Teen therapy aims to stop bipolar before it starts
NCT ID NCT04815239
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT) can prevent bipolar disorder in teenagers (ages 12-18) who have a parent with bipolar disorder and are considered high-risk. Participants receive 8 sessions of IPSRT or a healthy lifestyle program via video call, and are followed for 18 months. The goal is to see if stabilizing sleep and daily routines can reduce manic symptoms and mood swings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Interpersonal and Social Rhythm Therapy (IPSRT) – a behavioral therapy that helps stabilize sleep and daily routines
What this could lead to
If it works, this could point toward a way to prevent or delay bipolar disorder in teenagers who are at high genetic risk.
What could go wrong
This is a relatively small, early-stage trial. The therapy may not prevent bipolar episodes, and results may not apply to all at-risk youth.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Nicole Arnold
Pittsburgh, Pennsylvania, 15213, United States