University Of Pittsburgh

This study tests two different tendon grafts (kneecap tendon vs. quadriceps tendon) for ACL reconstruction, with or without an extra stabilizing procedure called lateral extra-articular tenodesis (LET). The goal is to see which approach best prevents graft failure in 1,272 young,…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether a mobile app can help parents of children aged 5-8 with disruptive behavior. 324 families will use either a standalone app, a coach-assisted app, or a control app. The goal is to see if digital tools can improve parenting skills and child behavior at a la…

This study tests a new program where schools, families, and doctors work together to help children manage type 1 diabetes. About 30 kids will take part to see if the program is practical and well-liked. The goal is to improve daily diabetes care at school.

This study looks at whether allowing a slightly higher blood sugar range (70-110 mg/dL) during labor in mothers with diabetes can reduce the number of newborns with low blood sugar. Researchers will compare this approach to standard care in 169 pregnant women planning a vaginal d…

This study tests whether daily phone reminders can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 participants will receive repeated cues on their mobile phones for 30 days. The goal is to see if this improves medication adherenc…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis undergoing lumbar spine surgery. Participants would have received monthly injections of romosozumab or weekly alendronate pills for 12 months. How…

This Phase 3 trial tests whether automated red cell exchange (a procedure that replaces a patient's sickled red blood cells with healthy donor cells) plus standard care can reduce hospital visits and deaths in adults with sickle cell disease at high risk. About 173 participants w…

This study looks at using radiofrequency ablation (RFA) — a procedure that uses heat to destroy tumors — to treat lung cancer or tumors that have spread to the lungs. It is for patients who cannot have surgery due to other health issues. The goal is to see if RFA can control tumo…

This study was designed to test a combination of two drugs—golcadomide and nivolumab—in people with non-Hodgkin lymphoma whose cancer did not respond or came back after CAR-T cell therapy. The goal was to find a safe dose and see if the combo could shrink tumors. However, the tri…

This study tests a non-surgical method to collect sperm from men with a condition called azoospermia, where no sperm is found in the semen. Using ultrasound guidance, doctors flush and suction fluid from a part of the testicle to retrieve sperm. If successful, this could help inf…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This study looks at whether a special brain scan called diffusion tensor imaging (DTI) can help doctors find Krabbe disease in newborns and decide who needs urgent treatment. About 100 babies with a positive newborn screen or family history of Krabbe disease will be scanned and f…

This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT) can prevent bipolar disorder in teenagers (ages 12-18) who have a parent with bipolar disorder and are considered high-risk. Participants receive 8 sessions of IPSRT or a health…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This study tests two 18-month talk therapy programs—Cognitive Enhancement Therapy and Enriched Supportive Therapy—for people with schizophrenia who have lasting negative symptoms like low motivation and social withdrawal. About 90 outpatients aged 18-60 will participate. The goal…

This study tests whether a serious video game called Strong Together can help women with advanced cancer learn self-advocacy skills. Participants play through scenarios where they make decisions for characters with cancer, learning how to communicate better with doctors and manag…

This study compares two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on behavior, the other adds sleep strategies. Researchers want to see if the sleep-focused approach is more helpful and practical for families in pe…

This pilot study tests a program called ALIGN, designed to help adults with spina bifida improve how they manage health tasks like coordinating care and handling medications. The program includes six virtual group sessions and one individual session with a clinician. Researchers …

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Over 4 weeks, participants interact with the chatbot at their own pace to learn how to m…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study aimed to see if a computer-based cognitive training program could improve spatial thinking, balance, and quality of life in people with long-term dizziness from inner ear problems. The training was meant to be used alongside standard physical therapy. However, the stud…

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do eithe…

This study is testing a family-focused therapy for families who lost a parent to suicide at least a year ago. It includes 30 families with children aged 8-14 who are struggling with prolonged grief. The therapy is done online and aims to reduce grief symptoms in both parents and …

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study tests an electronic symptom management system called Nurse AMIE in 344 people with stage 3 or 4 cancer living in rural areas. The goal is to see if using the system helps them live longer and improves their quality of life. Participants use the system to report symptom…

This study tests a mobile cognitive-behavioral therapy program called MAAT to help breast cancer survivors who have memory and concentration problems after chemotherapy. About 220 survivors who finished chemo 1-5 years ago will either use MAAT or receive supportive therapy. The g…

This study tests whether adding a computer-based cognitive training program can improve depression relief for people already receiving esketamine treatment. Researchers will enroll up to 40 adults aged 18-80 at the University of Pittsburgh. The goal is to see if this approach can…

This study tests a program called Nae Disha for Life to see if it can reduce suicide thoughts in young people aged 12-17 in rural India. About 272 students from 4 schools will take part. The program teaches resilience and coping skills to help ease suicidal thoughts and anxiety.

This study tests a group exercise program called On the Move for older adults in senior centers. Over 500 participants aged 60 and older will take part in 50-minute classes twice a week for 12 weeks. The goal is to see if the program improves walking speed and overall mobility.

This study looks at 300 pregnant women who have an epidural during labor. It compares leaving a catheter in place all the time versus inserting and removing it every few hours. The goal is to see which method leads to fewer bladder issues and infections after giving birth.

