CANNABIS USE DISORDER

This study is testing whether varenicline (Chantix), a medication approved for quitting smoking, can also help people reduce or stop using cannabis. Researchers will compare the medication against a placebo pill in 200 adults in South Carolina who use both cigarettes and marijuan…

This study is testing whether a non-invasive brain stimulation technique can help people with cannabis use disorder reduce their use and cravings. Researchers will use a magnetic coil placed on the scalp to target brain areas involved in addiction. The 4-week trial will assess if…

This study is testing whether helping adults with cannabis use disorder reduce their cannabis use leads to improvements in their daily lives. 176 participants will receive 8 weeks of counseling, online therapy, and small rewards for reducing use. Researchers will measure changes …

This study is testing a smartphone app designed to help people who are dealing with both depression and frequent cannabis use. The app focuses on increasing positive feelings and motivation. Researchers will compare the app to simple symptom tracking to see if it helps reduce dep…

This study is testing two different talk therapy programs to help teens and young adults (ages 14-21) who struggle with alcohol or drug use. Researchers want to see if adding 12-step program support to standard therapy works better than standard therapy alone. The study will foll…

This small pilot study is exploring whether psilocybin, the active compound in 'magic mushrooms,' combined with therapy, can help people reduce or stop problematic cannabis use. Twelve adults with cannabis use disorder will receive two guided psilocybin sessions along with counse…

This study is testing a smartphone-based therapy app designed to prevent post-traumatic stress disorder (PTSD) and problematic cannabis use in women who have recently experienced sexual assault. The app focuses on reducing anxiety sensitivity, a known risk factor for these condit…

This study is testing whether a home-based treatment using gentle brain stimulation (tDCS) combined with mindfulness meditation can help adults reduce or quit cannabis use. Researchers will enroll 46 people with cannabis addiction to try the one-month program and track their crav…

This study is testing a brief, computerized program delivered via smartphone to help people with cannabis use disorder manage stress better. Researchers want to see if learning to tolerate distress through this program can reduce stress-related cannabis use and improve overall we…

This early-stage study is testing whether a new AI chatbot, called Therabot-CALM, is easy to use and acceptable for people who have cannabis use disorder along with anxiety or depression. The main goal is to see if people find the app helpful and user-friendly, not to prove it tr…

This study aims to see if brain scans can predict how well teens respond to a cannabis treatment program. Researchers will scan the brains of 80 teens (ages 14-17) who use cannabis, then have them join 10 weeks of virtual sessions where they report use and take drug tests. Teens …

This Yale University study aims to understand how the brain changes when people with cannabis use disorder stop using it for at least four weeks. Researchers will use brain scans and memory tests to see if brain connections linked to memory improve during abstinence. The study co…

This study aims to understand why some people respond better to therapy for alcohol or cannabis addiction than others. Researchers will enroll 400 adults with these disorders, give them detailed brain function tests, and then provide 12 weeks of standard therapy. The main goal is…

This study aims to understand how brain connections differ in people with schizophrenia or cannabis use disorder compared to healthy people. Researchers will use a special brain scan (PET imaging) to measure these connections in 250 adults aged 18-65. The goal is to gather knowle…

This study aims to understand how stress and cannabis withdrawal affect young men and women differently. Researchers will observe 148 young adults with frequent cannabis use as they temporarily stop using it and undergo a controlled stress test. The goal is to gather information …

This study is testing if an FDA-approved insomnia medication called suvorexant (BELSOMRA) changes brain activity in people who use cannabis frequently. Researchers want to see if the drug reduces activity in brain areas linked to cannabis cravings. Twenty participants will take t…

This study aims to understand how stress affects the brain's response to cannabis cues and increases cravings in people with cannabis use disorder. Researchers will give 36 participants different drug combinations that mimic stress responses and measure brain activity, blood mark…

This study aims to see if at-home saliva tests can reliably measure cannabis use in remote clinical trials. Researchers will recruit 200 young adults who use cannabis weekly to compare saliva test results with urine tests and self-reported use. The goal is to find easier, remote-…