BIPOLAR DISORDER

This study tested a behavioral program called CAE-AYA to help teens and young adults with bipolar disorder take their medication more consistently. The program included up to five in-person sessions and a follow-up phone call over eight weeks. Researchers measured adherence using…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested the safety and tolerability of aripiprazole (Abilify) in 21 children and adolescents aged 10 to 17 with schizophrenia or mania. Participants took daily doses of 2 to 30 mg for 14 days. The main goals were to see how many could tolerate the highest dose without s…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

About half of people with bipolar disorder struggle to take their medication as prescribed, which can lead to severe consequences. This study tested a customized program called Customized Adherence Enhancement (CAE) that includes education, motivational interviewing, and help wit…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tested whether adding aripiprazole (Abilify) to the standard mood stabilizer lamotrigine helps prevent relapse in people with bipolar I disorder who recently had a manic or mixed episode. Over 1,100 adults took part, receiving either the combination or lamotrigine alon…

This study tested a culturally adapted psychoeducation program (CaPE) for 303 adults with bipolar disorder in Pakistan who were currently stable. Participants were randomly assigned to receive CaPE plus their usual care or just usual care alone. The goal was to see if CaPE could …

This study looked at whether repeated ketamine infusions can help people with hard-to-treat bipolar depression stay well. 41 adults who had already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if maintenance doses c…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This trial tested a 9-month group program called Illness Management and Recovery (IMR) for 198 adults with schizophrenia or bipolar disorder. The program focused on helping participants set personal goals and manage their symptoms. Researchers measured changes in daily functionin…

This study tested a program called CARE to help people with bipolar disorder stick to their treatment after leaving prison. 34 adults participated in a small pilot trial to see if the program was feasible and acceptable. The goal was to improve symptom control and satisfaction wi…

This study tested a new program called CARE to help people with bipolar disorder stick with their treatment after leaving prison. 18 adults participated to see if the program was practical and helpful. The goal was to improve mood stability and reduce symptoms.

This study tested whether a very low-carbohydrate ketogenic diet could improve brain network stability and thinking skills in people with schizophrenia or bipolar disorder. The diet is high in fat and low in carbs, which makes the body produce ketones that may provide extra energ…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This study tested whether a new drug called BHV-7000 can safely and effectively treat manic episodes in people with bipolar I disorder. 274 hospitalized adults took either the drug or a placebo once daily for 21 days. The main goal was to see if the drug reduced mania symptoms, m…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This completed trial tested a special support program for veterans with both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 participants received the program, while the other half got enhanced safety monitoring. The goal was to see if t…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested a new way to use repetitive transcranial magnetic stimulation (rTMS) to treat depressive episodes in 40 adolescents with bipolar disorder. Instead of the usual front-brain target, researchers stimulated the visual cortex at the back of the brain, aiming to affec…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive function in 82 people with stable bipolar disorder. Participants received task-activated rTMS while doing cognitive training. Th…

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested whether taking probiotics (good bacteria) can reduce depressive symptoms in people with bipolar disorder. 141 adults were randomly assigned to receive either probiotics or a placebo for 12 weeks. The goal was to see if probiotics could improve mood and reduce de…

This study tested whether extra psychoeducational nursing sessions could improve quality of life, emotional well-being, and reduce anxiety in 120 adults receiving modified electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. Half the patients got th…

This study tested a structured psychiatric nursing program for family caregivers of people with bipolar disorder. The program included education, stress management, and emotional support. Researchers measured changes in caregiver burden, resilience, and emotional well-being over …

This study tested a behavioral therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and other daily rhythms to reduce short-te…

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abili…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This study tested whether a smartphone app called FOCUS, along with coaching from trained clinicians, could help people with serious mental illnesses like schizophrenia and bipolar disorder. 191 participants used the app and received coaching over 12 weeks. Researchers measured c…

This phase 2 trial tested four intravenous ketamine infusions over two weeks in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) to see if ketamine could quickly reduce depression symptoms. The study measured c…

This study tested whether a dynamic LED-light system that changes brightness and color throughout the day could improve depression symptoms in hospitalized patients. 60 adults with major depression were randomly assigned to either a room with the special lighting or standard ligh…

This pilot study tested whether time-restricted eating and blue-blocking glasses can help people with bipolar disorder during manic episodes. The goal was to see if these simple, drug-free approaches are feasible and safe for inpatients. Twenty-one participants were enrolled to t…

This completed Phase 4 study tested valbenazine in 59 adults with tardive dyskinesia (involuntary muscle movements) caused by psychiatric medications. Participants had schizophrenia, bipolar disorder, or major depression. Over 24 weeks, researchers measured changes in quality of …

This small pilot study tested whether a ketone ester drink combined with a low-glycemic diet could help people with bipolar disorder. Fifteen adults with bipolar I or II took the supplement twice daily and made simple diet changes for several weeks. Researchers measured blood ket…

This study tested a group therapy program called Metacognitive Training (MCT) in 18 Taiwanese adults with schizophrenia, major depression, or bipolar disorder. Over 4 weeks, participants attended 8 sessions that taught them to spot and reduce thinking biases linked to symptoms li…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills in 62 people with depression, bipolar disorder, or psychotic disorders like schizophrenia. Participants practiced daily-life tasks in VR, such as cooking and shopping, guided by…

This study tested a non-invasive brain stimulation technique to reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen participants with mild-to-moderate mania received targeted electrical stimulation to brain areas linked to impulse control and risk-t…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did cognitive training inside a room with low oxygen (like being at 4,400 meters altitude). The goal was to see if the combination improves memory, attention, and executive …

This study looked at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illnesses like schizophrenia or bipolar disorder manage chronic pain. 47 veterans took part in a 12-session CBT program designed for chronic pain. The goal was to see if the ther…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This study tested whether sending text message reminders and support to young people with psychosis after an emergency room visit helps them attend their first early psychosis appointment. 186 participants were enrolled. The goal was to see if a low-cost, youth-friendly approach …

This study tested whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, could improve emotion regulation in people with bipolar disorder. Fifty-six participants, including healthy controls, underwent brain scans while performing tasks design…

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder regulate their emotions. Nineteen participants, including healthy controls, completed behavioral tasks measuring…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study used functional MRI to look at brain activity in people with bipolar disorder while they performed tasks involving language and meaning. The goal was to better understand why some patients experience disorganized thinking or speech. 79 participants took part, including…

This study used a non-invasive brain stimulation technique called theta burst stimulation (TMS) to explore how the brain processes rewards in people with bipolar disorder. Researchers compared brain scans before and after stimulation in 146 adults, both with and without bipolar d…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study looked at how young adults with bipolar disorder respond to alcohol compared to healthy people. Sixty participants aged 21-26 completed brain scans and surveys after drinking alcohol or a placebo. The goal was to understand differences in brain activity and feelings of…

This study tested whether a smartphone app could help veterans with serious mental illnesses like schizophrenia and bipolar disorder track their own symptoms. 87 veterans used the app to monitor their activity, sleep, and social interactions. The goal was to see if this data coul…

This study tested whether group-based education classes for relatives of people with bipolar disorder could improve their mood stability and reduce stress. About 200 relatives participated, with half attending classes and half placed on a waiting list. The goal was to see if lear…

This study tested a system where police officers can call a mental health provider during encounters with people who have serious mental illness. The goal was to see if this reduces arrests and helps people stay connected to care. Over 1,400 participants were randomly assigned to…

This completed study compared smell abilities and brain scans between 240 people with bipolar disorder and healthy volunteers. Researchers tested odor threshold, discrimination, and identification to see if smell performance differs and relates to brain structure. The goal is to …