Brain scans reveal what happens when cannabis users with psychosis go cold turkey

NCT ID NCT05445180

Recruiting now Knowledge-focused Sponsor: Douglas Mental Health University Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the 28-day period. The goal is to understand the brain processes behind cannabis-related thinking problems, which could lead to better treatments.

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Conditions

The condition(s) this trial relates to.

cannabis dependence cognitive disorder Cognitive Dysfunction Memory Disorders psychotic disorder Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS DEPENDENCE CANNABIS USE CANNABIS USE DISORDER COGNITIVE DYSFUNCTION MEMORY IMPAIRMENT NEUROIMAGING PSYCHOTIC DISORDERS SCHIZOPHRENIA; PSYCHOSIS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Douglas Mental Health University Institute
RECRUITING

Montreal, Quebec, H4H 1R3, Canada

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••