CANNABIS USE DISORDER

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder cut back or stop using cannabis. Twelve adults will receive two psilocybin sessions with psychological support and be followed for 6 months. The g…

This study tests a new therapy called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines two proven approaches—12-step support and motivational therapy—to see if it helps teens stay abstinent longer and reduce substance-related problems. About 294 par…

This study tests a new type of brain stimulation (rTMS) to help people with cannabis use disorder reduce or stop using cannabis. About 46 adults who use cannabis frequently and want to cut back will receive 4 weeks of treatment. The goal is to see if the treatment is safe, tolera…

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will receive either the drug or a placebo, plus counseling and online tools. The goal is to see if the medication imp…

This study looks at what happens when adults with cannabis use disorder cut back on cannabis. Over 8 weeks, participants get counseling, computer-based therapy, and financial rewards for reducing use. Researchers will track changes in sleep, thinking, cannabis-related problems, a…

This study aims to help people who use cannabis daily and have trouble handling stress. Researchers will test a one-session computer program plus smartphone reminders to see if it reduces stress-related cannabis use. About 80 adults with Cannabis Use Disorder will participate, an…

This study tests whether cannabidiol (CBD) can help people who regularly use high-potency cannabis concentrates reduce their use and cravings. About 120 adults aged 25-60 who use concentrates at least 4 times a week but aren't trying to quit will take CBD (200 or 400 mg daily) or…

This study tests whether hemp-derived CBD can help young adults (ages 18-25) who use cannabis at least 5 days a week reduce their cannabis use and related harm. Participants are not trying to quit and will take either CBD or a placebo for 8 weeks. The study measures changes in ca…

This study tests a digital program designed to prevent posttraumatic stress disorder (PTSD) and cannabis use disorder in women who have been sexually assaulted. The program targets anxiety sensitivity, a known risk factor. Researchers will enroll 68 women who come to the emergenc…

This study tests whether a brief, virtual cognitive remediation therapy (called Action-Based Cognitive Remediation) can help young people aged 16-30 with early psychosis reduce their alcohol and cannabis use. The therapy involves 16 sessions over 2 months, focusing on improving t…

This early-stage study is testing a generative AI chatbot called Therabot-CALM to see if it is acceptable and helpful for people who have cannabis use disorder along with anxiety or depression. Fifteen participants will use the app for four weeks and give feedback through intervi…

This study compares two brief counseling programs for young adults aged 18-25 who use cannabis frequently (20+ days per month). Participants attend two 40-50 minute sessions a week apart and complete follow-ups over 6 months. The goal is to see which program better reduces cannab…

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app improves mood, reduces cannabis use, and is easy to use.

This study tests a one-month program where 46 adults with cannabis use disorder do 20 sessions of home-based brain stimulation (tDCS) while listening to guided mindfulness meditation. Half get real stimulation, half get a sham version. Researchers will check if the treatment is s…

This study looks at whether stopping cannabis for at least 4 weeks can improve brain cell connections in people with cannabis use disorder. Researchers will use brain scans to measure these connections and test memory before and after quitting. The study involves 51 participants,…

This study looks at how cannabis use and stress interact differently in young men and women aged 18-25 who have cannabis use disorder. Researchers will measure withdrawal symptoms, stress reactions, and how soon people start using cannabis again after a short break. The goal is t…

This study looks at how the brains of teens aged 15–18 with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use brain scans to measure reward and impulse control, and compare them to teens who never used cannabis. The goal is to better und…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will use brain scans to measure changes in brain chemicals and activity related to reward. The goal is to understand these differen…

This study looks at how stress and pain affect hormones and mood in 120 people with or without HIV, cannabis use disorder, and depression. Participants will do a pain stress task and give blood samples to measure stress chemicals. The goal is to understand these connections, not …

This study looks at whether suvorexant, a drug approved for insomnia, can reduce brain activity linked to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug lowers the brai…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 will have a brain scan and then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study is testing whether a saliva (spit) test can accurately show if someone has used cannabis in the past few days, all done from home. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will collect their own saliva samples at…

This study is for 400 adults with alcohol or cannabis use disorder who are willing to try group therapy. Researchers will measure thinking skills, motivation, and emotions before and during 12 weeks of cognitive behavioral therapy. The goal is to see how these brain functions rel…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers aim to understand how these con…

This study looks at how stress influences the urge to use cannabis in people with Cannabis Use Disorder. Researchers will give participants drugs that mimic stress and measure their brain activity, choices, and blood levels of natural cannabinoids. The goal is to understand the c…