METABOLIC DISEASES

This study tests whether 4 weeks of high-intensity interval training (HIIT) or time-restricted eating (TRE) can improve health markers linked to type 2 diabetes in teens and young adults with overweight or obesity. Researchers will measure weight, blood sugar, insulin, and other …

This study tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a genetic disease that damages nerves. The goal is to see if the treatment can stop or slow the disease by lowering a harmfu…

This study looks at how a person's genes influence their body's response to oral semaglutide, a medication used for type 2 diabetes. About 125 adults with normal to pre-diabetes blood sugar levels will take the drug for two weeks and have their blood tested after a standardized b…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases (like diabetes). Researchers will collect medical records, imaging, and lab results, then follow participants for up to 5 years. The goal is to better understand how these conditions…

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand what leads to earlier death and po…

This study uses MRI scans to compare the brains of people with metabolic diseases (like obesity or diabetes) to healthy volunteers. Researchers want to see if there are differences in brain structure, function, and chemistry, and how these change over time. No treatments are test…

This study looks at why ultra-processed foods (like chips and sugary snacks) make us overeat. Researchers will measure how these foods affect blood sugar, insulin, and metabolism in 74 healthy adults, and use brain scans to see how much people value them. The goal is to understan…

This study looks at the genes of 2,750 adults in French Polynesia to find links between inherited traits and diseases like gout, inflammation, and diabetes. Participants include both healthy volunteers and people with gout. The goal is to better understand why these conditions oc…

This study looks at how well patients with inherited metabolic diseases follow their daily oral medication plans. Researchers will survey 200 patients and their parents at Necker Hospital to measure adherence and assess disease knowledge. The goal is to see if a special education…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc levels inside cells and how well blood vessels work. The goal is to understand how…