Freezing hope: new study aims to protect fertility in transgender youth

NCT ID NCT05829928

Ongoing Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at how to freeze and store testicular tissue from transgender individuals who are about to start gender-affirming hormone therapy. The goal is to learn the best ways to preserve sperm-producing cells so that these individuals might have the option to have biological children later. Participants donate a small piece of tissue during a scheduled surgery, which researchers then study and freeze using different methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help transgender individuals preserve their ability to have biological children in the future.
What could go wrong: This is an early-stage study focused on lab techniques, not a treatment. It may not lead to a usable fertility option for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gender Dysphoria infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENDER DYSPHORIA TRANSGENDER

Contacts and locations

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Locations

Magee-Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

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