Can brain training beat Schizophrenia's 'Negative' symptoms?

NCT ID NCT04143126

Ongoing Symptom relief Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two 18-month talk therapy programs—Cognitive Enhancement Therapy and Enriched Supportive Therapy—for people with schizophrenia who have lasting negative symptoms like low motivation and social withdrawal. About 90 outpatients aged 18-60 will participate. The goal is to see if these therapies can reduce these symptoms and improve daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive Enhancement Therapy and Enriched Supportive Therapy (talk therapy programs)
What this could lead to: If successful, this could provide a proven talk therapy option to reduce negative symptoms like lack of motivation and social withdrawal in schizophrenia.
What could go wrong: This is a mid-stage trial with 90 people, so results may not apply to everyone. The therapies are time-intensive (18 months), and benefits may be modest or not last long-term.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

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Other studies related to the condition(s) this trial covers.