is a small pilot study to test if a new school-based support program is practical and helpful for children with type 1 diabetes. The program connects school nurses, families, and diabetes specialists through virtual meetings to create a shared care plan. The main goal is to …

This study is testing a new way to improve care for people with opioid addiction. It involves patients regularly tracking their symptoms and recovery progress using simple tools, then discussing this information with their treatment providers. The goal is to see if this shared tr…

This study tests whether monthly automated blood exchange transfusions can reduce hospital visits and prevent deaths in adults with sickle cell disease who are at high risk of heart and lung complications. Researchers will compare the transfusion approach against standard care in…

This study compares two different family therapy approaches for teenagers with anorexia, both delivered in the home setting. Researchers want to see if providing treatment at home makes it more accessible and effective for families. They're measuring weight changes, eating behavi…

This study is testing a new support program for people recovering after a serious illness that required intensive care (ICU). The program provides telehealth check-ins to help with health management, rehabilitation, social support, and care coordination for patients and their fam…

This study aims to find out if adding a small stomach drainage procedure (called a pyloroplasty) during major esophageal cancer surgery leads to better recovery. About 143 patients having their esophagus removed will be randomly assigned to get the extra procedure or not. Researc…

This study aims to find the best way to get hospitals to consistently use proven breathing support methods after a patient's breathing tube is removed in the Intensive Care Unit (ICU). It will test different combinations of staff training and treatment protocols across many ICUs.…

This large international study aims to find the best surgical method to prevent repeat ACL injuries in young, active patients. It compares two common types of tendon grafts taken from the patient's own knee, with or without an extra stabilizing procedure. The goal is to reduce th…

This study is testing a new telehealth program designed to help young adults (ages 18-26) with type 1 diabetes better manage their condition. The program uses group video calls led by diabetes educators to teach self-care skills, aiming to improve attendance at education sessions…

This study is testing whether daily phone reminders can help people with schizophrenia remember to take their medication. Researchers are comparing two groups of about 100 participants: one receives the reminders, and the other receives standard care. The goal is to see if the re…

This study is testing a new, less invasive method to find sperm in men who have no sperm in their semen (azoospermia). Doctors use ultrasound to guide a needle into a specific part of the testicle to flush out and collect fluid, hoping to find usable sperm for fertility treatment…

This study tests a training program for prenatal care doctors to help them better treat opioid addiction during pregnancy. The program provides education, remote support, and case management to help doctors use recommended medications. Researchers will measure if this training le…

This study is testing a coordinated care program designed to help pregnant and postpartum women with opioid addiction in rural, low-resource areas. The program aims to help women start and stay on addiction medication, reduce overdose risk, and lower the chance of children being …

This study is testing whether a brief, computer-based brain training program can make ketamine's rapid antidepressant effects stronger and longer-lasting. It involves 600 adults with treatment-resistant depression who are already scheduled to receive ketamine treatment as part of…

This study is testing whether a 4-week mindfulness training program delivered through a smartphone app can help reduce stress and improve blood pressure in adults aged 45+ who are at risk for heart disease. About 105 participants were randomly assigned to either use the daily min…

This study aims to find the best schedule for treating severe knee ligament injuries. It compares whether having surgery and starting physical therapy earlier or later helps military personnel and civilians return to their jobs and sports activities more quickly and completely. T…

This study is testing if patients can safely put weight on their leg and walk sooner after common hip surgery for a torn labrum and impingement. It compares the standard approach of using crutches for weeks with a new protocol that allows walking as tolerated right after surgery.…

This study compares two different exercise tests used to assess recovery in teenagers with recent sports concussions. Researchers want to see if a newer test that involves changing direction causes different symptoms than a standard treadmill test. About 60 teens aged 14-17 will …

This study aims to use a special brain scan called diffusion tensor imaging (DTI) to identify which newborns with Krabbe disease need immediate treatment. Researchers will follow 100 infants with low enzyme levels to see if brain scans can predict which babies will develop the ra…

This Pennsylvania-based study aims to understand and reduce differences in heart disease risk among different groups. Researchers are following 2,000 adults to identify who is at highest risk. About 800 higher-risk participants will try a special education program focused on diet…

This large community program aims to prevent future behavioral and developmental problems in young children by making proven support services easier for families to access. It works by first understanding a family's needs, then offering a tailored menu of parenting and child deve…

This study is looking at how the quality of the relationship between a caregiver and their family support coach might help prevent child maltreatment. Researchers are studying over 600 caregivers in Ohio who are participating in a community program designed to build family streng…

This study is testing a mental health support program called 'Nae Disha for Life' in schools in India. The goal is to see if the program is practical and helpful for reducing suicidal thoughts and building resilience in students aged 12-17. Researchers will compare students who r…

This study is testing a community program called Forging Hopeful Futures that aims to prevent violence among teenagers. The program combines job readiness training with education about racial and gender justice to help teens build better coping and leadership skills. It involves …

This study is testing if a chatbot named SMILEY can help teens who are depressed and have been bullied online. The chatbot teaches coping skills and safe social media practices over four weeks. Researchers want to see if using SMILEY makes teens feel less stressed and safer onlin…

This study is testing a sleep therapy program designed for cancer patients and their intimate partners who share a bed. The goal is to help both people in the couple improve their sleep quality and overall well-being. The program is a modified version of cognitive behavioral ther…

