BIPOLAR DISORDER

This study is testing whether a specialized metabolic health clinic can help people with severe mental illnesses like schizophrenia or bipolar disorder manage weight gain and other health risks caused by their antipsychotic medications. The clinic will provide focused care on die…

This study is testing whether adding an investigational medication called KarXT to standard mood stabilizers helps reduce manic symptoms in people with Bipolar I disorder. Researchers will compare KarXT against a placebo in 424 hospitalized adults currently experiencing a manic e…

This study is testing a flexible, personalized approach to therapy booster sessions for young people with or at risk for bipolar disorder. Participants who have already completed a year of specialized therapy can choose the type and frequency of follow-up sessions that work best …

This study is testing if a daily eating schedule, called time-restricted eating, can help people better manage their bipolar disorder symptoms when used alongside their regular medications. Researchers will enroll 150 adults with bipolar disorder who also have sleep issues. Parti…

This study is testing whether an investigational medicine called azetukalner can help reduce depressive symptoms in adults with bipolar I or II disorder. About 400 participants will be randomly assigned to receive either the study drug or a placebo for 6 weeks. Researchers will m…

This study is testing whether taking a low-dose melatonin supplement (a hormone that helps regulate sleep) along with a behavioral sleep coaching program can help shift the body's internal clock earlier and improve both mood and sleep in people with bipolar disorder. Researchers …

This study is testing a one-year therapy program for 60 teens and young adults who have bipolar disorder or are at risk for it because a close family member has it. The therapy, called Dialectical Behavior Therapy (DBT), teaches skills to manage intense emotions and reduce risky …

This study is testing whether adding five extra support elements to standard early psychosis care helps young adults stay engaged in treatment. The enhanced program includes peer support, family therapy, digital outreach, care coordination, and cognitive training. Researchers wil…

This study is testing whether adding a medication called bezafibrate to a person's current mood-stabilizing drugs can help reduce symptoms of depression in people with bipolar disorder. It will involve 30 adults over 8 weeks to check if the treatment is safe and shows signs of wo…

This study is testing a more flexible, personalized approach to therapy for teens and young adults who have bipolar disorder or are at risk for it because a close family member has it. Instead of a one-size-fits-all program, it offers three different levels of therapy intensity, …

This study tests whether a new, lower-power version of electroconvulsive therapy (ECT) works better for reducing suicidal thoughts than standard ECT. Researchers will compare both treatments in 30 adults with severe depression, bipolar disorder, or related conditions who have sui…

This study is testing whether a very brief, 4-minute high-intensity treadmill workout is as helpful as a longer, standard 20-minute workout for people with schizophrenia or bipolar disorder. Researchers want to see if the shorter workout is easier for people to stick with over 6 …

This study is testing whether adding an investigational medication called brenipatide to a person's current bipolar disorder treatment can help delay the return or worsening of symptoms. It will involve about 400 adults with bipolar disorder who will receive either brenipatide or…

This study is testing a medication called valbenazine for people with tardive dyskinesia (TD), which causes uncontrollable movements. It is for adults with TD who still have symptoms while taking a similar medication or after stopping one. The main goal is to see if switching to …

This study compares two brain stimulation treatments for people with severe bipolar depression or depression that hasn't responded to medications. Researchers want to see if magnetic seizure therapy works as well as electroconvulsive therapy but with fewer side effects, particula…

This study is exploring whether a non-invasive brain stimulation technique can improve thinking problems and mood in people with several brain-based conditions. Researchers will use a magnetic coil placed on the head to stimulate a part of the brain called the cerebellum in 200 p…

This study is testing whether a special therapy delivered by video call can help prevent bipolar disorder in teenagers who have a parent with the condition and are at high risk. Researchers will compare two different online programs—one focused on stabilizing daily routines and s…

This study is testing whether a specific type of talk therapy, called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), can help veterans who have both serious mental illness and chronic back pain. Researchers will compare the therapy to a general health education program i…

This study is testing a 12-week group program designed to help young adults with conditions like schizophrenia, bipolar disorder, or major depression improve their skills for romantic relationships. The program focuses on communication, emotional understanding, and building healt…

This study is testing whether a program called 'Taking Action,' led by trained peers, can help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia. About 300 students will be randomly assigned to either try the five-session program o…

This study is testing whether a personalized mobile therapy app is as good as a standard version at helping young adults with anxiety, depression, or bipolar disorder. About 100 participants will use one of two versions of the 'Maya' app for six weeks. Researchers will compare ho…

This study is testing whether a non-invasive brain stimulation technique called iTBS can help reduce depression symptoms in people with bipolar disorder who haven't responded well to other treatments. Participants will receive either real or sham stimulation for 30 days, with res…

This study is testing whether light therapy and a short education program can help people with bipolar disorder who have sleep and daily rhythm problems. The goal is to see if these non-drug approaches can improve symptoms and reduce the number of days patients need to spend in t…

This study is testing a computer-based brain training program for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to see if this training can improve thinking skills, reduce symptoms, and help with daily life activities. Researche…

This study is testing a new social skills training program designed to help Veterans with serious mental health conditions. The program teaches skills for understanding social cues and navigating work relationships, aiming to improve job success and quality of life. Researchers a…

This study aims to create a detailed picture of bipolar disorder by observing 3000 patients across Norway over several years. Researchers will collect information about symptoms, genetics, brain scans, and daily functioning to understand how the condition varies between people. T…

This study aims to understand why young adults with bipolar disorder are at high risk for developing alcohol use disorders. Researchers will follow 160 young adults (half with bipolar disorder) for two years, using brain scans and controlled alcohol sessions to see how stress and…

This study aims to understand how a ketogenic diet (a high-fat, low-carb diet) affects the brain and mood in people with bipolar disorder. Researchers will enroll 107 adults, including people with bipolar disorder and healthy volunteers, to measure brain activity, metabolism, and…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This French research study aims to understand how people with schizophrenia or bipolar disorder experience the flow of time differently. Researchers will use virtual reality games and brain wave recordings (EEG) to measure time perception in 120 participants, including patients a…

This study aims to understand the connection between physical activity, sleep, and mental health in people with and without mood disorders like bipolar disorder and depression. Over 1,200 participants, including patients and their healthy family members, will wear activity monito…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This study aims to better understand how young people (ages 9-19) with bipolar disorder respond to treatment over one year. Researchers at four US clinics will follow 80 youth and their families, providing standard care while tracking mood, family relationships, and quality of li…

This study aims to find new brain-based markers for psychosis by measuring visual processing in people with schizophrenia, bipolar disorder, and healthy controls. Researchers will use EEG (electroencephalography) to record brain waves while participants view images. The goal is t…

This study aims to observe and understand how olanzapine is used to treat bipolar disorder in real-world settings. It will follow 3,000 patients to see what other treatments they receive and if providing education about weight gain, a common side effect, helps prevent it. The goa…

This study aims to understand if a mild, non-invasive brain stimulation technique can improve thinking skills like memory, focus, and decision-making. It will involve 600 people with conditions such as depression, ADHD, bipolar disorder, or a history of brain injury, as well as h…

This study aims to find objective biological markers in the brain to help diagnose and track treatment for severe mental disorders like depression, schizophrenia, and bipolar disorder. Researchers will use a powerful 7T MRI scanner and vision tests to compare brain chemistry and …

This study aims to better understand how people with bipolar disorder think and process information. Researchers will use eye-tracking technology to measure how 100 adults with bipolar disorder, with or without anxiety or substance use, look at faces and respond to rewards. The g…