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Freezing hope: new study aims to protect fertility in transgender youth

NCT ID NCT05829928

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at how to freeze and store testicular tissue from transgender individuals who are about to start gender-affirming hormone therapy. The goal is to learn the best ways to preserve sperm-producing cells so that these individuals might have the option to have biological children later. Participants donate a small piece of tissue during a scheduled surgery, which researchers then study and freeze using different methods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help transgender individuals preserve their ability to have biological children in the future.
What could go wrong
This is an early-stage study focused on lab techniques, not a treatment. It may not lead to a usable fertility option for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2019

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Eligible patients who will undergo gender-affirming treatments and for whom standard of care fertility preservation procedures are not available.

Ages

9 years and older

Sex

Male participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Category 1 participants must have all criteria listed below: * Patient with testes over the age of 9 * Diagnosed with gender dysphoria; currently on or imminently planning to start gender affirming treatment (hormone blockers or gender-affirming hormones) * Have a clinical referral for fertility preservation from their primary care physician * Unwilling to undergo natal puberty or, for patients who have gone through puberty, unwilling to discontinue hormone suppression and/or hormone replacement therapy. Category 2 participants only fall into this category if they are undergoing gender-affirming surgery. They must have all criteria listed below: * Patient is 18+ years old * Diagnosed with gender dysphoria * Unwilling to undergo natal puberty, or for patients who have gone through puberty, be unwilling to discontinue hormone suppression and/or sex steroid (estrogen) therapy. * Will be undergoing gender affirming surgery that involves removal of the testes. Exclusion Criteria: * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent. * Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.

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Conditions

The condition(s) this trial relates to.

Gender Dysphoria infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gender dysphoria Transgender

Contacts and locations

Locations

  • Magee-Womens Hospital

    Pittsburgh, Pennsylvania, 15213, United States

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