Blood swap breakthrough: can exchange transfusions save sickle cell patients?

NCT ID NCT04084080

Ongoing Disease control Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether automated red cell exchange (a procedure that replaces a patient's sickled red blood cells with healthy donor cells) plus standard care can reduce hospital visits and deaths in adults with sickle cell disease at high risk. About 173 participants will be randomly assigned to receive either the exchange transfusions or standard care alone, and researchers will track health events over 13 months. The goal is to see if this approach can prevent sudden worsening of the disease.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE

Contacts and locations

Locations

Atrium Health

Charlotte, North Carolina, 28204, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Duke University

Durham, North Carolina, 27708, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Emory University

Atlanta, Georgia, 30322, United States
Hemorio

Rio de Janeiro, Brazil
Henri Mondor Hopital

Paris, France
Howard University Center for Sickle Cell Disease

Washington D.C., District of Columbia, 20060, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Johns Hopkins University

Baltimore, Maryland, 21206, United States
Kremlin-Bicêtre

Créteil, France
Montefiore Medical Center

New York, New York, 10461, United States
Ohio State University

Columbus, Ohio, 43210, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama

Tuscaloosa, Alabama, 35401, United States
University of Illinois at Chicago

Chicago, Illinois, 60607, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
Virginia Commonwealth University

Richmond, Virginia, 23284, United States
Washington University-St. Louis

St Louis, Missouri, 63110, United States

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