Earlier hormone therapy: a lifeline for transgender teens?

NCT ID NCT06351501

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial looks at whether starting cross-sex hormones at age 13.5, rather than the usual 15.5, improves the well-being of adolescents with gender dysphoria. Participants will receive either testosterone or estrogen and be followed for four years. The study measures overall functioning, anxiety, depression, and quality of life to see if earlier treatment reduces distress and supports healthier development.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cross-sex hormones (testosterone or estrogen) given as gel or tablets
What this could lead to: If starting hormones earlier improves mental health and daily functioning, it could support earlier access to gender-affirming care for transgender teens.
What could go wrong: This is a relatively small trial, and results may not apply to all teens. Hormonal treatment carries potential side effects, and the benefit of earlier start is not yet proven.

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Conditions

The condition(s) this trial relates to.

Gender Dysphoria Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENDER DYSPHORIA

Contacts and locations

Locations

Service Endocrinologie et Diabète de l'enfant, CHU Le Kremlin Bicêtre
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, Île-de-France Region, 94270, France
Service d'Endocrinologie et Diabétologie Pédiatrique, CHU Robert Debré
RECRUITING

Paris, 75019, France
Service de Psychiatrie de l'enfant et de l'adolescent, CHU Robert Debré
RECRUITING

Paris, 75019, France
Service de psychiatrie de l'enfant et de l'adolescent, GH Pitié-Salpêtrière
RECRUITING

Paris, 75013, France

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