BIPOLAR DISORDER

This study tested a special program to help people with both bipolar disorder and substance use problems stick with their treatment after leaving the hospital. 178 adults took part, with half getting the new program and half getting extra safety checks, both added to their usual …

This study tested whether a 4-week ketogenic diet (very low carb, high fat) could improve brain function and thinking skills in 71 adults with schizophrenia or bipolar disorder. The idea is that ketones, which the body makes on this diet, may provide better energy to the brain th…

This study tested whether adding aripiprazole to lamotrigine helps prevent mood episodes in people with bipolar I disorder who recently had a manic or mixed episode. Over 1,100 adults took part and were followed for up to a year. The main goal was to see if the combination reduce…

This study tested a program called CARE to help people with bipolar disorder stick to their treatment after leaving prison. 18 adults about to be released took part. The goal was to see if the program was helpful and could improve mood symptoms.

This study compared two ways to help people with serious mental illness quit smoking: a smartphone app designed for them (Quit on the Go) versus standard care. 343 participants were followed for 6 months to see who stopped smoking, verified by a breath test. The goal was to find …

This study tested a culturally adapted psychoeducation program (CaPE) for people with bipolar disorder in Pakistan. 303 adults in remission were randomly assigned to receive CaPE plus usual care or usual care alone. The goal was to see if CaPE could reduce the time to a mood epis…

This study tested a special support program for veterans who have both bipolar disorder and substance use problems after they leave the hospital. 138 veterans took part, with half receiving the new program and half getting extra safety monitoring, both added to their usual care. …

This small pilot study tested a new support program called CARE for people with bipolar disorder who were leaving prison. The program provided counseling sessions and follow-up phone calls to help participants stick with their mental health treatment after release. Researchers wa…

This study tested a special nursing program for 60 family caregivers of people with bipolar disorder. The program aimed to reduce their stress and help them feel more emotionally strong and positive. Caregivers learned coping skills and emotional regulation techniques over 12 wee…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills and daily functioning in 62 adults with stable mood disorders (like depression or bipolar disorder) or psychosis spectrum disorders (like schizophrenia). Participants used VR to…

This study tested a new type of brain stimulation (rTMS) to help teenagers with bipolar disorder who are in a depressive episode. The treatment uses a magnetic field to target a specific brain area linked to emotions. The study included 40 people aged 14-28 and measured changes i…

This small pilot study tested whether a ketone supplement plus a special diet could help people with bipolar disorder. Fifteen adults took part, and researchers measured changes in blood ketone and glucose levels. The goal was to see if this approach is safe and worth studying fu…

This study looked at how well valbenazine works for tardive dyskinesia, a condition causing uncontrollable movements often linked to psychiatric medications. Fifty-nine adults with schizophrenia, bipolar disorder, or major depression took valbenazine for up to 24 weeks. Researche…

This study tested a noninvasive brain stimulation technique called transcranial random noise stimulation to see if it could reduce cravings in 225 adults with substance use disorder plus another mental health condition like ADHD, bipolar disorder, or schizophrenia. Participants r…

This study tested a computer-based cognitive training program in 72 adults with bipolar disorder who also had psychosis. The goal was to see if the training could improve memory, attention, and problem-solving skills compared to a control computer activity. Participants were with…

This study tested whether group-based psychoeducation (classes about bipolar disorder) could reduce stress and mood instability in relatives of people with bipolar disorder. 206 relatives participated, using a smartphone app to track their daily mood. The goal was to see if learn…

This study looked at whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression keep feeling better over 12 weeks. Forty-one adults who had already responded to an initial course of ketamine received up to six more infusions on a fl…

This study tested a non-drug program called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-guided strategies to regularize sleep and daily routines, aiming to lower short-term…

This small pilot study tested whether a non-invasive brain stimulation technique called TMS could help people with bipolar disorder improve their emotion regulation. Nineteen participants, including those with bipolar disorder and healthy controls, completed behavioral tasks meas…

This pilot study tested whether time-restricted eating (eating only during certain hours) and blue-blocking glasses can help people with bipolar disorder who are experiencing mania. The goal was to see if these approaches are practical and can improve manic symptoms and sleep-wak…

This study tested a new drug, BHV-7000, to see if it can safely and effectively reduce manic symptoms in people with bipolar I disorder. The trial involved 274 adults hospitalized for a manic episode. Researchers measured changes in mania severity over 21 days using a standard ra…

