Gastric bypass secrets: intestine rewires metabolism
NCT ID NCT02710370
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to one year after surgery. They will analyze the cells, genes, and metabolites to understand these metabolic changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could reveal how the intestine drives metabolic improvements after gastric bypass, potentially pointing to new treatments for obesity and type 2 diabetes.
- What could go wrong
- This is an observational study with only 46 participants, so findings may not apply to everyone. It looks at biological changes, not a new treatment, so direct benefits are not guaranteed.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
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