Brain training shows promise for bipolar thinking problems

NCT ID NCT01470781

Completed Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abilities and daily functioning compared to a control group. The goal was to see if this brain training could help with the thinking problems that often come with bipolar disorder.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BrainWorks computer-based cognitive training program
What this could lead to: If it works, this could point toward a non-drug way to sharpen memory, attention, and problem-solving skills in people with bipolar disorder.
What could go wrong: This is a small, completed study with only 72 participants, so results may not apply to everyone. The training is time-consuming and may not improve real-world functioning.

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Conditions

The condition(s) this trial relates to.

bipolar disorder psychotic disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER PSYCHOSIS

Contacts and locations

Locations

McLean Hospital

Belmont, Massachusetts, 02478, United States

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