PSYCHOSIS

This study tests whether a personalized care plan can help young people (ages 15-30) with early psychosis function better in daily life. The plan combines brain-training exercises, nutritional supplements, and educational guidance tailored to each person's needs. The goal is to i…

This pilot study tests a structured program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education, one-on-one peer support, and guidance for community healthcare providers. The g…

This study tests whether a type of talk therapy called Mentalization-Based Treatment (MBT) can help young people at high risk for psychosis avoid developing the condition. Researchers will compare MBT plus standard care to standard care alone in 212 participants aged 14-30. The g…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard coordinated specialty care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanc…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alongside their usual care. T…

This study tests whether a new combination drug, KarXT + KarX-EC, can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 325 adults aged 55 to 90 with Alzheimer's and psychosis will receive either the drug or a placebo. The goal is to see if the …

This study tests whether a brief, virtual cognitive remediation therapy (called Action-Based Cognitive Remediation) can help young people aged 16-30 with early psychosis reduce their alcohol and cannabis use. The therapy involves 16 sessions over 2 months, focusing on improving t…

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The goal is to see if the app is …

This study tests whether breathing extra oxygen (normobaric oxygen therapy) can improve thinking, quality of life, and daily functioning in people who have had psychosis for less than five years. Twenty participants aged 15–35 will receive either oxygen or a placebo air treatment…

This study looks at whether the hormone estradiol can help perimenopausal women who started having depression, psychosis, or loss of interest in rewards during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use brain s…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses brain exercises to improve how the brain processes information, with the goal of boosting thinking skills and dai…

This study looks at how high-potency cannabis affects the brain's white matter in young adults (ages 18-25) with early psychosis. Participants will take metformin daily for 6 months and undergo brain scans and questionnaires. The goal is to see if this approach is feasible for a …

This study explores whether precise brain stimulation can lower cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a type of magnetic stimulation (rTMS) on specific brain areas and measure changes in cravings and brain activity. The g…

This study looks at language difficulties in people with psychosis, including those with schizophrenia or early warning signs. Researchers will give language tests to 90 patients and compare results with healthy controls. The goal is to understand how language problems connect wi…

This study looks at how the immune system might influence psychotic symptoms and how well antipsychotic medications work. Researchers will collect blood and spinal fluid from 500 people with psychosis who are starting or changing medication, plus a healthy comparison group. The g…

This study looks at how feeling lonely and being socially isolated affect the brains of people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these links. The goal is to find new ways to he…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, can weaken the immune system over time. Researchers will measure immune cells and antibodies in 24 patients before and after 6 months and 1 year of treatment. The goal is to understand i…

This study looks at how a brain chemical called glutamate relates to memory and attention in people who have recently had psychosis. Researchers will use brain scans and a gentle electrical stimulation technique to see if glutamate levels can predict who might benefit from this t…

This study looks at whether a non-invasive brain stimulation technique called TMS can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve problems. About 95 participants will do thinking tasks and get brain scans before and after TMS…

This study is testing a new blood test to see if it can help doctors tell the difference between depression and schizophrenia, and predict which treatments will work best. Researchers will collect blood samples and mental health surveys from 500 adults over three visits. The goal…

This study looks at why teens with autism or schizophrenia struggle with social interactions. Researchers will use brain scans to see how a 16-week social skills program changes brain activity and connections. The goal is to find out what brain differences are shared or unique be…

This study tests a 10-week, at-home program called SCORES that uses computer exercises and group support to boost processing speed—how quickly the brain handles information—in 54 teens at high risk for psychosis. The goal is to see if faster thinking leads to better social skills…

This study looks at 200 people with schizophrenia who are starting clozapine, a medication for tough-to-treat cases. Researchers will check brain scans, spinal fluid, and blood before and after 12 weeks of treatment to find markers that show why clozapine works. The goal is to le…