New study aims to freeze ovarian tissue for transgender fertility

NCT ID NCT05863676

Ongoing Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at how to best freeze and store ovarian tissue for transgender individuals who are undergoing gender-affirming therapy. The goal is to preserve the possibility of having biological children later. Researchers will test different freezing methods and examine how hormone treatments affect the tissue. Participants are transgender individuals with ovaries who are planning or already receiving gender-affirming hormones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could improve fertility preservation options for transgender individuals who cannot or do not wish to undergo natal puberty.
What could go wrong: This is a small, early-stage study focused on tissue analysis, not on actual fertility outcomes. The techniques may not lead to successful pregnancies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gender Dysphoria infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENDER DYSPHORIA TRANSGENDER

Contacts and locations

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Locations

Magee-Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

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