PSYCHOSIS

This study is testing a 10-week online brain training program called SCORES for adolescents showing early warning signs of psychosis. The program combines thinking speed exercises with group support, aiming to improve social skills and potentially reduce the risk of developing fu…

This study is testing if a non-invasive brain stimulation technique can reduce cravings for cannabis in people with schizophrenia. Researchers believe the brains of people with schizophrenia may be wired differently, making them more vulnerable to cannabis use. They will use targ…

This study is testing whether adding five extra support elements to standard early psychosis care helps young adults stay engaged in treatment. The enhanced program includes peer support, family therapy, digital outreach, care coordination, and cognitive training. Researchers wil…

This study is testing if following a ketogenic diet (high-fat, very low-carb) alongside usual treatment can help people recently diagnosed with bipolar disorder or schizoaffective disorder. Researchers will measure if the diet changes how the brain uses energy and if it improves …

This small pilot study is testing whether a new support program can help young adults with bipolar disorder stay healthier after leaving the hospital. The program combines group education, one-on-one peer support, and guidance for community doctors. Researchers want to see if thi…

This study is testing whether a new blood test can help doctors better diagnose depression and schizophrenia. Researchers will follow 500 participants with these conditions to see if the blood test can distinguish between different diagnoses and predict who will respond to treatm…

This study is testing whether a specialized talk therapy, called Mentalization-Based Treatment, can help prevent or delay the onset of full psychosis in young people who show early warning signs. It will compare the therapy plus standard care against standard care alone in 212 pa…

This study is testing whether a smartphone app called Kiso Mind is helpful and easy to use for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app alongside their usual care or receive only their usual care for 12 weeks. Researcher…

This small pilot study is testing whether breathing slightly enriched oxygen at night can help young people experiencing their first episode of psychosis. For 4 weeks, participants will use a nasal tube connected to a machine that delivers either regular room air or air with extr…

This small pilot study is testing if a single ketone drink can improve symptoms for people with schizophrenia or bipolar disorder. Researchers will compare the ketone drink to a similar-tasting carbohydrate drink in 24 participants. The main goal is to see if the drink improves h…

This study is testing a computer-based brain training program for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to see if this training can improve thinking skills, reduce symptoms, and help with daily life activities. Researche…

This pilot study is testing whether adults experiencing acute mental health crises like severe anxiety, depression, or psychosis can safely receive hospital-level care at home instead of in a traditional hospital. Researchers will enroll 45 carefully screened, lower-risk patients…

This study aims to understand if a non-invasive magnetic brain stimulation technique can change how quickly people with psychotic disorders think and solve problems. Participants with schizophrenia, bipolar disorder, or schizoaffective disorder will perform thinking tasks and hav…

This study aims to understand how pregnancy and breastfeeding affect long-acting injectable antipsychotic medications used for conditions like schizophrenia. Researchers will measure drug levels in the blood of pregnant and breastfeeding women, and also check how much of the medi…

This study aims to understand how a 16-week social skills training program affects the brain in teenagers with autism or schizophrenia. Researchers will use MRI brain scans before and after the training to see if brain connections and chemistry change. They will compare these tee…

This study aims to understand if the Parkinson's psychosis medication clozapine affects the body's immune system over time. Researchers will follow 24 Parkinson's patients taking clozapine, measuring their antibody levels and immune cells at 6 months and 1 year. The goal is to ga…

This study aims to understand how the body's immune system influences psychosis symptoms and how people respond to antipsychotic medications. Researchers will collect blood and spinal fluid samples from 500 people with psychosis symptoms who are starting or changing medications, …

This study aims to find biological markers that can predict which patients with hard-to-treat schizophrenia will benefit from the medication clozapine. Researchers will examine 200 patients before and after 12 weeks of clozapine treatment, looking at immune markers in blood and s…