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study uses electronic health records and patient surveys from 1500 adults to explore how healthy lifestyles and body weight relate to healthcare use. Researchers aim to create a network that allows future patient-centered studies on weight across multiple institutions. It is…

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This pilot study tests whether an enhanced telemedicine program is practical for adults with complex type 2 diabetes who use insulin and have other health conditions. Fifty participants will receive either standard telemedicine care or an enhanced version with extra pre-visit pre…

This study follows 180 children with overweight or obesity to see how their thinking skills (like memory and self-control) relate to eating habits and weight changes over time. Researchers will use brain tasks and interviews to understand these links. The goal is to find better w…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study follows 164 adults with dental implants for 15 months to see if bleeding when the dentist probes the gums can predict bone loss around the implant. Participants attend check-ups every 3 months, where the dentist measures bleeding and takes X-rays to track bone levels. …

This study looks at different training methods for ICU staff to improve how they remove breathing tubes from patients. It involves over 13,000 adults on ventilators for more than 24 hours. The goal is to see if better education and care plans can reduce deaths and increase use of…

This study looks at ways to help adults in rural Pennsylvania become more physically active. It includes 880 people who are overweight, have type 2 diabetes, or are not very active. Researchers will track activity levels using questionnaires and wearable devices to see what works…

This study follows 2,500 people with gastroesophageal reflux disease (GERD) to compare how well medications and surgery work over time. Researchers will track quality of life, heartburn symptoms, and patient satisfaction. The goal is to identify who benefits most from each treatm…

This study compares two surgical approaches for people having their esophagus removed (esophagectomy): one group gets the standard surgery plus an extra drainage procedure on the stomach (pyloroplasty), and the other gets the standard surgery alone. The goal is to see if the extr…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study aims to understand the challenges and opportunities in improving school culture around mental health in Chennai, India. Researchers will interview students aged 12-18, teachers, parents, and school staff to identify what helps or hinders mental health support. The goal…

This study looks at whether training rural primary care providers can increase how often they refer inactive patients to a free, phone-based physical activity counseling service. About 48 providers from rural Pennsylvania clinics will receive the training. The goal is to see if t…

This study compares two strategies to increase colon and liver cancer screening among 30,300 veterans. One approach directly reaches out to veterans to schedule tests, while the other helps healthcare providers fix system issues. Researchers will track screening rates over 12 mon…

This study compares two treadmill tests—the Buffalo Concussion Treadmill Test and a modified dynamic exertion test—in teens aged 14-17 who had a sport-related concussion within the past 14 days. The goal is to see which test better measures symptoms like headache and dizziness, a…

This study was designed to observe how antibiotics work in patients with knee replacement infections. Researchers planned to measure antibiotic levels in joint fluid after placing a medicated spacer. The study was withdrawn before enrolling any participants, so no results or conc…

This study looks at whether having surgery earlier (within 6 weeks) or later (12-16 weeks) after a severe knee injury leads to better recovery. It also compares starting rehab early versus later after surgery. The trial includes 690 military personnel and civilians aged 16-55 wit…

This study looks at how the brain's temporal lobe helps process sound. Researchers will measure brain activity using EEG in 10 people who have had surgery to remove a lesion in a key hearing area. The goal is to better understand how the brain generates electrical responses to sp…

This study tests a telehealth program called PIC-TRFS for older adults (50+) who spent at least 48 hours in the ICU and are at risk for long-term problems. The program includes rehabilitation, health management, social support, and care coordination delivered over 6 months. Resea…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study tests whether an online training program can help wheelchair users improve their transfer technique and reduce shoulder pain. The program teaches proper wheelchair setup, body positioning, and transfer movements. Researchers are measuring changes in transfer skills and…

This large community study in Allegheny County is testing whether free text message programs (like Text4Baby) and mentor support can improve child development and parenting. Researchers will follow 24,000 families from birth through school entry, measuring things like self-contro…

This study involves 3,650 adults in 20 opioid treatment programs who are starting medication for opioid use disorder. Participants will use digital tools to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treat…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help monitor for cancer recurrence in people with stage III colorectal cancer. Researchers will follow 137 participants over time to see if ctDNA levels relate to survival and whether they are better …

This study looks at whether a pharmacist's review of your medications, combined with your genetic test results, can lead to better outcomes and lower costs. About 600 employees from the University of Pittsburgh and UPMC will take part. Half will get a medication review with genet…

This study looks at how well caregivers connect with their family coaches and whether that connection helps protect children from abuse or neglect. Researchers will follow 612 caregivers who are already in a prevention program to see if a good working relationship boosts family s…

This study looks at lung tissue from 80 people with pulmonary fibrosis to find unique genetic markers linked to scarring. By analyzing gene activity, researchers hope to better understand the disease and pave the way for new diagnostic tools and treatments. Participants must be 1…

This study looks at how dental implants heal from gum inflammation (peri-implant mucositis). Researchers will compare implants that were previously treated with or without a smoothing procedure called implantoplasty. Thirty adults with healthy implants will stop cleaning those ar…

This study examines whether the inner shape (concave or convex) of full-arch implant-supported dental prostheses is linked to bone loss around implants. Researchers will scan the prostheses and measure bone levels in 50 adults who have had these implants for at least a year. The …

This study looks at whether wearable fitness trackers like the Fitbit Sense 2 can help doctors spot early signs of complications in patients recovering from bladder removal surgery. Fifty participants will wear the device and answer daily surveys for up to two weeks before surger…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…