COGNITIVE DYSFUNCTION

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This study tests whether stem cells taken from a person's own fat can reduce brain inflammation and slow memory decline in adults aged 60–80 with early Alzheimer's. Participants receive four stem cell infusions over 12 weeks and are monitored for a year. The goal is to see if thi…

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study tests whether a daily dose of flaxseed oil (alpha-linolenic acid) can slow memory loss and protect brain blood vessels in older adults with mild cognitive impairment and the APOE4 gene, which raises Alzheimer's risk. Twenty participants will take either the oil or a pl…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study tests whether a program of group nutrition classes, physical activities like walking and gardening, and at-home cognitive training can help prevent cognitive decline in older adults at higher risk for dementia. Researchers will enroll 120 people aged 55-85 and track ch…

After surgery, many older adults experience confusion or memory problems, known as delirium. This study tests a program that identifies patients at high risk before surgery and then uses simple steps—like better sleep and hydration—to prevent delirium. The program also educates f…

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests whether combining a special walking exercise with mild electrical brain stimulation can improve thinking and walking in adults aged 65 and older who have memory or mobility problems. Participants will do walking tasks while receiving either real or fake brain sti…

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study is testing a virtual reality (VR) program called bWell to see if it is a practical and enjoyable way to help people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will either use the bWell cognitive training or experience VR sc…

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study tests whether using a gentle nerve-stimulating device on the ear, combined with computer-based brain training, can improve thinking skills and mood in adults aged 45 to 80 who have noticed changes in their memory or attention. Participants will do 10 sessions at home a…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults who have had cognitive problems for at least 12 weeks after a COVID-19 infection. Researchers will compare the brain-training program to other computer activities in 75 …

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests whether taking broccoli sprout extract daily for 12 weeks can improve memory and thinking in adults aged 55-85 with mild cognitive impairment. One hundred participants will receive either the extract or a placebo. Researchers will measure changes in cognitive tes…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests two remote brain-training programs for Veterans who have had a traumatic brain injury (TBI) and struggle with focus, memory, or staying on track. About 120 Veterans will use either BrainStrong-GSR or BrainStrong-OPT via tele-rehabilitation and digital apps. The g…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation skills. The goal is to improve quality of life…

This study compares two fun activities—video games and ball tossing—to see if they can improve eye-hand coordination in older adults (60+) with mild cognitive impairment. Over 6 weeks, 34 participants will practice either a tapping game or ball exercises. Researchers will measure…

This study tests whether online cognitive exercises, guided by a neuropsychologist, can reduce memory and thinking problems (chemo brain) in 300 breast cancer patients after chemotherapy. Participants will do 20-minute brain games three times a week for 12 weeks, with some gettin…

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Participants will be monitored through diaries and monthly calls. The goal is to develop better fall prevention strategies for this vulnerable group…

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…

This study follows 1,000 adults with primary aldosteronism—a condition where the adrenal glands make too much aldosterone—to see how it affects thinking and memory over up to 5 years. Participants will take regular cognitive tests and have medical check-ups. The goal is to learn …

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study explores whether a new system using ultrasound and light sensors can remotely monitor brain blood flow in people who have had a stroke. Researchers will test the technology in 140 participants, including healthy older adults and those with stroke, dementia, depression,…

This study looks at how natural compounds in fruits and vegetables (called flavonoids) are broken down by gut bacteria and whether those breakdown products help protect the brain. Researchers will give 100 adults aged 50+ at risk for Alzheimer's a special diet and measure changes…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study looks at how central sensitization—a heightened pain response common in fibromyalgia—might be linked to cognitive problems like memory and concentration issues. Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is t…