New pill aims to take the edge off quitting weed

NCT ID NCT07644052

Recruiting now Symptom relief Sponsor: PleoPharma, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 12 times

Summary

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay at the start. The goal is to see if PP-01 reduces symptoms like irritability and sleep trouble better than placebo or nabilone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PP-01 (a combination product that partially activates cannabinoid receptors and modulates GABA)
What this could lead to: If successful, this could provide a new medication to help people quit cannabis by reducing withdrawal symptoms like irritability and sleep problems.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not work better than placebo or existing treatments, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence substance withdrawal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS WITHDRAWAL

Contacts and locations

Locations

AMR Clinical
RECRUITING

Lexington, Kentucky, 40509, United States
AMR Clinical
RECRUITING

Knoxville, Tennessee, 37920, United States
CenExel iResearch, LLC
RECRUITING

Savannah, Georgia, 31405, United States
Coastal Carolina Research Center, LLC
RECRUITING

North Charleston, South Carolina, 29405, United States
Community Clinical Research, Inc.
RECRUITING

Austin, Texas, 78754, United States
Evergreen Clinical Trials
RECRUITING

Norcross, Georgia, 30092, United States
ForCare Clinical Research
RECRUITING

Tampa, Florida, 33613, United States
Hassman Research Institute, LLC d/b/a CenExel Marlton, NJ
RECRUITING

Marlton, New Jersey, 08053, United States
Maryland Psychiatric Research Center, University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21228, United States
Memorial Hermann Village
RECRUITING

Houston, Texas, 77043, United States
Neuro-Behavioral Clinical Research, Inc.
RECRUITING

North Canton, Ohio, 44720, United States
Neuroscience Research Institute
RECRUITING

West Palm Beach, Florida, 33407, United States
Oasis Clinical Research
RECRUITING

Las Vegas, Nevada, 89121, United States
Research Centers of America
RECRUITING

Hollywood, Florida, 33024, United States
Richmond Behavioral Associates
RECRUITING

Staten Island, New York, 10314, United States
Sandhill Research, LLC d/b/a Accel Research Sites - NeuroStudies Clinical Research Unit 755
RECRUITING

Decatur, Georgia, 30030, United States
Sandhill Research, LLC d/b/a Accel Research Sites - St. Pete - Largo Clinical Research Unit
RECRUITING

Largo, Florida, 33777, United States
The Research Foundation for Mental Hygiene/ New York State Psychiatric Institute
RECRUITING

New York, New York, 10032, United States
University Clinical Research-DeLand, LLC d/b/a Accel Research Sites - DeLand Clinical Research Unit
RECRUITING

DeLand, Florida, 32720, United States
Woodland International Research Group, LLC
RECRUITING

Little Rock, Arkansas, 72211, United States
Woodland Research Northwest, LLC
RECRUITING

Rogers, Arkansas, 72758, United States
Yale Stress Center
RECRUITING

New Haven, Connecticut, 06519, United States

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