Genes may determine who gets hooked or psychotic from cannabis

NCT ID NCT06058702

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Researchers measure changes in mood, perception, thinking, and symptoms to see if certain genes predict stronger reactions. The goal is to better understand why some people develop cannabis use disorder or schizophrenia-related symptoms after using cannabis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Delta-9-THC (active ingredient in cannabis) given intravenously at very low and medium doses, compared to placebo
What this could lead to: If successful, this research could help identify genetic factors that make some people more vulnerable to cannabis addiction or psychosis, potentially guiding personalized prevention or treatment strategies.
What could go wrong: This is an early-phase study with a small sample, so findings may not apply broadly. The genetic links are complex and may not lead to clear clinical applications.

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Conditions

The condition(s) this trial relates to.

cannabis dependence schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE DISORDER SCHIZOPHRENIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

West Haven Veterans Affairs Medical Center
RECRUITING

West Haven, Connecticut, 06516, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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