This study is testing whether a computer-based brain training program can make depression treatment more effective. It involves 40 adults who are already receiving esketamine treatment for depression at a clinic. Researchers want to see if this training helps the brain learn in m…

This study is testing a web-based support program designed to help advanced cancer patients manage symptoms like depression, pain, and fatigue. It also aims to reduce stress and depression in their spouses or partners who are providing care. The program is intended to be accessib…

This study is testing whether a tablet-based symptom management program can help people with advanced cancer who live in rural areas. Participants are randomly assigned to either use the 'Nurse AMIE' app or receive a supportive care book. The main goal is to see if using the app …

This study is developing and testing a virtual family therapy program for families where a parent died by suicide at least a year ago. It aims to help both the surviving parent and children aged 8-14 manage severe, long-lasting grief. The therapy is adapted from a proven adult tr…

This study is preparing for a larger trial to test whether manual therapy, exercise, and a form of electroacupuncture can help people with lumbar spinal stenosis. The goal is to reduce pain, improve walking ability, and potentially limit the need for spinal surgery. Researchers w…

This study is testing a special video game designed to teach women with advanced cancer how to better speak up for themselves with their doctors and manage their care. The game lets players make decisions for characters facing similar cancer challenges to learn communication and …

This study is testing whether a specific 6-week yoga program can help improve thinking skills like memory, focus, and mental flexibility in people whose depression is in remission. It will compare 76 participants who either do the yoga program plus their usual treatment or just c…

This study is testing whether a special type of video therapy, delivered on a smartphone or computer, can help improve memory and concentration problems that some people experience after chemotherapy for breast cancer. Researchers are comparing this therapy to a standard supporti…

This study is testing a 6-session online program called 'Maximizing Energy' to see if it can help women who have finished breast cancer treatment manage their persistent fatigue. Researchers will enroll 50 survivors to compare this program against a general health education cours…

This study is testing whether a group exercise program called 'On the Move' can help older adults walk faster and feel more mobile. Researchers are working with 502 people at 44 community centers to see if regular classes taught by local instructors make a difference. They will m…

This study aims to understand if bleeding during a dental check-up around an implant can warn dentists about future bone loss or gum disease. 150 participants with dental implants will attend six check-up visits over 15 months, where their gums and bone will be measured. The goal…

This study aims to understand if the shape of the underside of a full dental implant bridge is linked to bone loss around the implants, a condition called peri-implantitis. Researchers will examine 50 adults who have had a specific type of upper-jaw implant bridge for at least on…

This research study aims to better understand how a specific part of the brain's hearing center contributes to processing speech sounds. Researchers will test a small group of young people who have already had surgery to remove a lesion from a specific brain area. The goal is to …

This study aims to understand why and how the lungs scar in people with pulmonary fibrosis. Researchers will analyze leftover tissue from lung biopsies of 80 participants to look for unique genetic markers. The goal is to gather knowledge that could lead to new ways to diagnose a…

This study uses brain scans to understand how the brain controls the bladder and why this control can fail with age, leading to urge incontinence. Researchers are comparing brain activity and structure in older and younger women, both with and without incontinence. The goal is to…

This study is testing whether a one-hour online training program can help people who use wheelchairs improve how they move in and out of their chairs. Researchers want to see if this remote training can reduce shoulder pain and make daily life easier. They are enrolling 200 wheel…

This study is testing if a special training program for doctors makes them more likely to refer their inactive patients to a free telephone coaching service. The coaching, called MoveLine, helps people become more physically active to lower their risk of several cancers. About 48…

This study is testing whether fitness trackers and daily smartphone surveys can help spot early warning signs in patients recovering from major bladder surgery. The goal is to see if this remote monitoring can help healthcare providers respond quickly to potential problems, aimin…

This study aims to understand the challenges and opportunities for improving mental health support for young people in schools in Chennai, India. Researchers will conduct in-depth interviews with students, teachers, parents, and school staff to learn about the current school envi…

This study, which was withdrawn before starting, planned to observe adults with infected knee replacements. Researchers aimed to measure antibiotic levels released from a temporary spacer placed during surgery and see how those levels related to patients' recovery, pain, and need…

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This study is testing a new blood test to see if it can detect the return of stage III colon or rectal cancer earlier than current methods. Researchers are following 137 patients for up to 5 years, collecting blood samples regularly to look for tiny pieces of cancer DNA. The goal…

This study is testing if a personalized medication review from a pharmacist is more effective when it includes a person's genetic test results. It involves 600 adult employees from the University of Pittsburgh and UPMC health system who have already had genetic testing. Researche…

This study aims to understand how gums around dental implants that were previously treated for infection heal. Researchers will temporarily allow mild gum inflammation to develop around healthy, treated implants, then observe how the gums recover when normal cleaning resumes. The…

This study aims to find the best way for healthcare systems to get more veterans screened for colon and liver cancer. It will compare two approaches: directly helping patients navigate the screening process versus helping clinics fix system-level barriers. Researchers will track …

This study aims to find out if a remote training program helps rehabilitation clinicians become more skilled and confident at teaching wheelchair skills to people with leg paralysis. It compares three approaches: full remote training with feedback, a basic video course, and a sel…

This study is testing if it's practical and helpful to give families of young infants a kit of simple medical devices to use during video doctor visits from home. The kits include items like a thermometer and an ear-checking tool. Researchers want to see if families find the kits…