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Can flaxseed oil protect the aging brain? new trial targets APOE4 carriers

NCT ID NCT07392723

Recruiting now Disease control Sponsor: Michal Schnaider Beeri, Ph.D. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a daily dose of flaxseed oil (alpha-linolenic acid) can slow memory loss and protect brain blood vessels in older adults with mild cognitive impairment and the APOE4 gene, which raises Alzheimer's risk. Twenty participants will take either the oil or a placebo for six months. Researchers will measure changes in thinking skills and brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Alpha-linolenic acid (ALA), also known as flaxseed oil
What this could lead to
If it works, this could point toward a simple, safe dietary supplement to slow memory loss in people at high genetic risk for Alzheimer's.
What could go wrong
This is a very small, early pilot trial with only 20 people. The supplement may not improve cognition or brain health, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

Apolipoprotein E, Deficiency or Defect of cognitive disorder Cognitive Dysfunction hyperlipoproteinemia type 3 Nerve Degeneration Alzheimer disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE APOLIPOPROTEIN E, DEFICIENCY OR DEFECT OF BLOOD-BRAIN BARRIER BRAIN AGING COGNITIVE DYSFUNCTION FATTY ACIDS, OMEGA-3

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Rutgers - Institute for Health

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

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