Teen therapy aims to stop bipolar before it starts

NCT ID NCT04815239

Ongoing Prevention Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT) can prevent bipolar disorder in teenagers (ages 12-18) who have a parent with bipolar disorder and are considered high-risk. Participants receive 8 sessions of IPSRT or a healthy lifestyle program via video call, and are followed for 18 months. The goal is to see if stabilizing sleep and daily routines can reduce manic symptoms and mood swings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Interpersonal and Social Rhythm Therapy (IPSRT) – a behavioral therapy that helps stabilize sleep and daily routines
What this could lead to: If it works, this could point toward a way to prevent or delay bipolar disorder in teenagers who are at high genetic risk.
What could go wrong: This is a relatively small, early-stage trial. The therapy may not prevent bipolar episodes, and results may not apply to all at-risk youth.

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Conditions

The condition(s) this trial relates to.

bipolar disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER

Contacts and locations

Locations

Nicole Arnold

Pittsburgh, Pennsylvania, 15213, United States

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