COGNITIVE DYSFUNCTION

This study tests whether stem cells taken from a person's own fat can reduce brain inflammation and slow memory decline in adults aged 60-80 with early Alzheimer's or mild cognitive impairment. Participants receive four stem cell infusions over 12 weeks and are monitored for a ye…

This study tests whether taking a daily probiotic supplement (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes. Seventy participants will be randomly assigned to receive either the probiotic or a plac…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their op…

This study tests whether a daily supplement of alpha-linolenic acid (ALA), a plant-based omega-3 found in flaxseed and walnuts, can prevent memory decline in older adults with mild cognitive impairment who carry the APOE4 gene (a strong risk factor for Alzheimer's). About 20 part…

This study tests whether a program focused on healthy eating, exercise, and brain games can help prevent memory and thinking problems in older adults. Researchers will enroll 120 people aged 55 to 85 who are at higher risk for dementia. Participants will attend group sessions on …

This study compares two types of brain training programs for 30 adults with long COVID who have mild to moderate brain fog. One program uses computer games and real-life tasks to improve thinking speed and work skills, while the other focuses on relaxation and healthy habits. Bot…

This study tests whether a telerehabilitation program using a virtual reality (VR) app can improve thinking skills and social abilities in people with mild memory problems. About 480 adults aged 40-80 with subjective cognitive decline or mild cognitive impairment will use VR exer…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study tests whether a supervised online brain-training program can reduce memory and thinking problems (often called 'chemo brain') in breast cancer patients after chemotherapy. About 300 patients will either get the program with a neuropsychologist coach or do the same exer…

This study tests two remote rehabilitation programs for Veterans with traumatic brain injury (TBI) who struggle with attention, memory, and staying on track. Both programs are delivered via video and digital apps so Veterans can participate from home. The goal is to see which app…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet weekly with a coach online to learn problem-solving and relaxation skills. The goal is to see if the program improves quality of li…

This study tests whether a daily supplement of broccoli sprout extract can improve memory and thinking in adults aged 55-85 with mild cognitive impairment. Over 12 weeks, 100 participants will take either the extract or a placebo to see if it helps slow or reverse memory decline.…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study explores whether using a gentle ear nerve stimulation device at home, along with computer-based brain exercises, can help improve thinking skills and mood in adults aged 45-80 who have noticed changes in their memory or focus. Participants will do 10 sessions at home a…

This study tests whether stimulating a nerve in the wrist can safely help improve thinking and memory in people who recently had a traumatic brain injury. Thirty adults aged 18-64 with moderate injuries will receive either real or sham stimulation. The goal is to see if this simp…

This study compares two activities—playing video games and tossing balls—to see which better improves eye-hand coordination in older adults (60+) with mild cognitive impairment (MCI). Poor coordination can make daily tasks like dressing or eating harder. The study will measure co…

This study tests whether a neuroscience-based computer brain training program can improve memory and thinking in older adults (60+) who have had cognitive problems for at least 12 weeks after a confirmed COVID-19 infection. Researchers will compare the brain training to other com…

This study tests whether combining a gentle, non-invasive brain stimulation technique (called iTBS) with computer-based thinking exercises can help people with mild cognitive impairment (MCI). About 50 adults aged 60-85 will receive the same brain stimulation but be randomly assi…

This study looks at why some people who have had a stem cell transplant continue to feel extremely tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand t…

This study tests whether a 14-day mobile daily diary is a practical way to measure daily stress and thinking (cognitive) performance in breast cancer survivors from different racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past t…

This study looks at whether cognitive remediation—a type of brain training with coaching—can improve thinking skills, daily function, and behavior in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take …

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study tests a virtual reality (VR) tool called bWell to see if it can help assess and improve thinking skills in people with major depression. About 40 adults aged 19-55 with mild depression and self-reported memory or focus issues will try the VR assessments and either cogn…

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study is building a large group of 1,000 older adults (age 60+) in Tennessee to help researchers better understand Alzheimer's disease. Participants include people with normal memory, mild memory problems, or Alzheimer's. They will have yearly check-ups, brain scans, and blo…

This study looks at how chemotherapy given before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will track changes in an electronic frailty score and check for thinking problems. The goal is to see if chemo helps patients becom…

This study looks at how natural plant compounds (flavonoids) from foods like berries and tea are broken down by gut bacteria into substances that may protect the brain. Researchers will measure these substances in the blood and stool of 100 adults aged 50 and older who have a fam…

This study tests whether a special program can reduce confusion (delirium) after surgery in older adults. Researchers will screen patients aged 60 and older before their operation to find those at highest risk. Those identified will receive extra care recommendations and educatio…

This study looks at how often sexual problems occur in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. About 140 women with relapsing-remitting MS will fill out questionnaires and take simple tests. T…

This study looks at how fibromyalgia-related pain sensitivity (called central sensitization) is linked to problems with thinking, memory, and focus, often called 'brain fog.' Researchers will test 100 adults with fibromyalgia using questionnaires and cognitive tests to understand…

This study tests whether a new wearable device that uses ultrasound and light can safely and easily monitor blood flow in the brains of people who have had a stroke. Researchers will also include healthy older adults and people with dementia, depression, or delirium to compare re…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Falls are common in this group and can speed up memory loss. The goal is to develop better, personalized fall prevention strategies. Participants wi…

This study follows 1000 adults with primary aldosteronism (a hormone condition that raises blood pressure) for up to 5 years to see how often thinking and memory problems develop. Participants take regular cognitive tests and medical check-ups. The goal is to understand how commo…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…