CANNABIS USE DISORDER

This study tests whether hemp-derived CBD (with or without a tiny amount of THC) can help people who use cannabis concentrates regularly to cut down or stop. 165 adults who want to reduce their cannabis use will take either CBD or a placebo for 8 weeks, plus attend therapy. Resea…

This study tests whether semaglutide (Wegovy), a drug used for weight loss, can help adults with cannabis use disorder use less cannabis. 100 participants will receive either semaglutide or a placebo injection weekly for 20 weeks. The main goal is to see if the drug reduces total…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study tests whether hemp-derived CBD can reduce the harmful effects of cannabis in young adults aged 18-25 who use cannabis at least five days a week but aren't looking to quit. Participants will take either CBD or a placebo for 8 weeks, and researchers will measure changes …

This study tests whether cannabidiol (CBD), a non-psychoactive compound from cannabis, can reduce cannabis concentrate use and cravings in people who use concentrates regularly but aren't trying to stop. 120 participants will take either 200 mg or 400 mg of CBD or a placebo daily…

This pilot study is testing whether a noninvasive brain stimulation device, used at home along with guided mindfulness, can help people with cannabis use disorder reduce their use. Forty-six adults who want to cut back on cannabis will receive either real or sham stimulation over…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study tests a new type of brain stimulation (rTMS) as a treatment for cannabis use disorder. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is safe, tolerable, and can reduce cravings and use.

This study looks at what happens when adults with cannabis use disorder cut back on cannabis. Over 8 weeks, participants get counseling, computer-based therapy, and small rewards for reducing use. The goal is to see if cutting back leads to fewer cannabis-related problems, better…

This pilot study at Johns Hopkins University is testing whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder. Twelve adults will receive two doses of psilocybin along with counseling over 12 weeks. Researchers will track cannabi…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study looks at how cannabis use and stress affect each other in young adults aged 18-25 with cannabis use disorder. Researchers will test whether a single dose of cannabidiol (CBD) can reduce withdrawal symptoms and stress, and delay the urge to use cannabis again. The goal …

This study tests a brief computerized and smartphone-based program designed to help regular cannabis users with Cannabis Use Disorder better handle emotional stress. The goal is to see if the intervention reduces distress intolerance and cannabis use compared to a health educatio…

This study tests a smartphone-based program called RISE Guide for women who have just been sexually assaulted. The goal is to see if it can reduce anxiety sensitivity and prevent posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD). 68 women who seek emergency car…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study compares two brief behavioral interventions for emerging adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions a week apart and are followed for 6 months. The goal is to see if either program helps red…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study is testing whether 12 weeks of group cognitive behavioral therapy (CBT) can help people reduce their alcohol or cannabis use. Researchers will enroll 400 adults with alcohol use disorder or cannabis use disorder. Participants will attend weekly CBT sessions, and the st…

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…

This study is testing whether simple saliva tests done at home can accurately show when someone has not used cannabis. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples over 3-4 weeks, and resea…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study looks at how a single session of exercise changes blood markers related to brain health in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other substances in the blood, along with cognitive tests. The goal i…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how the brains of teens (ages 15-18) with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use MRI scans to measure brain activity related to reward and impulse control. Some teens will be paid to stay cannabis-free, whi…

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study gives people with Cannabis Use Disorder drugs that mimic stress to see how it affects their desire for cannabis. Researchers measure brain activity and decision-making during four lab visits. The goal is to understand the link between stress and cannabis use motivation…