BIPOLAR DISORDER

This study tested whether regular ketamine infusions could help maintain relief from severe bipolar depression in people who initially responded to the treatment. Forty-one adults with treatment-resistant bipolar depression received flexible-dose ketamine infusions every 2-4 week…

This study tested whether a special job support program could help people with depression or anxiety return to work or school. 326 adults who were unable to work due to their condition received either the job coaching plus their usual treatment, or just their usual treatment. Res…

This study tested a new support program designed to help people with both bipolar disorder and a substance use problem stay on their treatment plan after leaving the hospital. Researchers compared a specialized counseling program against a standard safety check-in program, both a…

This study tested whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression. 71 participants who hadn't responded to standard medications received either ketamine or a sedative placebo over two weeks. Researchers measured changes i…

This small pilot study tested a new support program for people with bipolar disorder who were leaving prison. The CARE program provided counseling and phone check-ins to help participants connect with mental health treatment and manage their symptoms during the difficult transiti…

This small, exploratory study tested whether a ketone supplement combined with a low-sugar diet could help people with bipolar disorder. Researchers enrolled 15 participants to see if this approach could improve mood stability and brain function. The main goal was to gather initi…

This small pilot study tested a new support program for people with bipolar disorder who were leaving prison and returning to the community. The program combined counseling sessions and follow-up phone calls to help participants stick with their mental health treatment and manage…

This study tested whether a very low-carbohydrate, high-fat ketogenic diet could improve brain network stability in people with schizophrenia or bipolar disorder. Researchers enrolled 71 adults and compared those on the special diet for four weeks to those eating as usual. The go…

This study tested if sending supportive text messages could help young people with psychosis get from the emergency room to their first follow-up appointment. Researchers enrolled 186 young adults (ages 16-29) to see if reminders and check-ins via text improved attendance at that…

This study tested whether a special three-week program could improve thinking skills. Participants, including healthy adults and people with stable depression or bipolar disorder, spent time in a room with low oxygen levels (like being at high altitude) while doing brain-training…

This study tested a structured program designed to help people with schizophrenia or bipolar disorder learn skills to better manage their condition. It compared the program to regular care for about 200 adults in Denmark. The main goal was to see if the program improved participa…

This study tested a new system designed to help people with serious mental illnesses avoid unnecessary arrests and stay connected to treatment. When police ran a routine check during an encounter, half the participants triggered a message alerting the officer to call a mental hea…

This study tested a new support program designed to help veterans who have both bipolar disorder and a substance use problem after they leave the hospital. It compared a special counseling program against a basic safety check-in program, both added to their regular care. The goal…

This small pilot study explored whether two non-drug therapies could help people hospitalized for manic episodes of bipolar disorder. Researchers tested if restricting eating to a 10-hour daytime window and/or wearing glasses that block blue light could improve manic symptoms and…

This study tested a family training program delivered by video call. It aimed to help family members support a relative who is experiencing early psychosis and using substances like alcohol or cannabis. The goal was to see if the program improved family wellbeing and helped the r…

This study tested whether an investigational drug called BHV-7000 is safe and effective for quickly reducing symptoms of a manic episode in people hospitalized with Bipolar I Disorder. Over 270 adult participants received either the drug or a placebo (inactive substance) for 21 d…

This study tested whether a smartphone app designed specifically for people with serious mental illness could help them quit smoking better than standard advice. Over 300 participants with conditions like schizophrenia, bipolar disorder, or depression were randomly assigned to us…

This Yale University study tested a new therapy designed to prevent suicide in adolescents and young adults with depression or bipolar disorder. The therapy teaches self-help strategies to create more regular daily routines, especially for sleep, with the goal of improving brain …

This study tested whether a special group training program could help people with schizophrenia, major depression, or bipolar disorder. The program, called Metacognitive Training, taught participants new ways of thinking over eight sessions. Researchers measured changes in sympto…

This study tested whether a talk therapy program for chronic pain is practical and helpful for veterans who also have serious mental illnesses like schizophrenia or bipolar disorder. Researchers worked with 47 veterans to see if they could successfully participate in the therapy …

