Brain scans reveal sex differences in THC effects for cannabis users
NCT ID NCT07225777
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goal is to understand sex-specific brain responses, which could lead to more tailored treatments in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dronabinol (synthetic THC)
What this could lead to
If it works, this could point toward personalized treatments for cannabis use disorder based on sex differences.
What could go wrong
This is a small early-phase study with only 40 participants, so results may not apply to everyone. It is designed to understand brain mechanisms, not to test a new treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29403, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••