Could a ketone drink calm the bipolar brain?
NCT ID NCT06373016
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how two types of energy—glucose and ketones—change brain activity and behavior in people with bipolar disorder. Participants will have MRI scans while playing money-winning games, before and after drinking either glucose or ketones. Researchers will compare results between people with bipolar disorder and healthy volunteers to understand how the brain uses energy differently.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Glucose and ketone drinks
What this could lead to
If successful, this could reveal how diet-based energy sources like ketones might stabilize brain networks in bipolar disorder, pointing toward future dietary or metabolic therapies.
What could go wrong
This is an early-stage observational study with only 100 participants, not a treatment trial. Results may not lead to direct clinical changes or apply to all people with bipolar disorder.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Laufer Center for Physical and Quantitative Biology , Stony Brook University
ACTIVE_NOT_RECRUITINGStony Brook, New York, 11794, United States
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Martinos Center for Biomedical Research, Building 149, 13th Street
RECRUITINGCharlestown, Massachusetts, 02129, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••