This study tested whether the drug valbenazine could improve daily life for people with tardive dyskinesia (TD), a condition causing uncontrollable movements often linked to certain mental health medications. For 24 weeks, 59 adults with TD and conditions like schizophrenia or bi…

This study tested a non-invasive brain stimulation technique to see if it could help reduce depressive episodes in adolescents and young adults with bipolar disorder. Researchers used a method called repetitive transcranial magnetic stimulation (rTMS), guided by brain imaging, to…

This study tested whether group education classes for family members of people with bipolar disorder could help improve the relatives' own mood stability and reduce their stress. About 200 relatives were randomly assigned to either take the classes right away or wait four months.…

This study tested whether a gentle, non-invasive brain stimulation technique could reduce cravings in people struggling with both substance use and another mental health condition like ADHD or bipolar disorder. Researchers targeted a specific brain area linked to craving using a …

This study tested whether a 4-week virtual reality (VR) brain training program could improve thinking skills and daily functioning in people with stable depression, bipolar disorder, or schizophrenia. 62 participants were randomly assigned to receive either the active VR cognitiv…

This study looked at what happens when people with schizophrenia or bipolar disorder stop taking a short-term medication for agitation. Researchers gave 29 adults the drug Igalmi as needed for 7 days to calm agitation episodes, then monitored them for 3 days after stopping. The m…

This study tested whether a personalized, non-invasive form of brain stimulation could help reduce symptoms of mania in people with bipolar or schizoaffective disorder. Fourteen participants with mild to moderate manic symptoms received stimulation targeted at a specific brain ar…

This study aimed to understand why people with bipolar disorder are at much higher risk for alcohol problems. Researchers gave alcohol or a placebo drink to 60 young adults (half with bipolar disorder, half healthy) and used brain scans and surveys to measure how they felt and ho…

This study tested a new AI-powered computer program called CBTpro, designed to help therapists learn and practice a specific talk therapy for people with psychosis. The tool listens to therapists practice with simulated patients and gives them feedback to improve their skills. Re…

This small pilot study tested a new phone system called 'My Coach Connect' to see if it could help communication between patients and their mental health providers. Patients with conditions like depression or schizophrenia called in twice a week for four months to leave voice mes…

This study aimed to understand if there is a link between a person's sense of smell and bipolar disorder. Researchers compared smell test results and brain scans from 240 people with bipolar disorder to healthy volunteers. The goal was to gather information to help understand the…

This study aimed to better understand how bipolar disorder affects a person's thought and speech patterns, such as racing thoughts or losing track of ideas. Researchers used brain scans (fMRI) to compare the brain activity of 79 people, including those with bipolar disorder and h…

This study aimed to understand how brain chemistry differs in people with depression, PTSD, and bipolar disorder. Researchers used MRI and PET brain scans and cognitive tests on 180 participants, including healthy volunteers, to measure specific brain chemicals. The goal was to g…

This study aimed to understand if a non-invasive brain stimulation technique called TMS could help people with bipolar disorder better control their emotions. Researchers compared brain scans of 30 healthy people and 30 people with bipolar disorder while they performed emotion-re…

This study aimed to understand what causes mood episodes like depression after childbirth. Researchers followed 300 pregnant women, some with and some without a history of mood disorders, to track their mental health. They collected information on genes, hormones, stress, and sle…

This study tested a smartphone app designed to help veterans with serious mental health conditions track their own well-being. The app passively collects data on phone use, movement, and sleep patterns, which may act as warning signs for worsening symptoms. Researchers aimed to s…

This small, completed study explored whether a non-invasive brain stimulation technique called TMS could help people with bipolar disorder regulate their emotions better. Researchers tested 19 participants to see if stimulating specific brain areas improved their performance on e…

This study aimed to understand the brain mechanisms behind bipolar disorder. Researchers used a safe, non-invasive brain stimulation technique while participants played a reward-based game inside an MRI scanner. They compared brain activity in 146 adults with and without bipolar …