Stress pills may reveal why you crave cannabis

NCT ID NCT06430580

Recruiting now Knowledge-focused Sponsor: Florida State University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study gives people with Cannabis Use Disorder drugs that mimic stress to see how it affects their desire for cannabis. Researchers measure brain activity and decision-making during four lab visits. The goal is to understand the link between stress and cannabis use motivation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hydrocortisone and Yohimbine Hydrochloride
What this could lead to: If successful, this could help explain how stress triggers cannabis cravings, pointing toward better treatments for Cannabis Use Disorder.
What could go wrong: This is a very early, small study (36 people) testing temporary stress-like effects, not a treatment. Results may not lead to real-world therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE DISORDER

Contacts and locations

Locations

The BRAINS Lab at Florida State University
RECRUITING

Tallahassee, Florida, 32306-4301, United States

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