This study tested a non-invasive brain stimulation technique (transcranial electrical stimulation) to reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen adults with mild-to-moderate mania received the treatment, and researchers measured changes in …

This study tested a program called Metacognitive Training (MCT) in 18 adults with schizophrenia, major depression, or bipolar disorder in Taiwan. Over four weeks, participants attended eight group sessions designed to help them recognize and adjust unhelpful thinking patterns. Th…

This study tested four doses of intravenous ketamine in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) over two weeks. The goal was to see if ketamine could safely reduce depression symptoms. Results focused …

This study looked at what happens when people with schizophrenia or bipolar disorder take Igalmi repeatedly for agitation over 7 days, and then stop. Researchers wanted to see if the drug becomes less effective (tolerance) or causes withdrawal symptoms. 29 adults participated in …

This study looked at whether a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) works for veterans who also have serious mental illnesses like schizophrenia or bipolar disorder. 47 veterans took part to see if the therapy was acceptable and helpf…

This study tested whether a smartphone app could passively track activity, sociability, and sleep in 87 veterans with serious mental illnesses like schizophrenia and bipolar disorder. The goal was to see if this data could help detect early warning signs of relapse. The study foc…

This study tested whether sending text message reminders helps young people (ages 14-35) with psychosis attend their first appointment at an early psychosis program after being seen in the emergency room. Researchers enrolled 186 participants and tracked whether they showed up fo…

This pilot study tested a new automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called the system twice a week to share how they were doing, and their providers could listen to the recordings. The goal was to see if this tool co…

This study used brain scans (fMRI) to understand why people with bipolar disorder sometimes have disorganized thoughts and speech. Researchers compared 79 participants—some with bipolar disorder and healthy volunteers—while they performed thinking tasks. The goal was to learn mor…

This study tested a new artificial intelligence tool called CBTpro that helps therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 adults with conditions like schizophrenia, bipolar disorder, or severe depression took part. The goal was t…

This study looked at whether a non-invasive brain stimulation technique called TMS can improve emotion regulation in people with bipolar disorder. Researchers compared how participants performed on tasks involving emotional distractions before and after TMS. The goal was to under…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did brain-training exercises in a room with low oxygen (like high altitude). The goal was to see if this combination improves memory, focus, and problem-solving. Researchers…

This study compared the sense of smell (odor threshold, discrimination, and identification) between 240 people with bipolar disorder and healthy volunteers. Researchers also looked at brain scans to see if smell performance was linked to brain differences. The goal was to better …

This study tested whether a special job support program (IPS-MA) helps people with mood or anxiety disorders return to work or school faster than standard care. 326 adults who were unable to work within three months took part. The program focuses on finding competitive employment…

This early-stage study tested a new oral drug called SEP-380135 in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check if the drug is safe and how the body processes it. Researchers measured side effects, vital signs, and mood…

This study looked at how a gentle brain stimulation technique called TBS affects brain activity and emotions in people with and without bipolar disorder. Researchers wanted to understand the brain mechanisms behind mood swings. 146 adults took part, and the goal was to see if TBS…

This study looked at how alcohol changes brain activity and feelings in young adults with bipolar disorder compared to healthy people. Sixty participants aged 21-26 completed brain scans and surveys after drinking alcohol or a placebo. The goal was to understand why people with b…

This study tested a program called Illness Management and Recovery (IMR) for adults with schizophrenia or bipolar disorder. The goal was to see if the program helps improve daily functioning compared to usual care. 198 people from two community mental health centers in Denmark to…

This study followed 300 pregnant women, some with a history of mood disorders and some without, to understand why some develop depression or other mood problems after giving birth. Researchers collected blood samples and tracked sleep, stress, and other factors to find genetic, h…

This study looked at how the brain chemical glutamate and its receptor mGluR5 are involved in major depression, PTSD, and bipolar disorder. Researchers used MRI and PET scans along with cognitive tests to measure brain activity. The goal was to better understand these conditions,…

This study looked at whether a digital training platform helps clinicians use a mobile health app called FOCUS to support people with serious mental illness like schizophrenia, bipolar disorder, or major depression. About 191 adults used the app and received coaching from trained…

This study tested a telehealth program called CRAFT-EP that helps families support a relative with early psychosis and substance use (like alcohol or cannabis). 65 family members took part. The goal was to see if the program improves family wellbeing, including depression and anx…

This study tested whether alerting police officers that a person has a serious mental illness during a routine check can reduce arrests and help them stay in treatment. About 1,400 adults with conditions like schizophrenia, bipolar disorder, or major depression who had been arres…