BIPOLAR DISORDER

This study tests whether tracking smartphone activity and offering extra support from peer specialists can help veterans with serious mental illness avoid emergency room visits and hospital stays. About 400 veterans who are at high risk will take part. The goal is to catch early …

This study looks at whether extra education from a pharmacist can help people aged 18-60 who are starting a new antipsychotic medication for conditions like schizophrenia or bipolar disorder. The goal is to see if this support reduces weight gain and other metabolic side effects.…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This pilot study will test whether a high-fat, low-carbohydrate ketogenic diet can reduce symptoms of bipolar disorder when added to standard treatments. The study will enroll 100 adults in rural Alabama and measure changes in mania severity. The goal is to see if a dietary appro…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests an 8-session psychoeducational program called 'Key to Emotional Balance' for adults with bipolar disorder. The program uses positive psychotherapy to help people better regulate their emotions, support recovery, and find more meaning in life. Researchers will com…

This study will test if art therapy sessions can lower anxiety and disease severity in 48 adults hospitalized in a psychiatry ward. Participants will be randomly assigned to receive art therapy plus standard care or standard care alone. The goal is to see if creative expression c…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study will use brain scans and thinking tests to compare how people with bipolar disorder and major depression control their impulses. Researchers want to find differences in brain activity that could help doctors make a more accurate diagnosis. The study involves 120 adults…

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers will measure these factors …

This study will follow 12 people with severe OCD or bipolar disorder who are already scheduled to receive deep brain stimulation (DBS). Researchers will use the DBS device to record brain activity while participants wear smart rings, watches, and phones to track sleep, activity, …

This study will create a large biobank of blood samples and detailed health information from 1,000 people with bipolar disorder in Turkey. Researchers will collect DNA and clinical data to better understand the condition and find genetic clues that could improve diagnosis and tre…