Blood swap breakthrough: can exchange transfusions save sickle cell patients?
NCT ID NCT04084080
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether automated red cell exchange (a procedure that replaces a patient's sickled red blood cells with healthy donor cells) plus standard care can reduce hospital visits and deaths in adults with sickle cell disease at high risk. About 173 participants will be randomly assigned to receive either the exchange transfusions or standard care alone, and researchers will track health events over 13 months. The goal is to see if this approach can prevent sudden worsening of the disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atrium Health
Charlotte, North Carolina, 28204, United States
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Duke University
Durham, North Carolina, 27708, United States
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East Carolina University
Greenville, North Carolina, 27834, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Hemorio
Rio de Janeiro, Brazil
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Henri Mondor Hopital
Paris, France
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Howard University Center for Sickle Cell Disease
Washington D.C., District of Columbia, 20060, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Johns Hopkins University
Baltimore, Maryland, 21206, United States
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Kremlin-Bicêtre
Créteil, France
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Montefiore Medical Center
New York, New York, 10461, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Alabama
Tuscaloosa, Alabama, 35401, United States
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University of Illinois at Chicago
Chicago, Illinois, 60607, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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Virginia Commonwealth University
Richmond, Virginia, 23284, United States
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Washington University-St. Louis
St Louis, Missouri, 63110, United States